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Journal of Nuclear Medicine

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Table of Contents

May 1, 2023; Volume 64,Issue 5

This Month in JNM

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    This Month in JNM
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 8A;

Editor's Page

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    What Is Theranostics?
    Wolfgang A. Weber, Henryk Barthel, Frank Bengel, Matthias Eiber, Ken Herrmann and Michael Schäfers
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 669-670; DOI: https://doi.org/10.2967/jnumed.123.265670

Highlights

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    2022 SNMMI Highlights Lecture: General Nuclear Medicine
    Andrei Iagaru
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 671-677; DOI: https://doi.org/10.2967/jnumed.123.265758

Discussions with Leaders

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    Looking at the Future of Prostate Cancer Treatment
    Michael J. Morris, Jeremie Calais and Johannes Czernin
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 678-681; DOI: https://doi.org/10.2967/jnumed.123.265684

Hot Topics

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    The Emergence of Somatostatin Antagonist–Based Theranostics: Paving the Road Toward Another Success?
    Alessio Imperiale, Abhishek Jha, Leah Meuter, Guillaume P. Nicolas, David Taïeb and Karel Pacak
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 682-684; DOI: https://doi.org/10.2967/jnumed.123.265406

State of the Art

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    Clinical Translation of Targeted α-Therapy: An Evolution or a Revolution?
    Benedikt Feuerecker, Clemens Kratochwil, Hojjat Ahmadzadehfar, Alfred Morgenstern, Matthias Eiber, Ken Herrmann and Kelsey L. Pomykala
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 685-692; DOI: https://doi.org/10.2967/jnumed.122.265353

Continuing Education

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    Amino Acid PET in Neurooncology
    Norbert Galldiks, Philipp Lohmann, Gereon R. Fink and Karl-Josef Langen
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 693-700; DOI: https://doi.org/10.2967/jnumed.122.264859

Editorial

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    An Opinion on ChatGPT in Health Care—Written by Humans Only
    Jens Kleesiek, Yonghui Wu, Gregor Stiglic, Jan Egger and Jiang Bian
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 701-703; DOI: https://doi.org/10.2967/jnumed.123.265687

Oncology

  • Clinical

    • <sup>64</sup>Cu Treatment Planning and <sup>67</sup>Cu Therapy with Radiolabeled [<sup>64</sup>Cu/<sup>67</sup>Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry
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      64Cu Treatment Planning and 67Cu Therapy with Radiolabeled [64Cu/67Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry
      Dale L. Bailey, Kathy P. Willowson, Matthew Harris, Colin Biggin, Alireza Aslani, Nigel A. Lengkeek, Jon Stoner, M. Enid Eslick, Harry Marquis, Michelle Parker, Paul J. Roach and Geoffrey P. Schembri
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 704-710; DOI: https://doi.org/10.2967/jnumed.122.264586

