Prognostic Value of PET Using 18F-FDG in Hodgkin’s Disease for Posttreatment Evaluation

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FIGURE 1.
Kaplan–Meier estimate of disease-free interval in 36 patients with negative ¹⁸F-FDG PET and 12 patients with positive ¹⁸F-FDG PET. Time intervals are in days.
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FIGURE 2.
Kaplan–Meier estimate of disease-free interval. ¹⁸F-FDG PET was performed in first 30 d after chemotherapy (A) and 91–365 d after chemotherapy (B). Time intervals are in days.
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FIGURE 3.
Kaplan–Meier estimate of disease-free interval in patients with positive CT or ¹⁸F-FDG PET studies. In patients with either negative CT or PET study, survival curves were almost identical and showed very low rate of relapse. Time intervals are in days.

TABLE 1

Patient Characteristics

Characteristic	No. of patients
Total no. of cases	48
Males	24
Females	24
Age (y)
Median	38
Range	17–78
Ann Arbor clinical stage
I	2
II	23
III	15
IV	8
Treatment
Chemotherapy alone	17
Chemotherapy and radiotherapy	31
No. of cycles (mean)	7
Time interval between end of chemotherapy and PET (d)
Median	58
Range	0–1,639
Follow-up duration from end of chemotherapy (d)
Median	486
Range	15–1,861
Follow-up duration after PET (d)
Median	210
Range	1–875

TABLE 2

Relationships Between PET Scan Results, Clinical Outcome, and Predictive Values

Time between PET scan and last cycle of chemotherapy (d)	¹⁸F-FDG PET	Relapse			Predictive values (%)
Time between PET scan and last cycle of chemotherapy (d)	¹⁸F-FDG PET			Positive	Predictive values (%)	Negative
0–30	Positive (n = 6)	6	0	100
	Negative (n = 8)	2	6	75
31–90	Positive (n = 1)	1	0	100
	Negative (n = 12)	1	11	92
91–365	Positive (n = 5)	4	1	80
	Negative (n = 8)	0	8	100
>365	Positive (n = 0)	0	0	NA*
	Negative (n = 8)	0	8	100

Imaging	No.	True +	True −	False +	False −	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
PET	48	11	33	1	3	79*	97^†	92^‡	92*	92^†
CT	32	10	8	12	2	83*	40^†	45^‡	80*	56^†