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Journal of Nuclear Medicine

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OtherBasic Science Investigations

Quantitative Gated PET for the Assessment of Left Ventricular Function in Small Animals

Etienne Croteau, François Bénard, Jules Cadorette, Marie-Ève Gauthier, Antonio Aliaga, M’hamed Bentourkia and Roger Lecomte
Journal of Nuclear Medicine October 2003, 44 (10) 1655-1661;
Etienne Croteau
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François Bénard
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Jules Cadorette
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Marie-Ève Gauthier
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Antonio Aliaga
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M’hamed Bentourkia
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Roger Lecomte
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  • FIGURE 1.
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    FIGURE 1.

    Schematic of heart phantom showing variable-volume internal chamber filled with water and sealed, fixed-volume dual-layer wall filled with 18F-FDG. Phantom can accommodate endocardial volume ranging from 150 to 1,000 μL. Shown on right is example of systolic (300 μL) and diastolic (900 μL) images extracted by QGS analysis of simulated series of gated PET images of phantom. SA = short axis; HLA = horizontal long axis; VLA = vertical long axis.

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    FIGURE 2.

    Results of QGS-analyzed, ECG-gated 18F-FDG PET of normal and infarcted rats using Sherbrooke small-animal PET scanner. EF = ejection fraction.

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    FIGURE 3.

    Correlation between endocardial volume of cardiac phantom and volume determined using QGS: linear regression analysis of measurements performed in triplicate (A) and Bland–Altman plot (B). Sy.x = SEE.

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    FIGURE 4.

    Correlation between ventricular end-systolic and end-diastolic volumes measured by gated PET and echocardiography in healthy rats (n = 11): linear regression (A) and Bland–Altman plot (B). Echo = echocardiography; Sy.x = SEE.

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    FIGURE 5.

    Correlation between ventricular end-systolic and end-diastolic volumes measured by gated PET and echocardiography in infarcted (n = 15) and septic (n = 4) rats: linear regression (A) and Bland–Altman plot (B). Echo = echocardiography; Sy.x = SEE.

  • FIGURE 6.
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    FIGURE 6.

    Correlation between LVEF measured by gated PET and echocardiography for normal (n = 11), infarcted (n = 15), and septic (n = 4) rats: linear regression (A) and Bland–Altman plot (B). Echo = echocardiography; Sy.x = SEE.

Tables

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    TABLE 1

    LVVs and LVEFs

    InstrumentationRatLVEF (%)ESV (μL)EDV (μL)
    PET (QGS)*Normal† (n = 11)83.2 ± 8.090 ± 57496 ± 135
    Infarct† (n = 15)54.6 ± 15.9353 ± 174730 ± 208
    Echocardiography*Normal (n = 11)81.6 ± 6.094 ± 60502 ± 171
    Infarct (n = 15)54.2 ± 13.3479 ± 375968 ± 559
    • ↵* P < 0.001 (unpaired t test between normal and infarct).

    • ↵† P > 0.5 (paired t test between LVEF PET and echocardiography).

    • ESV = end-systolic volume; EDV = end-diastolic volume.

    • Data are mean ± SD.

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Journal of Nuclear Medicine
Vol. 44, Issue 10
October 1, 2003
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Quantitative Gated PET for the Assessment of Left Ventricular Function in Small Animals
Etienne Croteau, François Bénard, Jules Cadorette, Marie-Ève Gauthier, Antonio Aliaga, M’hamed Bentourkia, Roger Lecomte
Journal of Nuclear Medicine Oct 2003, 44 (10) 1655-1661;

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Quantitative Gated PET for the Assessment of Left Ventricular Function in Small Animals
Etienne Croteau, François Bénard, Jules Cadorette, Marie-Ève Gauthier, Antonio Aliaga, M’hamed Bentourkia, Roger Lecomte
Journal of Nuclear Medicine Oct 2003, 44 (10) 1655-1661;
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