RT Journal Article
SR Electronic
T1 High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using <sup>18</sup>F-ASEM PET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 423
OP 426
DO 10.2967/jnumed.119.230979
VO 61
IS 3
A1 Jennifer M. Coughlin
A1 Leah H. Rubin
A1 Yong Du
A1 Steven P. Rowe
A1 Jeffrey L. Crawford
A1 Hailey B. Rosenthal
A1 Sarah M. Frey
A1 Erica S. Marshall
A1 Laura K. Shinehouse
A1 Allen Chen
A1 Caroline L. Speck
A1 Yuchuan Wang
A1 Wojciech G. Lesniak
A1 Il Minn
A1 Arnold Bakker
A1 Vidyulata Kamath
A1 Gwenn S. Smith
A1 Marilyn S. Albert
A1 Babak Behnam Azad
A1 Robert F. Dannals
A1 Andrew Horti
A1 Dean F. Wong
A1 Martin G. Pomper
YR 2020
UL http://jnm.snmjournals.org/content/61/3/423.abstract
AB Emerging evidence supports a hypothesized role for the α7-nicotinic acetylcholine receptor (α7-nAChR) in the pathophysiology of Alzheimer’s disease. 18F-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-18F-fluorodibenzo[b,d]thiophene 5,5-dioxide) is a radioligand for estimating the availability of α7-nAChR in the brain in vivo with PET. Methods: In this cross-sectional study, 14 patients with mild cognitive impairment (MCI), a prodromal stage to dementia, and 17 cognitively intact, elderly controls completed 18F-ASEM PET. For each participant, binding in each region of interest was estimated using Logan graphical analysis with a metabolite-corrected arterial input function. Results: Higher 18F-ASEM binding was observed in MCI patients than in controls across all regions, supporting higher availability of α7-nAChR in MCI. 18F-ASEM binding was not associated with verbal memory in this small MCI sample. Conclusion: These data support use of 18F-ASEM PET to examine further the relationship between α7-nAChR availability and MCI.