Research ArticleEndocrinology
Dissociation Between Brown Adipose Tissue 18F-FDG Uptake and Thermogenesis in Uncoupling Protein 1–Deficient Mice
Mohammed K. Hankir, Mathias Kranz, Susanne Keipert, Juliane Weiner, Sille G. Andreasen, Matthias Kern, Marianne Patt, Nora Klöting, John T. Heiker, Peter Brust, Swen Hesse, Martin Jastroch and Wiebke K. Fenske
Journal of Nuclear Medicine July 2017, 58 (7) 1100-1103; DOI: https://doi.org/10.2967/jnumed.116.186460
Mohammed K. Hankir
1Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, University of Leipzig, Leipzig, Germany
Mathias Kranz
2Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz Centre Dresden-Rossendorf, Leipzig, Germany
Susanne Keipert
3Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherburg, Germany
Juliane Weiner
4Collaborative Research Center for Obesity Mechanisms, University of Leipzig, Leipzig, Germany; and
Sille G. Andreasen
1Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, University of Leipzig, Leipzig, Germany
Matthias Kern
1Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, University of Leipzig, Leipzig, Germany
Marianne Patt
5Department of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany
Nora Klöting
1Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, University of Leipzig, Leipzig, Germany
John T. Heiker
4Collaborative Research Center for Obesity Mechanisms, University of Leipzig, Leipzig, Germany; and
Peter Brust
2Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz Centre Dresden-Rossendorf, Leipzig, Germany
Swen Hesse
1Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, University of Leipzig, Leipzig, Germany
5Department of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany
Martin Jastroch
3Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherburg, Germany
Wiebke K. Fenske
1Integrated Research and Treatment Centre for Adiposity Diseases, Department of Medicine, University of Leipzig, Leipzig, Germany
FIGURE 2.
FIGURE 2.
(A) Representative thermal images of WT (top) and UCP1 KO (bottom) mice taken 15 min after CL 316, 243 injections. (B) Defective BAT thermogenesis in response to adrenergic stimulation in UCP1 KO mice. Data points represent mean ± SEM of 4 animals per group. *P < 0.05. ***P < 0.001.
In this issue
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
Dissociation Between Brown Adipose Tissue 18F-FDG Uptake and Thermogenesis in Uncoupling Protein 1–Deficient Mice
Mohammed K. Hankir, Mathias Kranz, Susanne Keipert, Juliane Weiner, Sille G. Andreasen, Matthias Kern, Marianne Patt, Nora Klöting, John T. Heiker, Peter Brust, Swen Hesse, Martin Jastroch, Wiebke K. Fenske
Journal of Nuclear Medicine Jul 2017, 58 (7) 1100-1103; DOI: 10.2967/jnumed.116.186460
Dissociation Between Brown Adipose Tissue 18F-FDG Uptake and Thermogenesis in Uncoupling Protein 1–Deficient Mice
Mohammed K. Hankir, Mathias Kranz, Susanne Keipert, Juliane Weiner, Sille G. Andreasen, Matthias Kern, Marianne Patt, Nora Klöting, John T. Heiker, Peter Brust, Swen Hesse, Martin Jastroch, Wiebke K. Fenske
Journal of Nuclear Medicine Jul 2017, 58 (7) 1100-1103; DOI: 10.2967/jnumed.116.186460
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