Discussions with leaders: JNM contributor Ken Herrmann conducts a wide-ranging interview on leadership issues in nuclear and molecular imaging and therapy with Susanne Schaffert of Novartis Oncology.
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CAR T-cell oncologic imaging: Krebs and colleagues provide an overview of cancer immunotherapy based on targeted approaches using chimeric antigen receptor T-cells, including cell tracking, clinical imaging, imaging models, novel constructs, and real-time applications.
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Theranostics in G3 NENs: Waseem and colleagues review the current state of the art in somatostatin receptor theranostics for grade 3 neuroendocrine neoplasms, with special foci on histologic classification and choice of diagnostic imaging approach.
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Cardiac sarcoidosis imaging: Ramirez and colleagues provide an educational overview of current theoretic and practical aspects of cardiac imaging, including PET and MRI, in evaluation of patients with suspected or established cardiac sarcoidosis.
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Immuno-PET in mAb therapy: Reilly offers perspective on current clinical development pathways for monoclonal antibody therapies and previews an article in this issue of JNM on immuno-PET in patients with human epidermal growth factor receptor 3–positive tumors.
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89Zr-Anti-HER3 mAb immuno-PET: Menke-van der Houven van Oordt, McGeoch, and colleagues investigate biodistribution and uptake of 89Zr-labeled GSK2849330, an anti–human epidermal growth factor receptor 3 monoclonal antibody, and evaluate target engagement as a function of antibody mass dose.
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CTT1057 in PCa: Behr, Aggarwal, and colleagues detail a first-in-humans phase I study of CTT1057, an agent based on a phosphoramidate scaffold that irreversibly binds to prostate-specific membrane antigen, in patients with localized and metastatic prostate cancer.
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MEK inhibitor–induced 131I uptake: ElMokh and colleagues target the mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in in vitro studies and a murine model to induce radioiodine uptake for treatment of anaplastic thyroid carcinoma.
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18F-DMFB for melanoma: Pyo and colleagues synthesize a novel 18F-labeled benzamide derivative with high melanin-targeting ability and evaluate its biologic characteristics in small animal models of malignant melanoma.
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P2X7 radioligand PET probe: Fu, Lin, and colleagues evaluate the potential value of 18F-PTTP for targeting P2X7 receptors to differentiate inflammation from tumors, quantify peripheral inflammation, and screen new drugs.
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177Lu-DOTATATE in GEP NETs: Hope and colleagues provide practical guidance on treatment of patients with gastroenteropancreatic neuroendocrine tumors using somatostatin receptor–based peptide receptor radionuclide therapy with 177Lu-DOTATATE, based on recent consensus guidelines.
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PET/CT and MRI in PCa detection: Chen, Zhang, Zhang, and colleagues explore the question of whether 68Ga–prostate-specific membrane antigen PET/CT alone or in combination with multiparametric MR imaging can improve detection of clinically significant prostate cancer.
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Androgen blockade and PSMA PET: Emmett and colleagues evaluate the effect of androgen blockade treatment on 68Ga–prostate-specific membrane antigen–11 PET imaging in hormone-naive and castrate-resistant men with metastatic prostate cancer.
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177Lu-PRLT in metastatic PCa: Barber, Singh, and colleagues assess clinical outcomes in 177Lu–prostate-specific membrane antigen–targeted therapy in taxane chemotherapy–pretreated and –naïve patients with metastatic castration-resistant prostate cancer.
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PSMA PET/CT vs. CT in PCa: Schmidt-Hegemann and colleagues report on a retrospective study determining the comparative effects of 68Ga–prostate-specific membrane antigen PET/CT and standard CT-based imaging on radiotherapeutic approaches to prostate cancer.
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PET in PCa LN metastases: Jilg and colleagues use 18F-choline and 68Ga–prostate-specific membrane antigen PET/CT before lymphadenectomy in prostate cancer to determine relationships between lymph node metastatic rate and size of tumor deposits in metastases.
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SVCA and 11C-PBR28: Zanotti-Fregonara and colleagues test a supervised clustering algorithm in Alzheimer disease, mild cognitive impairment, and controls injected with the translocator protein 11C-PBR28 and compare kinetic modeling results obtained with those from arterial input function.
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Efflux enhancement by ABCB1: Tournier, Bauer, and colleagues perform PET with the weak P-glycoprotein substrate 11C-metoclopramide in humans to elucidate the effect of ABCB1 function on its brain kinetics.
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Brain BACE1 in NHPs: Takano and colleagues quantitatively evaluate regional brain distribution of 18F-PF-06684511 under baseline and blocking conditions, assess target occupancy of β-secretase 1 inhibitors in nonhuman primates, and use whole-body PET to estimate effective radiation doses.
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PET/CT in bacteremia treatment: Berrevoets and colleagues investigate the safety of a shorter duration of treatment in patients with high-risk Staphylococcus aureus bacteremia without signs of metastatic infection, determined by 18F-FDG PET/CT and echocardiography.
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Toward novel 18F-amino acids tracers: Nodwell and colleagues examine in in vitro and in vivo studies the structure–activity relationships of a series of 18F-labeled amino acids predicted to be substrates of the large, neutral L-type amino acid transporter system..
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Improved minigastrin for theranostic use: Klingler and colleagues present a new minigastrin analog, DOTA-MGS5, with site-specific C terminus modifications showing a highly optimized targeting profile and promise in cholecystokinin-2 receptor–expressing malignancies.
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18F-AlF-PSMA-11 PET/CT: Lütje and colleagues compare the prostate-specific membrane antigen (PSMA)–targeting characteristics of PSMA-11, radiolabeled on the basis of chelation of 18F-AlF, with those of 68Ga-PSMA-11 in imaging PSMA-expressing xenografts.
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Visualization of KOR active state: Li and colleagues report on development and evaluation of 11C-EKAP, compare it with 11C-GR103545 in PET imaging of κ opioid receptors in nonhuman primates, and describe the new tracer’s potential in theranostic applications.
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Vision PET/CT system: Sluis and colleagues report on the performance of the Biograph Vision digital PET/CT system according to the NEMA NU 2-2012 standard for reliability, reproducibility, and intersystem comparability.
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- © 2019 by the Society of Nuclear Medicine and Molecular Imaging.