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Research ArticleFEATURED ARTICLE OF THE MONTH

Fibroblast-Activation Protein PET and Histopathology in a Single-Center Database of 324 Patients and 21 Tumor Entities

Nader Hirmas, Rainer Hamacher, Miriam Sraieb, Marc Ingenwerth, Lukas Kessler, Kim M. Pabst, Francesco Barbato, Katharina Lueckerath, Stefan Kasper, Michael Nader, Hans-Ulrich Schildhaus, Claudia Kesch, Bastian von Tresckow, Christine Hanoun, Hubertus Hautzel, Clemens Aigner, Martin Glas, Martin Stuschke, Sherko Kümmel, Philipp Harter, Celine Lugnier, Waldemar Uhl, Marco Niedergethmann, Boris Hadaschik, Viktor Grünwald, Jens T. Siveke, Ken Herrmann and Wolfgang P. Fendler
Journal of Nuclear Medicine May 2023, 64 (5) 711-716; DOI: https://doi.org/10.2967/jnumed.122.264689
Nader Hirmas
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Rainer Hamacher
2Department of Medical Oncology, West German Cancer Center, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Miriam Sraieb
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Marc Ingenwerth
3Institute of Pathology, University Hospital Essen, Essen, Germany;
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Lukas Kessler
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Kim M. Pabst
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Francesco Barbato
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Katharina Lueckerath
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Stefan Kasper
2Department of Medical Oncology, West German Cancer Center, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Michael Nader
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Hans-Ulrich Schildhaus
3Institute of Pathology, University Hospital Essen, Essen, Germany;
4Targos Molecular Pathology Inc., Kassel, Germany;
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Claudia Kesch
5Department of Urology, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Bastian von Tresckow
6Department of Hematology and Stem Cell Transplantation, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Christine Hanoun
6Department of Hematology and Stem Cell Transplantation, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Hubertus Hautzel
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Clemens Aigner
7Department of Thoracic Surgery and Thoracic Endoscopy, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Martin Glas
8Division of Clinical Neurooncology, Department of Neurology, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Martin Stuschke
9Department of Radiation Therapy, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Sherko Kümmel
10Breast Unit, Kliniken Essen–Mitte, Essen, Germany, and Department of Gynecology with Breast Center, Charité–Universitätsmedizin Berlin, Berlin, Germany;
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Philipp Harter
11Department of Gynecology and Gynecologic Oncology, Evang. Kliniken Essen–Mitte, Essen, Germany;
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Celine Lugnier
12Department of Hematology and Oncology with Palliative Care, Ruhr University Bochum, Bochum, Germany;
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Waldemar Uhl
13Department of General and Visceral Surgery, Ruhr University Bochum, Bochum, Germany;
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Marco Niedergethmann
14Clinic for General and Visceral Surgery, Alfried Krupp Hospital, Essen, Germany;
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Boris Hadaschik
5Department of Urology, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Viktor Grünwald
5Department of Urology, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
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Jens T. Siveke
15Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany; and
16Division of Solid Tumor Translational Oncology, DKTK (Partner Site Essen) and German Cancer Research Center, Heidelberg, Germany
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Ken Herrmann
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Wolfgang P. Fendler
1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
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Article Information

vol. 64 no. 5 711-716
DOI 
https://doi.org/10.2967/jnumed.122.264689
PubMed 
36581374

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication July 18, 2022
  • Revision received November 8, 2022
  • Published online April 28, 2023.

