Research ArticlePulmonary

Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies

Gjertrud L. Laurell, Pontus Plavén-Sigray, Aurelija Jucaite, Andrea Varrone, Kelly P. Cosgrove, Claus Svarer, Gitte M. Knudsen, Karolinska Schizophrenia Project Consortium, R. Todd Ogden, Francesca Zanderigo, Simon Cervenka, Ansel T. Hillmer and Martin Schain
Journal of Nuclear Medicine March 2021, 62 (3) 412-417; DOI: https://doi.org/10.2967/jnumed.120.243717

Article Figures & Data

Figures

  • Figure1
  • FIGURE 1.
    FIGURE 1.

    Change in outcome measures (VT, VS, and VND) between pre- and postlipopolysaccharide scans in cerebellum (A) and frontal cortex (B). Individual subjects are connected with a line. P values and percentage difference (perc. diff.) between pre- and postlipopolysaccharide scans are shown. HAB = high-affinity binder; MAB = mixed-affinity binder.

  • FIGURE 2.
    FIGURE 2.

    (A and C) Difference in outcome measures (VT, VS, and VND) between controls (Ctrl) and subjects with AUD in cerebellum (A) and frontal cortex (C). (B) Zoomed view of results for VND. P values and percentage difference (perc. diff.) between controls and patients are shown. HAB = high-affinity binder; MAB = mixed-affinity binder.

  • FIGURE 3.
    FIGURE 3.

    (A and C) Difference in outcome measures (VT, VS, and VND) between controls (Ctrl) and FEP patients in cerebellum (A) and frontal cortex (C). (B) Zoomed view of results for VND. P values and percentage difference (perc. diff.) between controls and patients are shown. HAB = high-affinity binder; MAB = mixed-affinity binder.

  • FIGURE 4.
    FIGURE 4.

    (A and C) Difference in outcome measures (VT, VS, and VND) between controls (Ctrl) and PD patients in cerebellum (A) and striatum (C). (B) Zoomed view of results for VND. P values and percentage difference (perc. diff.) between controls and patients are shown. HAB = high-affinity binder; MAB = mixed-affinity binder.

Tables

  • TABLE 1

    Dataset Summary

    Subjects (n)Age
    DatasetGroupHABsMABsHABsMABs
    Sandiego, 2015Lipopolysaccharide3528.0 ± 6.0 (22.7–34.5)23.6 ± 5.1 (19.1–31.1)
    Hillmer, 2017AUD
     Controls8737.4 ± 9.0 (26.3–48.4)32.8 ± 14.6 (19.1–55.6)
     Patients7740.9 ± 7.9 (31.6–55.2)37.9 ± 10.4 (26.9–51.0)
    Collste, 2017FEP
     Controls9727.8 ± 9.3 (22–50)25.7 ± 8.2 (20–43)
     Patients61029.8 ± 8.2 (20–40)27.7 ± 8.8 (19–47)
    Varnäs, 2019PD
     Controls8864.9 ± 4.9 (57.8–71.5)62.1 ± 5.3 (56.1–72.0)
     Patients8863.6 ± 4.3 (57.1–69.1)63.4 ± 6.4 (55.2–73.2)

    • HAB = high-affinity binder; MAB = mixed-affinity binder.

    • Age is given as mean ± SD, followed by range in parentheses.

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