Theranostics

  • Clinical

    • FEATURED ARTICLE OF THE MONTH

      • Fibroblast-Activation Protein PET and Histopathology in a Single-Center Database of 324 Patients and 21 Tumor Entities
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        Fibroblast-Activation Protein PET and Histopathology in a Single-Center Database of 324 Patients and 21 Tumor Entities
        Nader Hirmas, Rainer Hamacher, Miriam Sraieb, Marc Ingenwerth, Lukas Kessler, Kim M. Pabst, Francesco Barbato, Katharina Lueckerath, Stefan Kasper, Michael Nader, Hans-Ulrich Schildhaus, Claudia Kesch, Bastian von Tresckow, Christine Hanoun, Hubertus Hautzel, Clemens Aigner, Martin Glas, Martin Stuschke, Sherko Kümmel, Philipp Harter, Celine Lugnier, Waldemar Uhl, Marco Niedergethmann, Boris Hadaschik, Viktor Grünwald, Jens T. Siveke, Ken Herrmann and Wolfgang P. Fendler
        Journal of Nuclear Medicine May 1, 2023, 64 (5) 711-716; DOI: https://doi.org/10.2967/jnumed.122.264689
    • Initial Results of <sup>68</sup>Ga-FAPI-46 PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer
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      Initial Results of 68Ga-FAPI-46 PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer
      Philipp Backhaus, Matthias C. Burg, Inga Asmus, Michaela Pixberg, Florian Büther, Hans-Jörg Breyholz, Randy Yeh, Stefanie B. Weigel, Patricia Stichling, Walter Heindel, Stefanie Bobe, Peter Barth, Joke Tio and Michael Schäfers
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 717-723; DOI: https://doi.org/10.2967/jnumed.122.264871
    • Noninvasive Assessment of Human Epidermal Growth Factor Receptor 2 (HER2) in Esophagogastric Cancer Using <sup>89</sup>Zr-Trastuzumab PET: A Pilot Study
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      Noninvasive Assessment of Human Epidermal Growth Factor Receptor 2 (HER2) in Esophagogastric Cancer Using 89Zr-Trastuzumab PET: A Pilot Study
      Melissa A. Lumish, Steven B. Maron, Viktoriya Paroder, Joanne F. Chou, Marinela Capanu, Steven Philemond, Joseph A. O’Donoghue, Heiko Schöder, Jason S. Lewis, Serge K. Lyashchenko, Neeta Pandit-Taskar and Yelena Y. Janjigian
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 724-730; DOI: https://doi.org/10.2967/jnumed.122.264470
    • Is <sup>18</sup>F-FDG PET Needed to Assess <sup>177</sup>Lu-PSMA Therapy Eligibility? A VISION-like, Single-Center Analysis
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      Is 18F-FDG PET Needed to Assess 177Lu-PSMA Therapy Eligibility? A VISION-like, Single-Center Analysis
      Robert Seifert, Tugce Telli, Boris Hadaschik, Wolfgang P. Fendler, Phillip H. Kuo and Ken Herrmann
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 731-737; DOI: https://doi.org/10.2967/jnumed.122.264741
    • Unspecific <sup>18</sup>F-PSMA-1007 Bone Uptake Evaluated Through PSMA-11 PET, Bone Scanning, and MRI Triple Validation in Patients with Biochemical Recurrence of Prostate Cancer
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      Unspecific 18F-PSMA-1007 Bone Uptake Evaluated Through PSMA-11 PET, Bone Scanning, and MRI Triple Validation in Patients with Biochemical Recurrence of Prostate Cancer
      Robert Seifert, Tugce Telli, Marcel Opitz, Francesco Barbato, Christoph Berliner, Michael Nader, Lale Umutlu, Martin Stuschke, Boris Hadaschik, Ken Herrmann and Wolfgang P. Fendler
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 738-743; DOI: https://doi.org/10.2967/jnumed.118.215434
    • A Pilot Study of <sup>68</sup>Ga-PSMA11 and <sup>68</sup>Ga-RM2 PET/MRI for Biopsy Guidance in Patients with Suspected Prostate Cancer
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      A Pilot Study of 68Ga-PSMA11 and 68Ga-RM2 PET/MRI for Biopsy Guidance in Patients with Suspected Prostate Cancer
      Heying Duan, Pejman Ghanouni, Bruce Daniel, Jarrett Rosenberg, Alan Thong, Christian Kunder, Carina Mari Aparici, Guido A. Davidzon, Farshad Moradi, Geoffrey A. Sonn and Andrei Iagaru
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 744-750; DOI: https://doi.org/10.2967/jnumed.122.264448
  • Basic

    • Targeted α-Therapy Using <sup>225</sup>Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment
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      Targeted α-Therapy Using 225Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment
      Thomas Ertveldt, Ahmet Krasniqi, Hannelore Ceuppens, Janik Puttemans, Yana Dekempeneer, Kevin De Jonghe, Wout de Mey, Quentin Lecocq, Yannick De Vlaeminck, Robin Maximilian Awad, Cleo Goyvaerts, Kim De Veirman, Alfred Morgenstern, Frank Bruchertseifer, Marleen Keyaerts, Nick Devoogdt, Matthias D’Huyvetter and Karine Breckpot
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 751-758; DOI: https://doi.org/10.2967/jnumed.122.264752
    • FEATURED BASIC SCIENCE ARTICLE

