High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using 18F-ASEM PET

Jennifer M. Coughlin; Leah H. Rubin; Yong Du; Steven P. Rowe; Jeffrey L. Crawford; Hailey B. Rosenthal; Sarah M. Frey; Erica S. Marshall; Laura K. Shinehouse; Allen Chen; Caroline L. Speck; Yuchuan Wang; Wojciech G. Lesniak; Il Minn; Arnold Bakker; Vidyulata Kamath; Gwenn S. Smith; Marilyn S. Albert; Babak Behnam Azad; Robert F. Dannals; Andrew Horti; Dean F. Wong; Martin G. Pomper

doi:10.2967/jnumed.119.230979

Research ArticleNeurology

High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using ¹⁸F-ASEM PET

Jennifer M. Coughlin, Leah H. Rubin, Yong Du, Steven P. Rowe, Jeffrey L. Crawford, Hailey B. Rosenthal, Sarah M. Frey, Erica S. Marshall, Laura K. Shinehouse, Allen Chen, Caroline L. Speck, Yuchuan Wang, Wojciech G. Lesniak, Il Minn, Arnold Bakker, Vidyulata Kamath, Gwenn S. Smith, Marilyn S. Albert, Babak Behnam Azad, Robert F. Dannals, Andrew Horti, Dean F. Wong and Martin G. Pomper

Journal of Nuclear Medicine March 2020, 61 (3) 423-426; DOI: https://doi.org/10.2967/jnumed.119.230979

Jennifer M. Coughlin

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Leah H. Rubin

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

3Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland

4Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, Maryland; and

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Yong Du

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Steven P. Rowe

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Jeffrey L. Crawford

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Hailey B. Rosenthal

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Sarah M. Frey

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Erica S. Marshall

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Laura K. Shinehouse

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Allen Chen

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Caroline L. Speck

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Yuchuan Wang

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Wojciech G. Lesniak

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Il Minn

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Arnold Bakker

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Vidyulata Kamath

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Gwenn S. Smith

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Marilyn S. Albert

3Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Babak Behnam Azad

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Robert F. Dannals

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Andrew Horti

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Dean F. Wong

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

3Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland

5Department of Neuroscience, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Martin G. Pomper

1Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland

2Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland

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Journal of Nuclear Medicine

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March 1, 2020

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High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using ¹⁸F-ASEM PET

Journal of Nuclear Medicine Mar 2020, 61 (3) 423-426; DOI: 10.2967/jnumed.119.230979

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High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using ¹⁸F-ASEM PET

Journal of Nuclear Medicine Mar 2020, 61 (3) 423-426; DOI: 10.2967/jnumed.119.230979

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nAChR
cholinergic
18F-ASEM
dementia
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High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using ¹⁸F-ASEM PET

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