TY - JOUR T1 - Simplified Quantification of <sup>11</sup>C-UCB-J PET Evaluated in a Large Human Cohort JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 418 LP - 421 DO - 10.2967/jnumed.120.243949 VL - 62 IS - 3 AU - Mika Naganawa AU - Jean-Dominique Gallezot AU - Sjoerd J. Finnema AU - David Matuskey AU - Adam Mecca AU - Nabeel B. Nabulsi AU - David Labaree AU - Jim Ropchan AU - Robert T. Malison AU - Deepak Cyril D’Souza AU - Irina Esterlis AU - Kamil Detyniecki AU - Christopher H. van Dyck AU - Yiyun Huang AU - Richard E. Carson Y1 - 2021/03/01 UR - http://jnm.snmjournals.org/content/62/3/418.abstract N2 - 11C-UCB-J ((R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) is a PET tracer for synaptic vesicle glycoprotein 2A, which may be a marker of synaptic density. To simplify the scan protocol, SUV ratios (SUVRs) were compared with model-based nondisplaceable binding potential (BPND) to select the optimal time window in healthy and neuropsychiatric subjects. Methods: In total, 141 scans were acquired for 90 min. Arterial blood sampling and metabolite analysis were conducted. SUVR-1 (centrum semiovale reference region) was computed for six 30-min windows and compared with 1-tissue-compartment model BPND. Simulations were performed to assess the time dependency of SUVR-1. Results: Greater correlation and less bias were observed for SUVR-1 at later time windows for all subjects. Simulations showed that the agreement between SUVR-1 and BPND is time-dependent. Conclusion: The 60- to 90-min period provided the best match between SUVR-1 and BPND (−1% ± 7%); thus, a short scan is sufficient for accurate quantification of 11C-UCB-J–specific binding. ER -