Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleTheranostics

Immune-Checkpoint Blockade Enhances 225Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer

Johannes Czernin, Kyle Current, Christine E. Mona, Lea Nyiranshuti, Firas Hikmat, Caius G. Radu and Katharina Lückerath
Journal of Nuclear Medicine February 2021, 62 (2) 228-231; DOI: https://doi.org/10.2967/jnumed.120.246041
Johannes Czernin
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kyle Current
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christine E. Mona
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lea Nyiranshuti
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Firas Hikmat
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Caius G. Radu
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katharina Lückerath
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Information

vol. 62 no. 2 228-231
DOI 
https://doi.org/10.2967/jnumed.120.246041
PubMed 
32646877

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication March 29, 2020
  • Accepted for publication June 4, 2020
  • Published online January 19, 2021.

Article Versions

  • previous version (July 9, 2020 - 13:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Johannes Czernin,
  2. Kyle Current,
  3. Christine E. Mona,
  4. Lea Nyiranshuti,
  5. Firas Hikmat,
  6. Caius G. Radu and
  7. Katharina Lückerath
  1. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California
  1. For correspondence or reprints contact: Katharina Lückerath, UCLA, 650 Charles E. Young Dr. S., Los Angeles, CA 90095. E-mail: klueckerath{at}mednet.ucla.edu
View Full Text

Statistics from Altmetric.com

Cited By...

  • 62 Citations
  • 56 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Radiotheranostics in oncology: current challenges and emerging opportunities
    Lisa Bodei, Ken Herrmann, Heiko Schöder, Andrew M. Scott, Jason S. Lewis
    Nature Reviews Clinical Oncology 2022 19 8
  • The roles of PD-1/PD-L1 in the prognosis and immunotherapy of prostate cancer
    Yichi Xu, Gendi Song, Shangdan Xie, Wenxiao Jiang, Xin Chen, Man Chu, Xiaoli Hu, Zhi-wei Wang
    Molecular Therapy 2021 29 6
  • Immune Checkpoint Inhibitors in Prostate Cancer
    Shobi Venkatachalam, Taylor R. McFarland, Neeraj Agarwal, Umang Swami
    Cancers 2021 13 9
  • Preclinical and Clinical Status of PSMA-Targeted Alpha Therapy for Metastatic Castration-Resistant Prostate Cancer
    Asta Juzeniene, Vilde Yuli Stenberg, Øyvind Sverre Bruland, Roy Hartvig Larsen
    Cancers 2021 13 4
  • Combination Strategies to Improve Targeted Radionuclide Therapy
    Tiffany G. Chan, Edward O’Neill, Christine Habjan, Bart Cornelissen
    Journal of Nuclear Medicine 2020 61 11
  • mCRPC Patients Receiving 225Ac-PSMA-617 Therapy in the Post–Androgen Deprivation Therapy Setting: Response to Treatment and Survival Analysis
    Mike Sathekge, Frank Bruchertseifer, Mariza Vorster, Ismaheel O. Lawal, Otto Knoesen, Johncy Mahapane, Cindy Davis, Amanda Mdlophane, Alex Maes, Kgomotso Mokoala, Kgomotso Mathabe, Christophe Van, de Wiele, Alfred Morgenstern
    Journal of Nuclear Medicine 2022 63 10
  • Prostate-specific Membrane Antigen Biology in Lethal Prostate Cancer and its Therapeutic Implications
    Beshara Sheehan, Christina Guo, Antje Neeb, Alec Paschalis, Shahneen Sandhu, Johann S. de Bono
    European Urology Focus 2022 8 5
  • Combining Targeted Radionuclide Therapy and Immune Checkpoint Inhibition for Cancer Treatment
    Simone C. Kleinendorst, Egbert Oosterwijk, Johan Bussink, Harm Westdorp, Mark W. Konijnenberg, Sandra Heskamp
    Clinical Cancer Research 2022 28 17
  • Global experience with PSMA-based alpha therapy in prostate cancer
    Mike M. Sathekge, Frank Bruchertseifer, Mariza Vorster, Alfred Morgenstern, Ismaheel O. Lawal
    European Journal of Nuclear Medicine and Molecular Imaging 2021 49 1
  • Single-dose 177Lu-PSMA-617 followed by maintenance pembrolizumab in patients with metastatic castration-resistant prostate cancer: an open-label, dose-expansion, phase 1 trial
    Rahul Aggarwal, Stephanie Starzinski, Ivan de Kouchkovsky, Vadim Koshkin, Rohit Bose, Jonathan Chou, Arpita Desai, Daniel Kwon, Samuel Kaushal, Lauren Trihy, Medini Rastogi, Robin Ippisch, Maya Aslam, Terence Friedlander, Felix Feng, David Oh, Alexander Cheung, Eric Small, Michael Evans, Lawrence Fong, Thomas A Hope
    The Lancet Oncology 2023 24 11

