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Research ArticleTheranostics

Patients Resistant Against PSMA-Targeting α-Radiation Therapy Often Harbor Mutations in DNA Damage-Repair–Associated Genes

Clemens Kratochwil, Frederik L. Giesel, Claus-Peter Heussel, Daniel Kazdal, Volker Endris, Cathleen Nientiedt, Frank Bruchertseifer, Maximilian Kippenberger, Hendrik Rathke, Jonas Leichsenring, Markus Hohenfellner, Alfred Morgenstern, Uwe Haberkorn, Stefan Duensing and Albrecht Stenzinger
Journal of Nuclear Medicine May 2020, 61 (5) 683-688; DOI: https://doi.org/10.2967/jnumed.119.234559
Clemens Kratochwil
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany
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Frederik L. Giesel
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany
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Claus-Peter Heussel
2Thorax Centre, Department of Interventional and Diagnostic Radiology, Heidelberg University Hospital, Heidelberg, Germany
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Daniel Kazdal
3Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
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Volker Endris
3Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
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Cathleen Nientiedt
4Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg, Germany
5Section of Molecular Urooncology, Department of Urology, Heidelberg University Hospital, Heidelberg, Germany
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Frank Bruchertseifer
6Directorate for Nuclear Safety and Security, European Commission–Joint Research Centre, Karlsruhe, Germany
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Maximilian Kippenberger
5Section of Molecular Urooncology, Department of Urology, Heidelberg University Hospital, Heidelberg, Germany
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Hendrik Rathke
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany
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Jonas Leichsenring
3Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
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Markus Hohenfellner
7Department of Urology, Heidelberg University Hospital, Heidelberg, Germany; and
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Alfred Morgenstern
6Directorate for Nuclear Safety and Security, European Commission–Joint Research Centre, Karlsruhe, Germany
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Uwe Haberkorn
1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany
8Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
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Stefan Duensing
5Section of Molecular Urooncology, Department of Urology, Heidelberg University Hospital, Heidelberg, Germany
7Department of Urology, Heidelberg University Hospital, Heidelberg, Germany; and
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Albrecht Stenzinger
3Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
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Article Information

vol. 61 no. 5 683-688
DOI 
https://doi.org/10.2967/jnumed.119.234559
PubMed 
31601699

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication July 31, 2019
  • Accepted for publication September 20, 2019
  • Published online May 1, 2020.

Article Versions

  • previous version (October 10, 2019 - 14:15).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Clemens Kratochwil1,
  2. Frederik L. Giesel1,
  3. Claus-Peter Heussel2,
  4. Daniel Kazdal3,
  5. Volker Endris3,
  6. Cathleen Nientiedt4,5,
  7. Frank Bruchertseifer6,
  8. Maximilian Kippenberger5,
  9. Hendrik Rathke1,
  10. Jonas Leichsenring3,
  11. Markus Hohenfellner7,
  12. Alfred Morgenstern6,
  13. Uwe Haberkorn1,8,
  14. Stefan Duensing*,5,7 and
  15. Albrecht Stenzinger*,3
  1. 1Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany
  2. 2Thorax Centre, Department of Interventional and Diagnostic Radiology, Heidelberg University Hospital, Heidelberg, Germany
  3. 3Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany
  4. 4Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg, Germany
  5. 5Section of Molecular Urooncology, Department of Urology, Heidelberg University Hospital, Heidelberg, Germany
  6. 6Directorate for Nuclear Safety and Security, European Commission–Joint Research Centre, Karlsruhe, Germany
  7. 7Department of Urology, Heidelberg University Hospital, Heidelberg, Germany; and
  8. 8Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
  1. For correspondence or reprints contact: Clemens Kratochwil, Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, Heidelberg, BW 69120, Germany. E-mail: clemens.kratochwil{at}med.uni-heidelberg.de
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 61 (5)
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Patients Resistant Against PSMA-Targeting α-Radiation Therapy Often Harbor Mutations in DNA Damage-Repair–Associated Genes
Clemens Kratochwil, Frederik L. Giesel, Claus-Peter Heussel, Daniel Kazdal, Volker Endris, Cathleen Nientiedt, Frank Bruchertseifer, Maximilian Kippenberger, Hendrik Rathke, Jonas Leichsenring, Markus Hohenfellner, Alfred Morgenstern, Uwe Haberkorn, Stefan Duensing, Albrecht Stenzinger
Journal of Nuclear Medicine May 2020, 61 (5) 683-688; DOI: 10.2967/jnumed.119.234559

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Patients Resistant Against PSMA-Targeting α-Radiation Therapy Often Harbor Mutations in DNA Damage-Repair–Associated Genes
Clemens Kratochwil, Frederik L. Giesel, Claus-Peter Heussel, Daniel Kazdal, Volker Endris, Cathleen Nientiedt, Frank Bruchertseifer, Maximilian Kippenberger, Hendrik Rathke, Jonas Leichsenring, Markus Hohenfellner, Alfred Morgenstern, Uwe Haberkorn, Stefan Duensing, Albrecht Stenzinger
Journal of Nuclear Medicine May 2020, 61 (5) 683-688; DOI: 10.2967/jnumed.119.234559
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