      • Fibroblast Activation Protein–Targeted Radioligand Therapy for Treatment of Solid Tumors
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        Fibroblast Activation Protein–Targeted Radioligand Therapy for Treatment of Solid Tumors
        Spencer D. Lindeman, Ramesh Mukkamala, Autumn Horner, Pooja Tudi, Owen C. Booth, Roxanne Huff, Joshua Hinsey, Anders Hovstadius, Peter Martone, Fenghua Zhang, Madduri Srinivasarao, Abigail Cox and Philip S. Low
        Journal of Nuclear Medicine May 1, 2023, 64 (5) 759-766; DOI: https://doi.org/10.2967/jnumed.122.264494

Radiobiology/Dosimetry

  • Clinical

    • Toward Single-Time-Point Image-Based Dosimetry of <sup>177</sup>Lu-PSMA-617 Therapy
      Open Access
      Toward Single-Time-Point Image-Based Dosimetry of 177Lu-PSMA-617 Therapy
      Julia Brosch-Lenz, Astrid Delker, Friederike Völter, Lena M. Unterrainer, Lena Kaiser, Peter Bartenstein, Sibylle Ziegler, Arman Rahmim, Carlos Uribe and Guido Böning
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 767-774; DOI: https://doi.org/10.2967/jnumed.122.264594
    • Biodistribution, Dosimetry, and Pharmacokinetics of <sup>68</sup>Ga-CBP8: A Type I Collagen–Targeted PET Probe
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      Biodistribution, Dosimetry, and Pharmacokinetics of 68Ga-CBP8: A Type I Collagen–Targeted PET Probe
      David Izquierdo-Garcia, Pauline Désogère, Mariane Le Fur, Sergey Shuvaev, Iris Y. Zhou, Ian Ramsay, Michael Lanuti, Onofrio A. Catalano, Ciprian Catana, Peter Caravan and Sydney B. Montesi
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 775-781; DOI: https://doi.org/10.2967/jnumed.122.264530
  • Basic

    • Dosimetric Variability Across a Library of Computational Tumor Phantoms
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      Dosimetric Variability Across a Library of Computational Tumor Phantoms
      Lukas M. Carter, Simone Krebs, Harry Marquis, Juan C. Ocampo Ramos, Edmond A. Olguin, Emilia O. Mason, Wesley E. Bolch, Pat B. Zanzonico and Adam L. Kesner
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 782-790; DOI: https://doi.org/10.2967/jnumed.122.264916

Cardiovascular

  • Clinical

    • Long-Term Prognostic Value of <sup>82</sup>Rb PET/CT–Determined Myocardial Perfusion and Flow Reserve in Cancer Patients
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      Long-Term Prognostic Value of 82Rb PET/CT–Determined Myocardial Perfusion and Flow Reserve in Cancer Patients
      Josef J. Fox, Audrey Mauguen, Kimiteru Ito, Dipti Gupta, Alice Yu, Thomas H. Schindler, H. William Strauss and Heiko Schöder
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 791-796; DOI: https://doi.org/10.2967/jnumed.122.264795

Pulmonary

  • Clinical

    • Molecular Imaging of Pulmonary Inflammation in Users of Electronic and Combustible Cigarettes: A Pilot Study
      Open Access
      Molecular Imaging of Pulmonary Inflammation in Users of Electronic and Combustible Cigarettes: A Pilot Study
      Reagan R. Wetherill, Robert K. Doot, Anthony J. Young, Hsiaoju Lee, Erin K. Schubert, Corinde E. Wiers, Frank T. Leone, Robert H. Mach, Henry R. Kranzler and Jacob G. Dubroff
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 797-802; DOI: https://doi.org/10.2967/jnumed.122.264529