Article usage

Article usage: July 2020 to April 2025

AbstractFullPdf
Jul 2020406068
Aug 2020209026
Sep 2020146025
Oct 2020108020
Nov 2020153034
Dec 2020148015
Jan 2021814134116
Feb 20211243140130
Mar 20213893641
Apr 20212513652
May 20211992650
Jun 20212362952
Jul 20211294760
Aug 20215191120
Sep 2021417865
Oct 2021499287
Nov 20213513972
Dec 2021289555
Jan 2022558380
Feb 2022367644
Mar 202237128145
Apr 202216117115
May 2022389270
Jun 2022245246
Jul 2022216338
Aug 2022277451
Sep 2022306846
Oct 2022237050
Nov 2022396450
Dec 2022304517
Jan 20233010055
Feb 2023289757
Mar 2023419663
Apr 2023184434
May 2023146852
Jun 2023177633
Jul 2023195338
Aug 2023145336
Sep 2023219238
Oct 2023207035
Nov 2023229340
Dec 2023207845
Jan 20244212146
Feb 2024249952
Mar 20242210277
Apr 20244320664
May 20244217961
Jun 20243012055
Jul 20243311345
Aug 20242911358
Sep 20241811566
Oct 20242512679
Nov 20242113085
Dec 20242610264
Jan 20254410954
Feb 20253820574
Mar 20253620094
Apr 20254019693
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 62 (2)
Journal of Nuclear Medicine
Vol. 62, Issue 2
February 1, 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Immune-Checkpoint Blockade Enhances 225Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Immune-Checkpoint Blockade Enhances 225Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer
Johannes Czernin, Kyle Current, Christine E. Mona, Lea Nyiranshuti, Firas Hikmat, Caius G. Radu, Katharina Lückerath
Journal of Nuclear Medicine Feb 2021, 62 (2) 228-231; DOI: 10.2967/jnumed.120.246041

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Immune-Checkpoint Blockade Enhances 225Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer
Johannes Czernin, Kyle Current, Christine E. Mona, Lea Nyiranshuti, Firas Hikmat, Caius G. Radu, Katharina Lückerath
Journal of Nuclear Medicine Feb 2021, 62 (2) 228-231; DOI: 10.2967/jnumed.120.246041
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Visual Abstract
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • Erratum
  • PubMed
  • Google Scholar

Cited By...

  • Current Status of Prostate-specific Membrane Antigen-targeted Alpha Radioligand Therapy in Prostate Cancer
  • Targeted {alpha}-Therapy Using 225Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment
  • Targeted {alpha}-Therapy Using 225Ac Radiolabeled Single-Domain Antibodies Induces Antigen-Specific Immune Responses and Instills Immunomodulation Both Systemically and at the Tumor Microenvironment
  • Combined Targeted Radiopharmaceutical Therapy and Immune Checkpoint Blockade: From Preclinical Advances to the Clinic
  • mCRPC Patients Receiving 225Ac-PSMA-617 Therapy in the Post-Androgen Deprivation Therapy Setting: Response to Treatment and Survival Analysis
  • Response to Combined Peptide Receptor Radionuclide Therapy and Checkpoint Immunotherapy with Ipilimumab Plus Nivolumab in Metastatic Merkel Cell Carcinoma
  • Mechanisms of Resistance to Prostate-Specific Membrane Antigen-Targeted Radioligand Therapy in a Mouse Model of Prostate Cancer
  • Google Scholar

More in this TOC Section

Theranostics

  • Can 177Lu-DOTATATE Kidney Absorbed Doses be Predicted from Pretherapy SSTR PET? Findings from Multicenter Data
  • Determination of the Intralesional Distribution of Theranostic 124I-Omburtamab Convection-Enhanced Delivery in Treatment of Diffuse Intrinsic Pontine Glioma
  • Evidence-Based Clinical Protocols to Monitor Efficacy of [177Lu]Lu-PSMA Radiopharmaceutical Therapy in Metastatic Castration-Resistant Prostate Cancer Using Real-World Data
Show more Theranostics

Basic

  • Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates
  • Optical Navigation of the Drop-In γ-Probe as a Means to Strengthen the Connection Between Robot-Assisted and Radioguided Surgery
  • Synthesis and Preclinical Evaluation of a 68Ga-Labeled Adnectin, 68Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression
Show more Basic

Similar Articles

Keywords

  • 225Ac-PSMA
  • immunotherapy
  • prostate cancer
  • PD-1
  • syngeneic mouse model
SNMMI

© 2025 SNMMI

Powered by HighWire