Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Editorial Contact
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Editorial Contact
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Follow SNMMI on Twitter
  • Visit SNMMI on Facebook
Research ArticleNeurology

Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort

Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D’Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang and Richard E. Carson
Journal of Nuclear Medicine March 2021, 62 (3) 418-421; DOI: https://doi.org/10.2967/jnumed.120.243949
Mika Naganawa
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Dominique Gallezot
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sjoerd J. Finnema
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Matuskey
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
3Department of Neurology, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adam Mecca
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nabeel B. Nabulsi
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Labaree
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jim Ropchan
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert T. Malison
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Deepak Cyril D’Souza
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Irina Esterlis
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kamil Detyniecki
3Department of Neurology, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher H. van Dyck
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yiyun Huang
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richard E. Carson
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Visual Abstract

Figure1
  • Download figure
  • Open in new tab
  • Download powerpoint

Abstract

11C-UCB-J ((R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) is a PET tracer for synaptic vesicle glycoprotein 2A, which may be a marker of synaptic density. To simplify the scan protocol, SUV ratios (SUVRs) were compared with model-based nondisplaceable binding potential (BPND) to select the optimal time window in healthy and neuropsychiatric subjects. Methods: In total, 141 scans were acquired for 90 min. Arterial blood sampling and metabolite analysis were conducted. SUVR-1 (centrum semiovale reference region) was computed for six 30-min windows and compared with 1-tissue-compartment model BPND. Simulations were performed to assess the time dependency of SUVR-1. Results: Greater correlation and less bias were observed for SUVR-1 at later time windows for all subjects. Simulations showed that the agreement between SUVR-1 and BPND is time-dependent. Conclusion: The 60- to 90-min period provided the best match between SUVR-1 and BPND (−1% ± 7%); thus, a short scan is sufficient for accurate quantification of 11C-UCB-J–specific binding.

  • synaptic vesicle protein 2A
  • SV2A
  • PET
  • SUVR
  • brain imaging

Footnotes

  • Published online Jul. 9, 2020.

  • © 2021 by the Society of Nuclear Medicine and Molecular Imaging.
View Full Text

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

SNMMI members

SNMMI Member Login

Login to the site using your SNMMI member credentials

Individuals

Non-Member Login

Login as an individual user

PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 62 (3)
Journal of Nuclear Medicine
Vol. 62, Issue 3
March 1, 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort
Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D’Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang, Richard E. Carson
Journal of Nuclear Medicine Mar 2021, 62 (3) 418-421; DOI: 10.2967/jnumed.120.243949

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort
Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D’Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang, Richard E. Carson
Journal of Nuclear Medicine Mar 2021, 62 (3) 418-421; DOI: 10.2967/jnumed.120.243949
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Visual Abstract
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Neurology

  • First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
  • Dopaminergic Nigrostriatal Connectivity in Early Parkinson Disease: In Vivo Neuroimaging Study of 11C-DTBZ PET Combined with Correlational Tractography
  • First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A
Show more Neurology

Clinical

  • Dopaminergic Nigrostriatal Connectivity in Early Parkinson Disease: In Vivo Neuroimaging Study of 11C-DTBZ PET Combined with Correlational Tractography
  • High Interobserver Agreement for the Standardized Reporting System SSTR-RADS 1.0 on Somatostatin Receptor PET/CT
  • Somatostatin Receptor–Targeted Radiopeptide Therapy in Treatment-Refractory Meningioma: Individual Patient Data Meta-analysis
Show more Clinical

Similar Articles

Keywords

  • synaptic vesicle protein 2A
  • SV2A
  • PET
  • SUVR
  • brain imaging
SNMMI

© 2021 Journal of Nuclear Medicine

Powered by HighWire