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Research ArticleSPECIAL CONTRIBUTION

Joint EANM, SNMMI, and IAEA Enabling Guide: How to Set up a Theranostics Center

Ken Herrmann, Luca Giovanella, Andrea Santos, Jonathan Gear, Pinar Ozgen Kiratli, Jens Kurth, Ana M. Denis-Bacelar, Roland Hustinx, Marianne Patt, Richard L. Wahl, Diana Paez, Francesco Giammarile, Hossein Jadvar, Neeta Pandit-Taskar, Munir Ghesani and Jolanta Kunikowska
Journal of Nuclear Medicine December 2022, 63 (12) 1836-1843; DOI: https://doi.org/10.2967/jnumed.122.264321
Ken Herrmann
1Department of Nuclear Medicine, University of Duisburg-Essen, Duisburg, Germany;
2German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany;
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Luca Giovanella
3Clinic for Nuclear Medicine and Molecular Imaging, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland;
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Andrea Santos
4Department of Nuclear Medicine, Hospital Cuf Descobertas, Lisbon, Portugal;
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Jonathan Gear
5Joint Department of Physics, Royal Marsden NHS Foundation Trust, Sutton, Sutton, United Kingdom;
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Pinar Ozgen Kiratli
6Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey;
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Jens Kurth
7Department of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany;
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Ana M. Denis-Bacelar
8National Physical Laboratory, Teddington, United Kingdom;
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Roland Hustinx
9Division of Nuclear Medicine and Oncological Imaging, University Hospital of Liège, Liège, Belgium;
10GIGA-CRC in vivo imaging, University of Liège, Liège, Belgium;
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Marianne Patt
11Department for Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany;
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Richard L. Wahl
12Department of Radiology, Washington University School of Medicine, St. Louis, Missouri;
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Diana Paez
13Nuclear Medicine and Diagnostic Imaging Section, Division of Human Health, Department of Nuclear Sciences and Application, International Atomic Energy Agency, Vienna, Austria;
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Francesco Giammarile
13Nuclear Medicine and Diagnostic Imaging Section, Division of Human Health, Department of Nuclear Sciences and Application, International Atomic Energy Agency, Vienna, Austria;
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Hossein Jadvar
14Division of Nuclear Medicine, Department of Radiology, University of Southern California, Los Angeles, California;
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Neeta Pandit-Taskar
15Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
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Munir Ghesani
16Diagnostic, Molecular & Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, New York; and
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Jolanta Kunikowska
17Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland
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Abstract

The theranostics concept using the same target for both imaging and therapy dates back to the middle of the last century, when radioactive iodine was first used to treat thyroid diseases. Since then, radioiodine has become broadly established clinically for diagnostic imaging and therapy of benign and malignant thyroid disease, worldwide. However, only since the approval of SSTR2-targeting theranostics following the NETTER-1 trial in neuroendocrine tumors, and the positive outcome of the VISION trial has theranostics gained substantial attention beyond nuclear medicine. The roll-out of radioligand therapy for treating a high-incidence tumor such as prostate cancer requires the expansion of existing and the establishment of new theranostics centers. Despite wide global variation in the regulatory, financial and medical landscapes, this guide attempts to provide valuable information to enable interested stakeholders to safely initiate and operate theranostic centers. This enabling guide does not intend to answer all possible questions, but rather to serve as an overarching framework for multiple, more detailed future initiatives. It recognizes that there are regional differences in the specifics of regulation of radiation safety, but common elements of best practice valid globally.

  • theranostics
  • radionuclide theranostics
  • nuclear medicine
  • PSMA
  • PRRT

Footnotes

  • This article was originally published in Herrmann K, Giovanella L, Santos A, Gear J, et al. Joint EANM, SNMMI and IAEA enabling guide: how to set up a theranostics center. Eur J Nucl Med Mol Imaging. 2022 Apr 11. doi: 10.1007/s00259–022–05785-x under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as appropriate credit is provided to the original author(s) and source, a link is provided to the Creative Commons license, and indication of changes is provided. This version was submitted to The Journal of Nuclear Medicine by the authors and has been adapted for publication in JNM.

  • Published online Apr. 21, 2022.

  • © 2022 by the Society of Nuclear Medicine and Molecular Imaging.
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Journal of Nuclear Medicine: 63 (12)
Journal of Nuclear Medicine
Vol. 63, Issue 12
December 1, 2022
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Joint EANM, SNMMI, and IAEA Enabling Guide: How to Set up a Theranostics Center
Ken Herrmann, Luca Giovanella, Andrea Santos, Jonathan Gear, Pinar Ozgen Kiratli, Jens Kurth, Ana M. Denis-Bacelar, Roland Hustinx, Marianne Patt, Richard L. Wahl, Diana Paez, Francesco Giammarile, Hossein Jadvar, Neeta Pandit-Taskar, Munir Ghesani, Jolanta Kunikowska
Journal of Nuclear Medicine Dec 2022, 63 (12) 1836-1843; DOI: 10.2967/jnumed.122.264321

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Joint EANM, SNMMI, and IAEA Enabling Guide: How to Set up a Theranostics Center
Ken Herrmann, Luca Giovanella, Andrea Santos, Jonathan Gear, Pinar Ozgen Kiratli, Jens Kurth, Ana M. Denis-Bacelar, Roland Hustinx, Marianne Patt, Richard L. Wahl, Diana Paez, Francesco Giammarile, Hossein Jadvar, Neeta Pandit-Taskar, Munir Ghesani, Jolanta Kunikowska
Journal of Nuclear Medicine Dec 2022, 63 (12) 1836-1843; DOI: 10.2967/jnumed.122.264321
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  • Article
    • Abstract
    • REGULATORY, LOGISTICAL AND TECHNICAL CONSIDERATIONS
    • RADIONUCLIDES AND RADIOPHARMACEUTICALS USED
    • RADIATION PROTECTION, SHIELDING
    • STORAGE OF RADIOPHARMACEUTICALS
    • ADMINISTRATION OF RADIOPHARMACEUTICALS
    • RADIOACTIVE WASTE
    • RELEASE OF PATIENTS AFTER TREATMENT
    • HANDLING OF DECEASED PERSONS
    • TREATMENT PLANNING, OPTIMIZATION AND VERIFICATION
    • MEDICAL CONSIDERATIONS AND REFLECTIONS
    • INTEGRATED CARE
    • INTRA-PROFESSIONAL STAKEHOLDERS
    • TRAINING AND EDUCATION
    • LESSONS LEARNT
    • PROVIDING POINTS OF CONTACT
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Keywords

  • theranostics
  • radionuclide theranostics
  • nuclear medicine
  • PSMA
  • PRRT
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