Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies

Gjertrud L. Laurell; Pontus Plavén-Sigray; Aurelija Jucaite; Andrea Varrone; Kelly P. Cosgrove; Claus Svarer; Gitte M. Knudsen; Karolinska Schizophrenia Project Consortium; R. Todd Ogden; Francesca Zanderigo; Simon Cervenka; Ansel T. Hillmer; Martin Schain

doi:10.2967/jnumed.120.243717

Research ArticlePulmonary

Nondisplaceable Binding Is a Potential Confounding Factor in ¹¹C-PBR28 Translocator Protein PET Studies

Gjertrud L. Laurell, Pontus Plavén-Sigray, Aurelija Jucaite, Andrea Varrone, Kelly P. Cosgrove, Claus Svarer, Gitte M. Knudsen, Karolinska Schizophrenia Project Consortium, R. Todd Ogden, Francesca Zanderigo, Simon Cervenka, Ansel T. Hillmer and Martin Schain

Journal of Nuclear Medicine March 2021, 62 (3) 412-417; DOI: https://doi.org/10.2967/jnumed.120.243717

Gjertrud L. Laurell

1Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Pontus Plavén-Sigray

1Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

2Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden

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Aurelija Jucaite

2Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden

3PET Science Centre, Precision Medicine and Genomics, R&D, AstraZeneca, Stockholm, Sweden

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Andrea Varrone

2Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden

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Kelly P. Cosgrove

4PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut

5Department of Psychiatry, Yale University, New Haven, Connecticut

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Claus Svarer

1Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Gitte M. Knudsen

1Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

6Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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7Karolinska Schizophrenia Project Consortium, Stockholm, Sweden

R. Todd Ogden

8Department of Biostatistics, Columbia University, New York, New York

9Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York

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Francesca Zanderigo

8Department of Biostatistics, Columbia University, New York, New York

10Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York; and

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Simon Cervenka

2Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden

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Ansel T. Hillmer

4PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut

5Department of Psychiatry, Yale University, New Haven, Connecticut

11Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut

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Martin Schain

1Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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March 1, 2021

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Nondisplaceable Binding Is a Potential Confounding Factor in ¹¹C-PBR28 Translocator Protein PET Studies

Journal of Nuclear Medicine Mar 2021, 62 (3) 412-417; DOI: 10.2967/jnumed.120.243717

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Nondisplaceable Binding Is a Potential Confounding Factor in ¹¹C-PBR28 Translocator Protein PET Studies

Journal of Nuclear Medicine Mar 2021, 62 (3) 412-417; DOI: 10.2967/jnumed.120.243717

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Keywords

PET
translocator protein
11C-PBR28
simultaneous estimation
kinetic modeling

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