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Journal of Nuclear Medicine

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Research ArticleClinical Investigations

Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding

Qi Guo, Alessandro Colasanti, David R. Owen, Mayca Onega, Aruloly Kamalakaran, Idriss Bennacef, Paul M. Matthews, Eugenii A. Rabiner, Federico E. Turkheimer and Roger N. Gunn
Journal of Nuclear Medicine November 2013, 54 (11) 1915-1923; DOI: https://doi.org/10.2967/jnumed.113.121020
Qi Guo
1Centre for Imaging Sciences, Imanova, London, United Kingdom
2IoP, King’s College London, London, United Kingdom
3Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom; and
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Alessandro Colasanti
1Centre for Imaging Sciences, Imanova, London, United Kingdom
3Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom; and
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David R. Owen
3Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom; and
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Mayca Onega
1Centre for Imaging Sciences, Imanova, London, United Kingdom
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Aruloly Kamalakaran
1Centre for Imaging Sciences, Imanova, London, United Kingdom
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Idriss Bennacef
4GlaxoSmithKline, Brentford, Middlesex, United Kingdom
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Paul M. Matthews
3Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom; and
4GlaxoSmithKline, Brentford, Middlesex, United Kingdom
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Eugenii A. Rabiner
1Centre for Imaging Sciences, Imanova, London, United Kingdom
2IoP, King’s College London, London, United Kingdom
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Federico E. Turkheimer
2IoP, King’s College London, London, United Kingdom
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Roger N. Gunn
1Centre for Imaging Sciences, Imanova, London, United Kingdom
3Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom; and
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Journal of Nuclear Medicine: 54 (11)
Journal of Nuclear Medicine
Vol. 54, Issue 11
November 1, 2013
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Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding
Qi Guo, Alessandro Colasanti, David R. Owen, Mayca Onega, Aruloly Kamalakaran, Idriss Bennacef, Paul M. Matthews, Eugenii A. Rabiner, Federico E. Turkheimer, Roger N. Gunn
Journal of Nuclear Medicine Nov 2013, 54 (11) 1915-1923; DOI: 10.2967/jnumed.113.121020

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Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding
Qi Guo, Alessandro Colasanti, David R. Owen, Mayca Onega, Aruloly Kamalakaran, Idriss Bennacef, Paul M. Matthews, Eugenii A. Rabiner, Federico E. Turkheimer, Roger N. Gunn
Journal of Nuclear Medicine Nov 2013, 54 (11) 1915-1923; DOI: 10.2967/jnumed.113.121020
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Keywords

  • 18F-PBR111
  • TSPO
  • specific binding
  • neuroinflammation
  • rs6971 polymorphism
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