Article Versions

  • previous version (December 29, 2022 - 08:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Nader Hirmas1,
  2. Rainer Hamacher2,
  3. Miriam Sraieb1,
  4. Marc Ingenwerth3,
  5. Lukas Kessler1,
  6. Kim M. Pabst1,
  7. Francesco Barbato1,
  8. Katharina Lueckerath1,
  9. Stefan Kasper2,
  10. Michael Nader1,
  11. Hans-Ulrich Schildhaus3,4,
  12. Claudia Kesch5,
  13. Bastian von Tresckow6,
  14. Christine Hanoun6,
  15. Hubertus Hautzel1,
  16. Clemens Aigner7,
  17. Martin Glas8,
  18. Martin Stuschke9,
  19. Sherko Kümmel10,
  20. Philipp Harter11,
  21. Celine Lugnier12,
  22. Waldemar Uhl13,
  23. Marco Niedergethmann14,
  24. Boris Hadaschik5,
  25. Viktor Grünwald5,
  26. Jens T. Siveke15,16,
  27. Ken Herrmann1 and
  28. Wolfgang P. Fendler1
  1. 1Department of Nuclear Medicine, University of Duisburg–Essen, and German Cancer Consortium (DKTK)–University Hospital Essen, Essen, Germany;
  2. 2Department of Medical Oncology, West German Cancer Center, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
  3. 3Institute of Pathology, University Hospital Essen, Essen, Germany;
  4. 4Targos Molecular Pathology Inc., Kassel, Germany;
  5. 5Department of Urology, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
  6. 6Department of Hematology and Stem Cell Transplantation, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
  7. 7Department of Thoracic Surgery and Thoracic Endoscopy, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
  8. 8Division of Clinical Neurooncology, Department of Neurology, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
  9. 9Department of Radiation Therapy, University of Duisburg–Essen, and DKTK–University Hospital Essen, Essen, Germany;
  10. 10Breast Unit, Kliniken Essen–Mitte, Essen, Germany, and Department of Gynecology with Breast Center, Charité–Universitätsmedizin Berlin, Berlin, Germany;
  11. 11Department of Gynecology and Gynecologic Oncology, Evang. Kliniken Essen–Mitte, Essen, Germany;
  12. 12Department of Hematology and Oncology with Palliative Care, Ruhr University Bochum, Bochum, Germany;
  13. 13Department of General and Visceral Surgery, Ruhr University Bochum, Bochum, Germany;
  14. 14Clinic for General and Visceral Surgery, Alfried Krupp Hospital, Essen, Germany;
  15. 15Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany; and
  16. 16Division of Solid Tumor Translational Oncology, DKTK (Partner Site Essen) and German Cancer Research Center, Heidelberg, Germany
  1. For correspondence or reprints, contact Wolfgang P. Fendler (wolfgang.fendler{at}uk-essen.de).
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Journal of Nuclear Medicine: 64 (5)
Journal of Nuclear Medicine
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May 1, 2023
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Fibroblast-Activation Protein PET and Histopathology in a Single-Center Database of 324 Patients and 21 Tumor Entities
Nader Hirmas, Rainer Hamacher, Miriam Sraieb, Marc Ingenwerth, Lukas Kessler, Kim M. Pabst, Francesco Barbato, Katharina Lueckerath, Stefan Kasper, Michael Nader, Hans-Ulrich Schildhaus, Claudia Kesch, Bastian von Tresckow, Christine Hanoun, Hubertus Hautzel, Clemens Aigner, Martin Glas, Martin Stuschke, Sherko Kümmel, Philipp Harter, Celine Lugnier, Waldemar Uhl, Marco Niedergethmann, Boris Hadaschik, Viktor Grünwald, Jens T. Siveke, Ken Herrmann, Wolfgang P. Fendler
Journal of Nuclear Medicine May 2023, 64 (5) 711-716; DOI: 10.2967/jnumed.122.264689

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Fibroblast-Activation Protein PET and Histopathology in a Single-Center Database of 324 Patients and 21 Tumor Entities
Nader Hirmas, Rainer Hamacher, Miriam Sraieb, Marc Ingenwerth, Lukas Kessler, Kim M. Pabst, Francesco Barbato, Katharina Lueckerath, Stefan Kasper, Michael Nader, Hans-Ulrich Schildhaus, Claudia Kesch, Bastian von Tresckow, Christine Hanoun, Hubertus Hautzel, Clemens Aigner, Martin Glas, Martin Stuschke, Sherko Kümmel, Philipp Harter, Celine Lugnier, Waldemar Uhl, Marco Niedergethmann, Boris Hadaschik, Viktor Grünwald, Jens T. Siveke, Ken Herrmann, Wolfgang P. Fendler
Journal of Nuclear Medicine May 2023, 64 (5) 711-716; DOI: 10.2967/jnumed.122.264689
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Cited By...

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  • Design, Preclinical Evaluation, and Clinical Translation of 68Ga-FAPI-LM3, a Heterobivalent Molecule for PET Imaging of Nasopharyngeal Carcinoma
  • Diagnostic Accuracy of 68Ga-FAPI Versus 18F-FDG PET in Patients with Various Malignancies
  • Fibroblast Activation Protein {alpha}-Directed Imaging and Therapy of Solitary Fibrous Tumor
  • Molecular Imaging Biomarkers in Cardiooncology: A View on Established Technologies and Future Perspectives
  • Comparison of Baseline 68Ga-FAPI and 18F-FDG PET/CT for Prediction of Response and Clinical Outcome in Patients with Unresectable Hepatocellular Carcinoma Treated with PD-1 Inhibitor and Lenvatinib
  • Tumor Characterization by [68Ga]FAPI-46 PET/CT Can Improve Treatment Selection for Pancreatic Cancer Patients: An Interim Analysis of a Prospective Clinical Trial
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Keywords

  • FAPI
  • PET
  • oncology
  • staging
  • theranostic
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