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Research ArticleRadiochemistry

Synthesis and Biologic Evaluation of a Novel 18F-Labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression

David J. Donnelly, R. Adam Smith, Paul Morin, Daša Lipovšek, Jochem Gokemeijer, Daniel Cohen, Virginie Lafont, Tritin Tran, Erin L. Cole, Martin Wright, Joonyoung Kim, Adrienne Pena, Daniel Kukral, Douglas D. Dischino, Patrick Chow, Jinping Gan, Olufemi Adelakun, Xi-Tao Wang, Kai Cao, David Leung, Samuel J. Bonacorsi and Wendy Hayes
Journal of Nuclear Medicine March 2018, 59 (3) 529-535; DOI: https://doi.org/10.2967/jnumed.117.199596
David J. Donnelly
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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R. Adam Smith
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Paul Morin
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Daša Lipovšek
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Jochem Gokemeijer
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Daniel Cohen
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Virginie Lafont
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Tritin Tran
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Erin L. Cole
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Martin Wright
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Joonyoung Kim
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Adrienne Pena
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Daniel Kukral
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Douglas D. Dischino
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Patrick Chow
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Jinping Gan
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Olufemi Adelakun
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Xi-Tao Wang
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Kai Cao
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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David Leung
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Samuel J. Bonacorsi Jr.
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Wendy Hayes
Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Journal of Nuclear Medicine: 59 (3)
Journal of Nuclear Medicine
Vol. 59, Issue 3
March 1, 2018
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Synthesis and Biologic Evaluation of a Novel 18F-Labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression
David J. Donnelly, R. Adam Smith, Paul Morin, Daša Lipovšek, Jochem Gokemeijer, Daniel Cohen, Virginie Lafont, Tritin Tran, Erin L. Cole, Martin Wright, Joonyoung Kim, Adrienne Pena, Daniel Kukral, Douglas D. Dischino, Patrick Chow, Jinping Gan, Olufemi Adelakun, Xi-Tao Wang, Kai Cao, David Leung, Samuel J. Bonacorsi, Wendy Hayes
Journal of Nuclear Medicine Mar 2018, 59 (3) 529-535; DOI: 10.2967/jnumed.117.199596

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Synthesis and Biologic Evaluation of a Novel 18F-Labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression
David J. Donnelly, R. Adam Smith, Paul Morin, Daša Lipovšek, Jochem Gokemeijer, Daniel Cohen, Virginie Lafont, Tritin Tran, Erin L. Cole, Martin Wright, Joonyoung Kim, Adrienne Pena, Daniel Kukral, Douglas D. Dischino, Patrick Chow, Jinping Gan, Olufemi Adelakun, Xi-Tao Wang, Kai Cao, David Leung, Samuel J. Bonacorsi, Wendy Hayes
Journal of Nuclear Medicine Mar 2018, 59 (3) 529-535; DOI: 10.2967/jnumed.117.199596
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Keywords

  • PD-L1
  • PET
  • PD-1/PD-L1 checkpoint inhibitor
  • 18F-labeled adnectin
  • 18F-BMS-986192
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