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OtherClinical Investigations (Human)

Radiation dosimetry and biodistribution of 68Ga-FAPI-46 PET imaging in cancer patients

Catherine Meyer, Magnus Dahlbom, Thomas Lindner, Sébastien Vauclin, Christine Mona, Roger Slavik, Johannes Czernin, Uwe Haberkorn and Jérémie Calais
Journal of Nuclear Medicine December 2019, jnumed.119.236786; DOI: https://doi.org/10.2967/jnumed.119.236786
Catherine Meyer
1 UCLA, United States;
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Magnus Dahlbom
1 UCLA, United States;
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Thomas Lindner
2 University Hospital Heidelberg, Germany;
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Sébastien Vauclin
3 DOSIsoft, France;
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Christine Mona
1 UCLA, United States;
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Roger Slavik
1 UCLA, United States;
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Johannes Czernin
4 UCLA School of Medicine
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Uwe Haberkorn
2 University Hospital Heidelberg, Germany;
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Jérémie Calais
1 UCLA, United States;
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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Radiation dosimetry and biodistribution of 68Ga-FAPI-46 PET imaging in cancer patients
Catherine Meyer, Magnus Dahlbom, Thomas Lindner, Sébastien Vauclin, Christine Mona, Roger Slavik, Johannes Czernin, Uwe Haberkorn, Jérémie Calais
Journal of Nuclear Medicine Dec 2019, jnumed.119.236786; DOI: 10.2967/jnumed.119.236786

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Radiation dosimetry and biodistribution of 68Ga-FAPI-46 PET imaging in cancer patients
Catherine Meyer, Magnus Dahlbom, Thomas Lindner, Sébastien Vauclin, Christine Mona, Roger Slavik, Johannes Czernin, Uwe Haberkorn, Jérémie Calais
Journal of Nuclear Medicine Dec 2019, jnumed.119.236786; DOI: 10.2967/jnumed.119.236786
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Cited By...

  • Evaluation of Fibroblast Activation Protein Expression Using 68Ga-FAPI46 PET in Hypertension-Induced Tissue Changes
  • Acquisition Duration Optimization Using Visual Grading Regression in [68Ga]FAPI-46 PET Imaging of Oncologic Patients
  • Prognostic Implications of 68Ga-FAPI-46 PET/CT-Derived Parameters on Overall Survival in Various Types of Solid Tumors
  • 68Ga-FAP-2286 PET of Solid Tumors: Biodistribution, Dosimetry, and Comparison with 18F-FDG
  • Characterizing Normal Variant [68Ga]Ga-FAPI-46 Uptake in the Epididymis
  • Incidental Focal 68Ga-FAPI-46 Uptake in a Urachal Remnant: A Potential Pitfall Mimicking a Malignant Peritoneal Lesion
  • Could FAP-Targeted Molecular Imaging Replace 18F-FDG for Standard-of-Care Oncologic PET?
  • Three-Time-Point PET Analysis of 68Ga-FAPI-46 in a Variety of Cancers
  • PET Imaging of Fibroblast Activation Protein in Various Types of Cancer Using 68Ga-FAP-2286: Comparison with 18F-FDG and 68Ga-FAPI-46 in a Single-Center, Prospective Study
  • A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake
  • Dual-Tracer PET/CT Protocol with [18F]-FDG and [68Ga]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept
  • Synthesis, Preclinical Evaluation, and a Pilot Clinical PET Imaging Study of 68Ga-Labeled FAPI Dimer
  • Initial Clinical Experience with 90Y-FAPI-46 Radioligand Therapy for Advanced-Stage Solid Tumors: A Case Series of 9 Patients
  • An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications
  • FAPI PET/CT: Will It End the Hegemony of 18F-FDG in Oncology?
  • The Latest Developments in Imaging of Fibroblast Activation Protein
  • Fibroblast Activation Protein-Targeted PET/CT with 68Ga-FAPI for Imaging IgG4-Related Disease: Comparison to 18F-FDG PET/CT
  • FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients
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More in this TOC Section

Clinical Investigations (Human)

  • The added value of 18F-FDG PET/CT compared to 68Ga-PSMA PET/CT in patients with castration-resistant prostate cancer
Show more Clinical Investigations (Human)

Clinical (Radiobiology/Dosimetry/Safety)

  • Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns
  • Dosimetry for Radiopharmaceutical Therapy: Current Practices and Commercial Resources
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Keywords

  • PET/CT
  • radiobiology/dosimetry
  • radiotracer tissue kinetics
  • biodistribution
  • dosimetry
  • FAPI
  • gallium-68
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