PT  - JOURNAL ARTICLE
AU  - Naganawa, Mika
AU  - Gallezot, Jean-Dominique
AU  - Finnema, Sjoerd J.
AU  - Matuskey, David
AU  - Mecca, Adam
AU  - Nabulsi, Nabeel B.
AU  - Labaree, David
AU  - Ropchan, Jim
AU  - Malison, Robert T.
AU  - D’Souza, Deepak Cyril
AU  - Esterlis, Irina
AU  - Detyniecki, Kamil
AU  - van Dyck, Christopher H.
AU  - Huang, Yiyun
AU  - Carson, Richard E.
TI  - Simplified Quantification of <sup>11</sup>C-UCB-J PET Evaluated in a Large Human Cohort
AID  - 10.2967/jnumed.120.243949
DP  - 2021 Mar 01
TA  - Journal of Nuclear Medicine
PG  - 418--421
VI  - 62
IP  - 3
4099  - http://jnm.snmjournals.org/content/62/3/418.short
4100  - http://jnm.snmjournals.org/content/62/3/418.full
SO  - J Nucl Med2021 Mar 01; 62
AB  - 11C-UCB-J ((R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) is a PET tracer for synaptic vesicle glycoprotein 2A, which may be a marker of synaptic density. To simplify the scan protocol, SUV ratios (SUVRs) were compared with model-based nondisplaceable binding potential (BPND) to select the optimal time window in healthy and neuropsychiatric subjects. Methods: In total, 141 scans were acquired for 90 min. Arterial blood sampling and metabolite analysis were conducted. SUVR-1 (centrum semiovale reference region) was computed for six 30-min windows and compared with 1-tissue-compartment model BPND. Simulations were performed to assess the time dependency of SUVR-1. Results: Greater correlation and less bias were observed for SUVR-1 at later time windows for all subjects. Simulations showed that the agreement between SUVR-1 and BPND is time-dependent. Conclusion: The 60- to 90-min period provided the best match between SUVR-1 and BPND (−1% ± 7%); thus, a short scan is sufficient for accurate quantification of 11C-UCB-J–specific binding.