Article Figures & Data
Figures
- FIGURE 1.
CLuptake (mL/g/min) of 11C-verapamil between haplotypes TTT (1236TT, 2677TT, and 3435TT) vs. CGC (1236CC, 2677GG, and 3435CC). The mean of each haplotype is indicated by a horizontal bar.
- FIGURE 2.
Time course of percentage of unmetabolized 11C-verapamil in plasma between haplotypes (1236TT, 2677TT, and 3435TT [○] vs. 1236CC, 2677GG, and 3435CC [•]). Error bars are shown as 1 SD.
- FIGURE 3.
Correlation between CLuptake of integration plot and K1 (A), k2 (B), and DV (C) in 1-input, 1-compartment model. Linear regression is shown when correlation is significant.
- FIGURE 4.
Correlation between CLuptake of integration plot and AUCratio_uncorrected (A) and AUCratio_corrected (B).
Tables
- TABLE 1
Pharmacokinetic Parameters of Intravenously Administered 11C-Verapamil of Haplotypes of MDR1 Genes
Pharmacokinetic parameter TTT CGC AUCplasma (%dose × min/mL) (∼3 min) 0.0206 ± 0.0058 0.0217 ± 0.0043 AUCcortex (%dose × min/g) (∼3 min) 0.0031 ± 0.0006 0.0031 ± 0.0005 Cmax_cortex (%dose/g) 0.00132 ± 0.0003 0.00128 ± 0.0002 Tmax_cortex (min) 0.31 ± 0.07 0.35 ± 0.13 CLuptake (mL/g/min) 0.053 ± 0.011 0.051 ± 0.011 VE (mL/g) 0.0756 ± 0.0130 0.0700 ± 0.0108 AUCplasma = area under plasma concentration curve; AUCcortex = area under time–activity curve of ROIs in cortex; Cmax_cortex = maximal concentration in cortex; Tmax_cortex = time at maximal concentration in cortex; CLuptake = brain uptake clearance based on plasma concentration of 11C-verapamil; VE = initial DV in brain at time 0.
AUC values were calculated from 0 to 3 min after injection. TTT consisted of subjects with MDR1 genes of 1236TT, 2677TT, and 3435TT, whereas CGC consisted of subjects with MDR1 genes of 1236CC, 2677GG, and 3435CC. Each value is mean ± SD.
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