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Research ArticleBasic Science Investigation
Open Access

First-in-Humans Evaluation of Safety and Dosimetry of 64Cu-LLP2A for PET Imaging

Richard Laforest, Anchal Ghai, Tyler J. Fraum, Reiko Oyama, Jennifer Frye, Helen Kaemmerer, Greg Gaehle, Tom Voller, Cedric Mpoy, Buck E. Rogers, Mark Fiala, Kooresh I. Shoghi, Samuel Achilefu, Michael Rettig, Ravi Vij, John F. DiPersio, Sally Schwarz, Monica Shokeen and Farrokh Dehdashti
Journal of Nuclear Medicine February 2023, 64 (2) 320-328; DOI: https://doi.org/10.2967/jnumed.122.264349
Richard Laforest
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Anchal Ghai
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Tyler J. Fraum
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Reiko Oyama
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Jennifer Frye
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Helen Kaemmerer
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Greg Gaehle
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Tom Voller
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Cedric Mpoy
3Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri;
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Buck E. Rogers
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
3Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri;
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Mark Fiala
4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and
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Kooresh I. Shoghi
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
5Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri
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Samuel Achilefu
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Michael Rettig
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and
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Ravi Vij
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and
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John F. DiPersio
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and
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Sally Schwarz
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Monica Shokeen
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
5Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri
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Farrokh Dehdashti
1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Article Information

vol. 64 no. 2 320-328
DOI 
https://doi.org/10.2967/jnumed.122.264349
PubMed 
36008121

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication May 4, 2022
  • Revision received August 11, 2022
  • Published online February 1, 2023.

Article Versions

  • previous version (August 25, 2022 - 12:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Richard Laforest*,1,2,
  2. Anchal Ghai*,2,
  3. Tyler J. Fraum1,2,
  4. Reiko Oyama2,
  5. Jennifer Frye2,
  6. Helen Kaemmerer2,
  7. Greg Gaehle2,
  8. Tom Voller2,
  9. Cedric Mpoy3,
  10. Buck E. Rogers1,3,
  11. Mark Fiala4,
  12. Kooresh I. Shoghi1,2,5,
  13. Samuel Achilefu1,2,
  14. Michael Rettig1,4,
  15. Ravi Vij1,4,
  16. John F. DiPersio1,4,
  17. Sally Schwarz2,
  18. Monica Shokeen1,2,5 and
  19. Farrokh Dehdashti1,2
  1. 1Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri;
  2. 2Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri;
  3. 3Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri;
  4. 4Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; and
  5. 5Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri
  1. For correspondence or reprints, contact Farrokh Dehdashti (dehdashtif{at}wustl.edu) or Monica Shokeen (mshokeen{at}wustl.edu).
  1. ↵* Contributed equally to this work.

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First-in-Humans Evaluation of Safety and Dosimetry of 64Cu-LLP2A for PET Imaging
Richard Laforest, Anchal Ghai, Tyler J. Fraum, Reiko Oyama, Jennifer Frye, Helen Kaemmerer, Greg Gaehle, Tom Voller, Cedric Mpoy, Buck E. Rogers, Mark Fiala, Kooresh I. Shoghi, Samuel Achilefu, Michael Rettig, Ravi Vij, John F. DiPersio, Sally Schwarz, Monica Shokeen, Farrokh Dehdashti
Journal of Nuclear Medicine Feb 2023, 64 (2) 320-328; DOI: 10.2967/jnumed.122.264349

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First-in-Humans Evaluation of Safety and Dosimetry of 64Cu-LLP2A for PET Imaging
Richard Laforest, Anchal Ghai, Tyler J. Fraum, Reiko Oyama, Jennifer Frye, Helen Kaemmerer, Greg Gaehle, Tom Voller, Cedric Mpoy, Buck E. Rogers, Mark Fiala, Kooresh I. Shoghi, Samuel Achilefu, Michael Rettig, Ravi Vij, John F. DiPersio, Sally Schwarz, Monica Shokeen, Farrokh Dehdashti
Journal of Nuclear Medicine Feb 2023, 64 (2) 320-328; DOI: 10.2967/jnumed.122.264349
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Keywords

  • radiochemistry
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  • safety
  • translational imaging
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