Molecular Imaging

  • Clinical

    • Detection of Early Esophageal Neoplastic Barrett Lesions with Quantified Fluorescence Molecular Endoscopy Using Cetuximab-800CW
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      Detection of Early Esophageal Neoplastic Barrett Lesions with Quantified Fluorescence Molecular Endoscopy Using Cetuximab-800CW
      Ruben Y. Gabriëls, Lisanne E. van Heijst, Wouter T.R. Hooghiemstra, Anne M. van der Waaij, Gursah Kats-Ugurlu, Arend Karrenbeld, Dominic J. Robinson, Anna Tenditnaya, Vasilis Ntziachristos, Dimitris Gorpas and Wouter B. Nagengast
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 803-808; DOI: https://doi.org/10.2967/jnumed.122.264656
  • Translational

    • Imaging Diverse Pathogenic Bacteria In Vivo with <sup>18</sup>F-Fluoromannitol PET
      Open Access
      Imaging Diverse Pathogenic Bacteria In Vivo with 18F-Fluoromannitol PET
      Spenser R. Simpson, Alexandria E. Kesterson, Justin H. Wilde, Zoraiz Qureshi, Bijoy Kundu, Mark P. Simons and Kiel D. Neumann
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 809-815; DOI: https://doi.org/10.2967/jnumed.122.264854

Neurology

  • Clinical

    • Utility of Amino Acid PET in the Differential Diagnosis of Recurrent Brain Metastases and Treatment-Related Changes: A Meta-analysis
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      Utility of Amino Acid PET in the Differential Diagnosis of Recurrent Brain Metastases and Treatment-Related Changes: A Meta-analysis
      Timo Schlürmann, Birgit Waschulzik, Stephanie Combs, Jens Gempt, Benedikt Wiestler, Wolfgang Weber and Igor Yakushev
      Journal of Nuclear Medicine May 1, 2023, 64 (5) 816-821; DOI: https://doi.org/10.2967/jnumed.122.264803

Invited Perspective

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    Tau PET Visual Reads: Research and Clinical Applications and Future Directions
    David N. Soleimani-Meigooni and Gil D. Rabinovici
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 822-824; DOI: https://doi.org/10.2967/jnumed.122.265017

Physics and Instrumentation

  • A Multicenter Study on Observed Discrepancies Between Vendor-Stated and PET-Measured <sup>90</sup>Y Activities for Both Glass and Resin Microsphere Devices
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    A Multicenter Study on Observed Discrepancies Between Vendor-Stated and PET-Measured 90Y Activities for Both Glass and Resin Microsphere Devices
    Silvano Gnesin, Justin K. Mikell, Maurizio Conti, John O. Prior, Thomas Carlier, Thiago V.M. Lima and Yuni K. Dewaraja
    Journal of Nuclear Medicine May 1, 2023, 64 (5) 825-828; DOI: https://doi.org/10.2967/jnumed.122.264458
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In this issue

Journal of Nuclear Medicine: 64 (5)
Journal of Nuclear Medicine
Vol. 64, Issue 5
May 1, 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)

Issue highlights

  • Fibroblast-Activation Protein PET and Histopathology in a Single-Center Database of 324 Patients and 21 Tumor Entities
  • Fibroblast Activation Protein–Targeted Radioligand Therapy for Treatment of Solid Tumors
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    • Clinical
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    • Clinical
      • FEATURED ARTICLE OF THE MONTH
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      • FEATURED BASIC SCIENCE ARTICLE
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  • Performance Evaluation of the uEXPLORER Total-Body PET/CT Scanner Based on NEMA NU 2-2018 with Additional Tests to Characterize PET Scanners with a Long Axial Field of View
  • Slow but Evident Recovery from Neocortical Dysfunction and Cognitive Impairment in a Series of Chronic COVID-19 Patients
  • Impact of 68Ga-FAPI PET/CT Imaging on the Therapeutic Management of Primary and Recurrent Pancreatic Ductal Adenocarcinomas
  • Tumor Response to Radiopharmaceutical Therapies: The Knowns and the Unknowns
  • Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review
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