Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects

Dean F. Wong; Robert A. Comley; Hiroto Kuwabara; Paul B. Rosenberg; Susan M. Resnick; Susanne Ostrowitzki; Cristina Vozzi; Frank Boess; Esther Oh; Constantine G. Lyketsos; Michael Honer; Luca Gobbi; Gregory Klein; Noble George; Lorena Gapasin; Kelly Kitzmiller; Josh Roberts; Jeff Sevigny; Ayon Nandi; James Brasic; Chakradhar Mishra; Madhav Thambisetty; Abhay Moghekar; Anil Mathur; Marilyn Albert; Robert F. Dannals; Edilio Borroni

doi:10.2967/jnumed.118.209916

Research ArticleNeurology

Characterization of 3 Novel Tau Radiopharmaceuticals, ¹¹C-RO-963, ¹¹C-RO-643, and ¹⁸F-RO-948, in Healthy Controls and in Alzheimer Subjects

Dean F. Wong, Robert A. Comley, Hiroto Kuwabara, Paul B. Rosenberg, Susan M. Resnick, Susanne Ostrowitzki, Cristina Vozzi, Frank Boess, Esther Oh, Constantine G. Lyketsos, Michael Honer, Luca Gobbi, Gregory Klein, Noble George, Lorena Gapasin, Kelly Kitzmiller, Josh Roberts, Jeff Sevigny, Ayon Nandi, James Brasic, Chakradhar Mishra, Madhav Thambisetty, Abhay Moghekar, Anil Mathur, Marilyn Albert, Robert F. Dannals and Edilio Borroni

Journal of Nuclear Medicine December 2018, 59 (12) 1869-1876; DOI: https://doi.org/10.2967/jnumed.118.209916

Dean F. Wong

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

2Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland

3Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland

4Department of Neurology, Johns Hopkins University, Baltimore, Maryland

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Robert A. Comley

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Hiroto Kuwabara

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Paul B. Rosenberg

2Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland

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Susan M. Resnick

6Lab of Behavioral Neuroscience, NIH-NIA IRP, Baltimore, Maryland; and

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Susanne Ostrowitzki

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Cristina Vozzi

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Frank Boess

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Esther Oh

7Department of Medicine, Johns Hopkins University, Baltimore, Maryland

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Constantine G. Lyketsos

2Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland

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Michael Honer

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Luca Gobbi

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Gregory Klein

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Noble George

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Lorena Gapasin

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Kelly Kitzmiller

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Josh Roberts

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Jeff Sevigny

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Ayon Nandi

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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James Brasic

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Chakradhar Mishra

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Madhav Thambisetty

6Lab of Behavioral Neuroscience, NIH-NIA IRP, Baltimore, Maryland; and

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Abhay Moghekar

4Department of Neurology, Johns Hopkins University, Baltimore, Maryland

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Anil Mathur

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Marilyn Albert

3Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland

4Department of Neurology, Johns Hopkins University, Baltimore, Maryland

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Robert F. Dannals

1Section of High Resolution Brain PET, Department of Radiology and Radiological Sciences, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, Maryland

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Edilio Borroni

5Pharma Research and Early Development, Hoffmann-La Roche, Basel, Switzerland

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Characterization of 3 Novel Tau Radiopharmaceuticals, ¹¹C-RO-963, ¹¹C-RO-643, and ¹⁸F-RO-948, in Healthy Controls and in Alzheimer Subjects

Journal of Nuclear Medicine Dec 2018, 59 (12) 1869-1876; DOI: 10.2967/jnumed.118.209916

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Characterization of 3 Novel Tau Radiopharmaceuticals, ¹¹C-RO-963, ¹¹C-RO-643, and ¹⁸F-RO-948, in Healthy Controls and in Alzheimer Subjects

Journal of Nuclear Medicine Dec 2018, 59 (12) 1869-1876; DOI: 10.2967/jnumed.118.209916

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Characterization of 3 Novel Tau Radiopharmaceuticals, ¹¹C-RO-963, ¹¹C-RO-643, and ¹⁸F-RO-948, in Healthy Controls and in Alzheimer Subjects

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