Article Figures & Data
Figures
- FIGURE 1.
The effect of population-based (PB) approach to adjust input functions (IF) with delayed centrifugation (A and B) and SUVs of IF and brain region of MABs (A and C) and HABs (B and D). (A and B) SUVs of MAB (subject 6) and HAB (subject 3), separately, both with delayed centrifugation of blood samples. 2TCM fitting to neocortex using the input functions (red curves) was also given. (C and D) SUVs of MAB (subject 10) and HAB (subject 14), both with immediate centrifugation of blood samples.
- FIGURE 2.
Effect of immediate centrifugation of blood samples on PoB.
- FIGURE 3.
Cerebellar brain SUVmean (A), SUVmean 60–90 min (B), and VT (C) categorized by genotype: MAB and HAB.
- FIGURE 4.
Brain SUVmean of typical MAB (subject 12) and HAB (subject 11).
Tables
Subject no. Sex Age (y) Body weight (kg) TSPO genotype Injected activity (MBq) Scan interval (d) Centrifugation Purity (%) Plasma control (%) 1 M 61 80 MAB 120.9 21 Delayed 96.1 95.4 117.8 93.5 91.4 2 M 70 92 MAB 112.2 42 Delayed 95.4 95.4 123.6 94.9 93.8 3 M 59 76.5 HAB 118.1 35 Delayed 96.4 94.7 112.0 94.9 93.2 4 F 38 110 HAB 116.3 28 Delayed 96.0 95.0 114.3 90.7 88.4 5 F 62 70 HAB 119.0 42 Delayed 96.1 95.1 119.4 96.6 94.0 6 F 58 50 MAB 116.0 28 Delayed 96.1 96.2 119.7 95.3 91.4 7 F 68 87 HAB 124.8 56 Delayed 92.3 90.1 115.1 95.2 90.5 8 M 52 94 HAB 118.5 56 Delayed 98.1 93.8 124.1 89.8 88.5 9 M 42 80 MAB 118.8 28 Immediate 95.7 94.6 115.8 93.4 90.3 10 F 45 86.2 MAB 117.4 56 Immediate 95.4 94.6 114.1 94.9 94.7 11 M 35 100 HAB 119.9 56 Immediate 93.0 93.2 114.4 90.7 89.9 12 F 40 73 MAB 112.0 7 Immediate 92.8 91.8 130.7 94.7 94.1 13 M 24 95.6 MAB 115.4 14 Immediate 94.4 92.2 116.0 92.0 90.2 14 F 69 83 MAB 123.0 28 Immediate 94.5 92.7 127.1 94.4 90.4 15 F 30 68 HAB 105.8 42 Immediate 91.0 82.9 116.0 91.1 88.1 16 F 34 74.2 HAB 118.4 28 Immediate Not available Not available 116.3 Not available Not available Mean ± SD 49 ± 15 82.5 ± 14.4 117.9 ± 4.9 35 ± 15 93.4 ± 1.7 91.4 ± 3.2 Region VT of DC* (n = 8) VT of IC† (n = 8) VT of all subjects (n = 16) Brain uptake (n = 16) PD (%) Absolute PD (%) ICC PD (%) Absolute PD (%) ICC PD (%) Absolute PD (%) ICC of MABs ICC of HABs ICC of all PD (%) Absolute PD (%) ICC of MABs ICC of HABs ICC of all Midbrain 2.8 ± 14.5 12.4 0.96 −1.5 ± 15.6 11.8 0.86 0.6 ± 14.8 12.1 0.41 0.91 0.93 −2.5 ± 11.5 10.1 0.72 0.39 0.71 Thalamus 11.0 ± 10.5 12.8 0.94 −12.3 ± 13.3 12.7 0.86 −0.7 ± 16.7 12.8 0.68 0.84 0.90 −4.7 ± 14.6 11.6 0.74 0.53 0.71 Pons −2.3 ± 14.2 9.6 0.90 −8.2 ± 23.8 18.9 0.72 −5.3 ± 19.2 14.2 0.54 0.60 0.82 −2.7 ± 12.4 11.0 0.81 0.52 0.77 Pallidostriatum 5.8 ± 21.9 17.6 0.85 −7.0 ± 19.0 14.1 0.87 −0.6 ± 20.9 15.8 0.22 0.79 0.85 −2.2 ± 13.7 11.1 0.79 0.50 0.74 Hippocampus 14.9 ± 17.3 15.7 0.75 −5.9 ± 11.8 9.7 0.91 4.5 ± 17.9 12.7 0.58 0.78 0.83 −2.0 ± 15.2 12.3 0.57 0.23 0.56 Cerebellum 9.6 ± 9.4 10.2 0.94 −4.9 ± 10.0 8.2 0.96 2.3 ± 12.0 9.2 0.76 0.88 0.95 −1.5 ± 9.4 7.8 0.90 0.45 0.87 Neocortex 5.8 ± 12.6 10.2 0.92 −3.2 ± 12.8 10.5 0.92 1.3 ± 13.2 10.4 0.88 0.79 0.92 −2.8 ± 9.6 8.5 0.91 0.57 0.85
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