OtherClinical Investigations

Ursodeoxycholic Acid–Augmented Hepatobiliary Scintigraphy in the Evaluation of Neonatal Jaundice

Ujjal Poddar, Anish Bhattacharya, Babu R. Thapa, Bhagwant R. Mittal and Kartar Singh
Journal of Nuclear Medicine September 2004, 45 (9) 1488-1492;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    99mTc-Mebrofenin scintigraphy of 45-d-old infant with neonatal jaundice before (A) and after (B) UDCA premedication. Drainage of tracer into the intestine (arrow) is seen on the post-UDCA study at 5 h and later. ant = anterior; post = posterior.

  • FIGURE 2.
    FIGURE 2.

    (A) Pre-UDCA 99mTc-mebrofenin hepatobiliary scintigraphy of 2-mo-old infant shows no detectable intestinal clearance of tracer up to 24 h. (B) Post-UDCA study shows intestinal clearance (arrow) by 3 h, which increases at 5 and 24 h. ant = anterior; post = posterior.

  • FIGURE 3.
    FIGURE 3.

    (A) In a 40-d-old infant with severe hepatic dysfunction, pre-UDCA 99mTc-mebrofenin study shows high background activity, with no detectable tracer clearance into the intestine. (B) Post-UDCA study of same infant shows tracer draining into the intestine (arrow) by 1 h. ant = anterior.

Tables

  • TABLE 1

    Causes of Neonatal Jaundice in Study Population

    CauseNo. of cases (n = 51)
    Extrahepatic biliary atresia16 (31.4%)
    Neonatal hepatitis35 (68.6%)
        Galactosemia08
        Sepsis/urinary tract infection16
        Cytomegalovirus01
        Progressive familial intrahepatic cholestasis01
        Idiopathic09
  • TABLE 2

    Accuracy of Diagnostic Tests in Study Population (n = 51)

    Test no.TestAccuracy*
    1Abdominal ultrasonography74.5%
    2Pre-UDCA scintigraphy68.6%†
    3Post-UDCA scintigraphy92.1%†
    4Liver biopsy100%

    • ↵* Accuracy = accurately diagnosed cases/performed cases × 100.

    • ↵† P < 0.001 between tests 2 and 3.

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