Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans

Nicolas Tournier; Martin Bauer; Verena Pichler; Lukas Nics; Eva-Maria Klebermass; Karsten Bamminger; Peter Matzneller; Maria Weber; Rudolf Karch; Fabien Caillé; Sylvain Auvity; Solène Marie; Walter Jäger; Wolfgang Wadsak; Marcus Hacker; Markus Zeitlinger; Oliver Langer

doi:10.2967/jnumed.118.219972

Research ArticleNeurology

Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate ¹¹C-Metoclopramide Assessed with PET Imaging in Humans

Nicolas Tournier, Martin Bauer, Verena Pichler, Lukas Nics, Eva-Maria Klebermass, Karsten Bamminger, Peter Matzneller, Maria Weber, Rudolf Karch, Fabien Caillé, Sylvain Auvity, Solène Marie, Walter Jäger, Wolfgang Wadsak, Marcus Hacker, Markus Zeitlinger and Oliver Langer

Journal of Nuclear Medicine July 2019, 60 (7) 985-991; DOI: https://doi.org/10.2967/jnumed.118.219972

Nicolas Tournier

1UMR 1023 IMIV, Service Hospitalier Frédéric Joliot, CEA, Inserm, Université Paris Sud, CNRS, Université Paris-Saclay, Orsay, France

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Martin Bauer

2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

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Verena Pichler

3Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Lukas Nics

3Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Eva-Maria Klebermass

3Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Karsten Bamminger

2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

3Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Peter Matzneller

2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

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Maria Weber

2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

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Rudolf Karch

4Centre for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria

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Fabien Caillé

1UMR 1023 IMIV, Service Hospitalier Frédéric Joliot, CEA, Inserm, Université Paris Sud, CNRS, Université Paris-Saclay, Orsay, France

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Sylvain Auvity

1UMR 1023 IMIV, Service Hospitalier Frédéric Joliot, CEA, Inserm, Université Paris Sud, CNRS, Université Paris-Saclay, Orsay, France

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Solène Marie

1UMR 1023 IMIV, Service Hospitalier Frédéric Joliot, CEA, Inserm, Université Paris Sud, CNRS, Université Paris-Saclay, Orsay, France

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Walter Jäger

5Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria

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Wolfgang Wadsak

3Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

6Center for Biomarker Research in Medicine—CBmed GmbH, Graz, Austria; and

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Marcus Hacker

3Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Markus Zeitlinger

2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

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Oliver Langer

2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

3Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

7Biomedical Systems, Center for Health & Bioresources, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria

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Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate ¹¹C-Metoclopramide Assessed with PET Imaging in Humans

Journal of Nuclear Medicine Jul 2019, 60 (7) 985-991; DOI: 10.2967/jnumed.118.219972

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Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate ¹¹C-Metoclopramide Assessed with PET Imaging in Humans

Journal of Nuclear Medicine Jul 2019, 60 (7) 985-991; DOI: 10.2967/jnumed.118.219972

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Keywords

blood-brain barrier
P-glycoprotein
11C-metoclopramide
PET

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Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate ¹¹C-Metoclopramide Assessed with PET Imaging in Humans

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