Fibroblast-Activation Protein PET and Histopathology in a Single-Center Database of 324 Patients and 21 Tumor Entities

Mean SUV_max on ⁶⁸Ga-FAPI PET for primary lesions (n = 221) (A) and hottest metastatic lesions per patient (n = 199) (B). Data points represent hottest lesions for individual patients. Data in A and B were sorted by mean SUV_max in A. Numbers of patients included for every tumor entity are given on x-axis. Red lines represent mean values. y-axis is split to account for extreme values. Primary and metastatic lesions for every tumor entity are provided in Supplemental Table 1.

Comparison of mean SUV_max for primary lesions (A) and metastatic lesions (B) between ⁶⁸Ga-FAPI and ¹⁸F-FDG PET across tumor entities. Entities are arranged as presented in Figure 1. Mean and SD are presented for every bar. Two-tailed paired t test was performed. *P < 0.05. **P < 0.01. ***P < 0.001.

Comparison of mean TBR_max for primary lesions between ⁶⁸Ga-FAPI and ¹⁸F-FDG PET across tumor entities, with different reference backgrounds (blood [A], liver [B], and muscle [C]). Entities are arranged as presented in Figure 1. Mean and SD are presented for every bar. Two-tailed paired t test was performed. *P < 0.05. **P < 0.01. ***P < 0.001.

Comparison of mean TBR_max for metastatic lesions between ⁶⁸Ga-FAPI and ¹⁸F-FDG PET across tumor entities, with different reference backgrounds (blood [A], liver [B], and muscle [C]). Entities are arranged as presented in Figure 1. Mean and SD are presented for every bar. Two-tailed paired t test was performed. *P < 0.05. **P < 0.01. ***P < 0.001.