First-in-Humans Evaluation of Safety and Dosimetry of 64Cu-LLP2A for PET Imaging

Richard Laforest; Anchal Ghai; Tyler J. Fraum; Reiko Oyama; Jennifer Frye; Helen Kaemmerer; Greg Gaehle; Tom Voller; Cedric Mpoy; Buck E. Rogers; Mark Fiala; Kooresh I. Shoghi; Samuel Achilefu; Michael Rettig; Ravi Vij; John F. DiPersio; Sally Schwarz; Monica Shokeen; Farrokh Dehdashti

doi:10.2967/jnumed.122.264349

Research ArticleBasic Science Investigation

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First-in-Humans Evaluation of Safety and Dosimetry of ⁶⁴Cu-LLP2A for PET Imaging

Richard Laforest, Anchal Ghai, Tyler J. Fraum, Reiko Oyama, Jennifer Frye, Helen Kaemmerer, Greg Gaehle, Tom Voller, Cedric Mpoy, Buck E. Rogers, Mark Fiala, Kooresh I. Shoghi, Samuel Achilefu, Michael Rettig, Ravi Vij, John F. DiPersio, Sally Schwarz, Monica Shokeen and Farrokh Dehdashti

Journal of Nuclear Medicine February 2023, 64 (2) 320-328; DOI: https://doi.org/10.2967/jnumed.122.264349

Richard Laforest

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Anchal Ghai

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Tyler J. Fraum

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Reiko Oyama

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Jennifer Frye

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Helen Kaemmerer

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Greg Gaehle

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Tom Voller

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Cedric Mpoy

3Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri;

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Buck E. Rogers

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

3Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri;

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Mark Fiala

4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and

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Kooresh I. Shoghi

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

5Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri

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Samuel Achilefu

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Michael Rettig

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and

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Ravi Vij

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and

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John F. DiPersio

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and

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Sally Schwarz

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Monica Shokeen

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

5Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri

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Farrokh Dehdashti

1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;

2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;

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Vol. 64, Issue 2

February 1, 2023

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First-in-Humans Evaluation of Safety and Dosimetry of ⁶⁴Cu-LLP2A for PET Imaging

Journal of Nuclear Medicine Feb 2023, 64 (2) 320-328; DOI: 10.2967/jnumed.122.264349

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First-in-Humans Evaluation of Safety and Dosimetry of ⁶⁴Cu-LLP2A for PET Imaging

Journal of Nuclear Medicine Feb 2023, 64 (2) 320-328; DOI: 10.2967/jnumed.122.264349

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Keywords

radiochemistry
radiopharmaceuticals
dosimetry
first-in-humans
safety
translational imaging

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