225Ac

Open Access
MHC-I–Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy
Julie Constanzo, Aliasghar Parach, Timothee David, Joshua Karam, Frank Bruchertseifer, Alfred Morgenstern, Marta Jarlier, Manuel Bardiès, Emmanuel Deshayes, Amelie Gudin-de-Vallerin, Florence Boissière-Michot, Evelyne Lopez-Crapez and Jean-Pierre Pouget

Journal of Nuclear Medicine May 1, 2025, 66 (5) 785-792; DOI: https://doi.org/10.2967/jnumed.124.268857
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Radiolabeling and Preclinical Evaluation of Therapeutic Efficacy of ²²⁵Ac-ch806 in Glioblastoma and Colorectal Cancer Xenograft Models
Christian W. Wichmann, Katherine A. Morgan, Zhipeng Cao, Laura D. Osellame, Nancy Guo, Hui Gan, Edward Reilly, Ingrid J.G. Burvenich, Graeme J. O’Keefe, Paul S. Donnelly and Andrew M. Scott

Journal of Nuclear Medicine September 1, 2024, 65 (9) 1456-1462; DOI: https://doi.org/10.2967/jnumed.123.266894
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Deescalated ²²⁵Ac-PSMA-617 Versus ¹⁷⁷Lu/²²⁵Ac-PSMA-617 Cocktail Therapy: A Single-Center Retrospective Analysis of 233 Patients
Hendrik Rathke, Erik Winter, Frank Bruchertseifer, Manuel Röhrich, Frederik Lars Giesel, Uwe Haberkorn, Alfred Morgenstern and Clemens Kratochwil

Journal of Nuclear Medicine July 1, 2024, 65 (7) 1057-1063; DOI: https://doi.org/10.2967/jnumed.123.267206
Open Access
Tandem Isotope Therapy with ²²⁵Ac- and ¹⁷⁷Lu-PSMA-617 in a Murine Model of Prostate Cancer
Catherine Meyer, Andreea Stuparu, Katharina Lueckerath, Jeremie Calais, Johannes Czernin, Roger Slavik and Magnus Dahlbom

Journal of Nuclear Medicine November 1, 2023, 64 (11) 1772-1778; DOI: https://doi.org/10.2967/jnumed.123.265433
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Efficacy of HER2-Targeted Intraperitoneal ²²⁵Ac α-Pretargeted Radioimmunotherapy for Small-Volume Ovarian Peritoneal Carcinomatosis
Sebastian K. Chung, Daniela Burnes Vargas, Christopher S. Chandler, Sumudu Katugampola, Darren R. Veach, Michael R. McDevitt, Shin H. Seo, Brett A. Vaughn, Sara S. Rinne, Blesida Punzalan, Mitesh Patel, Hong Xu, Hong-Fen Guo, Pat B. Zanzonico, Sébastien Monette, Guangbin Yang, Ouathek Ouerfelli, Garrett M. Nash, Andrea Cercek, Edward K. Fung, Roger W. Howell, Steven M. Larson, Sarah M. Cheal and Nai-Kong V. Cheung

Journal of Nuclear Medicine September 1, 2023, 64 (9) 1439-1445; DOI: https://doi.org/10.2967/jnumed.122.265095
Open Access
Evaluation of ¹³⁴Ce/¹³⁴La as a PET Imaging Theranostic Pair for ²²⁵Ac α-Radiotherapeutics
Kondapa Naidu Bobba, Anil P. Bidkar, Niranjan Meher, Cyril Fong, Anju Wadhwa, Suchi Dhrona, Alex Sorlin, Scott Bidlingmaier, Becka Shuere, Jiang He, David M. Wilson, Bin Liu, Youngho Seo, Henry F. VanBrocklin and Robert R. Flavell

Journal of Nuclear Medicine July 1, 2023, 64 (7) 1076-1082; DOI: https://doi.org/10.2967/jnumed.122.265355
Open Access
Signaling Network Response to α-Particle–Targeted Therapy with the ²²⁵Ac-Labeled Minigastrin Analog ²²⁵Ac-PP-F11N Reveals the Radiosensitizing Potential of Histone Deacetylase Inhibitors
Yun Qin, Stefan Imobersteg, Stephan Frank, Alain Blanc, Tanja Chiorazzo, Philipp Berger, Roger Schibli, Martin P. Béhé and Michal Grzmil

Journal of Nuclear Medicine June 1, 2023, 64 (6) 873-879; DOI: https://doi.org/10.2967/jnumed.122.264597
Open Access
Cure of Disseminated Human Lymphoma with [²²⁵Ac]Ac-Ofatumumab in a Preclinical Model
Mark S. Longtine, Kyuhwan Shim, Mark J. Hoegger, Nadia Benabdallah, Diane S. Abou, Daniel L.J. Thorek and Richard L. Wahl

Journal of Nuclear Medicine June 1, 2023, 64 (6) 924-931; DOI: https://doi.org/10.2967/jnumed.122.265167
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Clinical Translation of Targeted α-Therapy: An Evolution or a Revolution?
Benedikt Feuerecker, Clemens Kratochwil, Hojjat Ahmadzadehfar, Alfred Morgenstern, Matthias Eiber, Ken Herrmann and Kelsey L. Pomykala

Journal of Nuclear Medicine May 1, 2023, 64 (5) 685-692; DOI: https://doi.org/10.2967/jnumed.122.265353
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Combination of Carriers with Complementary Intratumoral Microdistributions of Delivered α-Particles May Realize the Promise for ²²⁵Ac in Large, Solid Tumors
Alaina Howe, Omkar Bhatavdekar, Dominick Salerno, Anders Josefsson, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, George Sgouros and Stavroula Sofou

Journal of Nuclear Medicine August 1, 2022, 63 (8) 1223-1230; DOI: https://doi.org/10.2967/jnumed.121.262992

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