Discussions with leaders: JNM's series of interviews with leaders in nuclear and molecular imaging and therapy continues with a conversation with David Collingridge, editor-in-chief of The Lancet Oncology and publishing director of The Lancet specialty journals.
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The future of theranostics: Solnes and colleagues provide an overview of already approved theranostic agents and those in development and discuss the potential impacts on cancer and on the field of nuclear medicine.
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18F-FDG or bacteria-targeting tracers? Chen and Dilsizian offer an educational overview of 18F-FDG PET/CT in cardiovascular device infection diagnosis, the strengths and limitations of bacteria-targeting radiotracers for infection imaging, and the pros and cons of 18F-FDG versus bacteria-targeting tracers.
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PET/CT and tumor progression in OPSCC: Wu and colleagues describe development of quantitative imaging features on 18F-FDG PET and contrast CT imaging for use as markers to assess early response and predict outcomes in oropharyngeal squamous cell carcinoma.
Page 327
18F-Choline PET/MRI for prostate biopsy: Davenport and colleagues detail the results of a prospective single-arm clinical trial to determine whether 18F-choline PET/multiparametric MRI can improve the specificity of multiparametric MRI of the prostate in patients with Gleason ≥3+4 prostate cancer.
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Interobserver agreement in 18F-NaF PET/CT: Zacho and colleagues evaluate interobserver agreement on patient and lesion levels for 18F-sodium fluoride PET/CT detection of bone metastases in patients with prostate cancer.
Page 344
First-line 90Y for uveal melanoma: Ponti and colleagues explore the safety and efficacy of 90Y selective internal radiation therapy as first-line therapy in patients with uveal melanoma metastatic to the liver.
Page 350
18F-Fluoroglutamine dynamic PET: Grkovski and colleagues investigate the pharmacokinetic properties of this radiotracer for imaging tumor glutamine flux and metabolism properties in patients with cancer.
Page 357
18F-DOPA PET/CT and neuroblastoma: Piccardo and colleagues evaluate the diagnostic role of 18F-DOPA PET/CT at the time of staging in children with neuroblastoma, its ability to assess treatment response, and its prognostic value.
Page 367
AUC for differentiated thyroid: Donohoe and members of a cross-disciplinary work group present new appropriate use criteria for nuclear medicine in the evaluation and treatment of differentiated thyroid cancer.
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Patient release after 131I therapy: Wu and colleagues report on results from a nationwide survey to evaluate whether practices regarding hospital release of differentiated thyroid cancer patients treated with 131I have changed since publication of NRC Regulatory Issue Summary 2011-01.
Page 397
Total-body PSMA PET for bone staging: Pomykala and colleagues determine the relationship between serum prostate-specific antigen levels and the incidence of bone metastases detected by total-body 68Ga–prostate-specific membrane antigen-11 PET/CT and assess the effect of expanding the imaging field.
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End-of-treatment PET in TB: Lawal and colleagues explore the impact of findings on end-of-treatment 18F-FDG PET/CT on tuberculosis relapse in patients treated with a standard regimen of antituberculous treatment for drug-sensitive pulmonary tuberculosis.
Page 412
PET and inferior colliculi: Speck and colleagues use 18F-FDG PET to evaluate the glucose metabolism of the inferior colliculus and primary auditory cortex in patients with asymmetric hearing loss.
Page 418
18F-ASEM PET in MCI: Coughlin and colleagues use this tracer to examine the relationship between the α7-nicotinic acetylcholine receptor and Alzheimer disease in elderly controls and in patients with mild cognitive impairment.
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64Cu-ATSM as a redox imaging marker: Floberg and colleagues demonstrate that this 64Cu-labeled PET tracer, developed for hypoxia imaging, is dependent on cellular redox state, with or without hypoxia.
Page 427
89Zr-HDL tracer guides CSF1R therapy: Mason and colleagues propose an 89Zr-labeled high-density lipoprotein nanotracer as a means of rapidly monitoring response to immunotherapy targeting tumor-associated macrophages.
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CDK4/6 inhibitor for PET: Ramos and colleagues detail development of an 18F-labeled cyclin-dependent kinase 4/6 inhibitor for breast cancer imaging.
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Tumor-residualizing GRPR-targeted agents: Zhang and colleagues present a strategy using irreversible inhibitors of cysteine cathepsins as trapping agents to increase tumor retention of agonistic and antagonistic pharmacophores targeting the gastrin-releasing peptide receptor.
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Thirty-day total-body PET: Rosenkrans and Cai provide perspective on the recent completion of development of total-body PET scanners and discuss a related article in this issue of JNM.
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30-day 89Zr-antibody PET: Berg and colleagues investigate the technical feasibility and utility of the mini-EXPLORER PET for total-body imaging of 89Zr-labeled antibodies in rhesus monkeys up to 30 days after injection.
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Preclinical PET/CT standardized protocols: McDougald and colleagues assess the variability of current preclinical PET/CT acquisition/reconstruction protocols across multiple centers and propose protocols for standardization of multicenter data for routine scanning in preclinical PET/CT laboratories.
Page 461
Multivendor, multicenter radiomic study: Pfaehler and colleagues detail the impact of harmonized image reconstruction on feature consistency, using 3D printed phantom inserts reflecting realistic tumor shapes and heterogeneity uptake.
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- © 2020 by the Society of Nuclear Medicine and Molecular Imaging.
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