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Research ArticleNeurology

Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort

Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D’Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang and Richard E. Carson
Journal of Nuclear Medicine March 2021, 62 (3) 418-421; DOI: https://doi.org/10.2967/jnumed.120.243949
Mika Naganawa
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
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Jean-Dominique Gallezot
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
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Sjoerd J. Finnema
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
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David Matuskey
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
3Department of Neurology, Yale University, New Haven, Connecticut
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Adam Mecca
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
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Nabeel B. Nabulsi
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
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David Labaree
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
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Jim Ropchan
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
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Robert T. Malison
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
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Deepak Cyril D’Souza
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
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Irina Esterlis
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
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Kamil Detyniecki
3Department of Neurology, Yale University, New Haven, Connecticut
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Christopher H. van Dyck
2Department of Psychiatry, Yale University, New Haven, Connecticut; and
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Yiyun Huang
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
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Richard E. Carson
1PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut
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  • FIGURE 1.
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    FIGURE 1.

    Scatterplots of TTP vs. VT (90 min) (A) and of SUVR-1 vs. BPND (90 min) (B) with regression analysis across all regions in HSs (n = 51). y-axis labels define period for ratio calculation. Table 1 shows regression results. 1TC = 1-tissue-compartment model.

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    FIGURE 2.

    Scatterplots between 1-tissue-compartment (1TC) BPND and SUVR-1 in hippocampus of HSs and ADs (A) and contralateral and ipsilateral hippocampus of epilepsy subjects (B).

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    FIGURE 3.

    Mean ± SD of percentage difference between SUVR-1 and BPND in frontal cortex (A) and hippocampus (B). The 60- to 90-min window is shaded.

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    TABLE 1

    Linear Correlations and Regression Analyses of TTP vs. VT (90 Minutes) and SUVR-1 vs. BPND (90 Minutes) in HSs (n = 51) Across All Regions

    x = VT, y = TTPx = BPND, y = SUVR-1
    Window for TTP and SUVR-1SlopeInterceptR2SlopeInterceptR2
    10–40 min0.992.570.710.620.350.79
    20–50 min1.222.630.750.700.300.86
    30–60 min1.382.150.790.770.240.92
    40–70 min1.501.630.820.840.180.95
    50–80 min1.591.220.840.910.110.96
    60–90 min1.660.920.860.950.090.94
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    TABLE 2

    Percentage Difference in TTP vs. VT (90 Minutes) and SUVR-1 vs. BPND (90 Minutes) in HSs (n = 51)

    ParameterRegion10–40 min20–50 min30–60 min40–70 min50–80 min60–90 min
    TTP vs. VT (90 min)Cerebral cortex12 ± 1936 ± 2149 ± 2159 ± 2166 ± 2172 ± 21
    Subcortical19 ± 2142 ± 2254 ± 2262 ± 2168 ± 2172 ± 21
    Cerebellum26 ± 1848 ± 2059 ± 2067 ± 2072 ± 2077 ± 21
    Centrum semiovale43 ± 2063 ± 2169 ± 2072 ± 2074 ± 1975 ± 20
    Whole brain18 ± 2141 ± 2254 ± 2262 ± 2168 ± 2173 ± 21
    SUVR-1 vs. BPND (90 min)Cerebral cortex−28 ± 8−22 ± 7−16 ± 6−10 ± 5−6 ± 5−2 ± 6
    Subcortical−24 ± 13−18 ± 11−13 ± 8−8 ± 6−5 ± 6−2 ± 7
    Cerebellum−17 ± 8−13 ± 6−9 ± 4−5 ± 4−1 ± 52 ± 7
    Whole brain−25 ± 11−19 ± 9−14 ± 7−9 ± 6−5 ± 6−1 ± 7
    • Data are mean ± SD over all subjects and all regions for each category.

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Journal of Nuclear Medicine: 62 (3)
Journal of Nuclear Medicine
Vol. 62, Issue 3
March 1, 2021
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Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort
Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D’Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang, Richard E. Carson
Journal of Nuclear Medicine Mar 2021, 62 (3) 418-421; DOI: 10.2967/jnumed.120.243949

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Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort
Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, David Matuskey, Adam Mecca, Nabeel B. Nabulsi, David Labaree, Jim Ropchan, Robert T. Malison, Deepak Cyril D’Souza, Irina Esterlis, Kamil Detyniecki, Christopher H. van Dyck, Yiyun Huang, Richard E. Carson
Journal of Nuclear Medicine Mar 2021, 62 (3) 418-421; DOI: 10.2967/jnumed.120.243949
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