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OtherCLINICAL INVESTIGATIONS

Clinical Outcome of Patients with Previous Myocardial Infarction and Left Ventricular Dysfunction Assessed with Myocardial 99mTc-MIBI SPECT and 18F-FDG PET

Xiaoli Zhang, Xiu-Jie Liu, Qingyu Wu, Rongfang Shi, Ronglin Gao, Yunzhong Liu, Shengshou Hu, Yueqin Tian, Shaoxian Guo and Wei Fang
Journal of Nuclear Medicine August 2001, 42 (8) 1166-1173;
Xiaoli Zhang
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Xiu-Jie Liu
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Qingyu Wu
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Rongfang Shi
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Ronglin Gao
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Yunzhong Liu
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Shengshou Hu
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Yueqin Tian
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Shaoxian Guo
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Wei Fang
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  • FIGURE 1.
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    FIGURE 1.

    99mTc-MIBI SPECT and FDG PET images of patient with MI. (A) Perfusion–metabolism MM at apex, anterior, septal, and inferoposterior walls (arrows) before revascularization. (B) After CABG, perfusion defects of segments improved significantly and size of left ventricle decreased. EF increased from 30% to 42%. ST = stress; RE = rest.

  • FIGURE 2.
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    FIGURE 2.

    99mTc-MIBI SPECT (A) and FDG PET (B) images of patient with MI show perfusion–metabolism M in inferoposterior wall (arrows) before revascularization. (C) After CABG, perfusion defects did not improve and EF did not change (38% vs. 39%).

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    FIGURE 3.

    Changes of EF (%) and EDD (mm) at baseline (Pre), 3 mo (Pos1), and 6 mo (Pos2) after revascularization in groups A1 and B1.

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    FIGURE 4.

    Cumulative cardiac event-free survival curves of groups A1 and A2 (A) and groups B1 and B2 (B). RVS = revascularization; Med = medical therapy.

  • FIGURE 5.
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    FIGURE 5.

    Cumulative survival curves of groups A1 and A2 (A) and groups B1 and B2 (B). RVS = revascularization; Med = medical therapy.

  • FIGURE 6.
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    FIGURE 6.

    Cumulative cardiac event-free survival curves of patients with aneurysm and viable myocardium (A) and patients with aneurysm and no viable myocardium (B). RVS = revascularization; Med = medical therapy.

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    TABLE 1

    Clinical and Angiographic Data

    VariableGroup
    A1 (n = 42)A2* (n = 30)B1 (n = 25)B2* (n = 26)
    Age (y)53 ± 1056 ± 956 ± 756 ± 9
    M/F39/328/223/224/2
    History (mo.)44 ± 4867 ± 5048 ± 5057 ± 65
    Smoking (%)21 (50)12 (40)12 (48)11 (42)
    Hypertension (%)21 (50)12 (40)12 (48)7 (27)
    Diabetes (%)8 (19)2 (7)3 (12)3 (12)
    Hyperlipidemia (%)7 (17)7 (23)7 (28)5 (19)
    Family history of CAD (%)7 (17)6 (20)7 (28)5 (19)
    Previous MI
     Q-wave MI (%)33 (79)23 (77)19 (76)20 (77)
     Anterior MI (%)28 (67)20 (67)19 (76)18 (69)
     Aneurysm (%)13 (31)9 (30)10 (40)9 (35)
     NYHA class† III–IV (%)20 (48)16 (53)14 (56)14 (54)
     CCS class‡ II–IV (%)37 (88)25 (83)22 (88)22 (85)
    EF (%)36 ± 535 ± 836 ± 634 ± 6
    EDD (mm)62 ± 861 ± 760 ± 461 ± 6
    Coronary angiography
     IVD (%)5 (12)4 (13)3 (12)2 (8)
     MVD (%)37 (88)26 (87)22 (88)24 (92)
    • ↵* P > 0.05 (group A1 vs. group A2, group B1 vs. group B2).

    • ↵† NYHA heart failure class.

    • ↵‡ CCS angina class.

    • IVD = single-vessel disease; MVD = multiple-vessel disease.

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    TABLE 2

    Independent Predictors of Cardiac Event and Cardiac Mortality by Cox Multivariate Analysis

    Variableχ2Relative risk95% CIP
    Cardiac event
     Revascularization29.50.050.01–0.18<0.0000
     CCS class*10.22.271.27–4.03<0.005
     No. of MM segments4.041.41.00–1.95<0.05
     NYHA class†3.931.901.03–3.47<0.05
    Cardiac mortality
     Revascularization8.580.130.03–0.64<0.01
     NYHA class†8.723.271.46–7.29<0.001
    • ↵* CCS angina class.

    • ↵† NYHA heart failure class.

    • CI = confidence interval.

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Journal of Nuclear Medicine: 42 (8)
Journal of Nuclear Medicine
Vol. 42, Issue 8
August 1, 2001
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Clinical Outcome of Patients with Previous Myocardial Infarction and Left Ventricular Dysfunction Assessed with Myocardial 99mTc-MIBI SPECT and 18F-FDG PET
Xiaoli Zhang, Xiu-Jie Liu, Qingyu Wu, Rongfang Shi, Ronglin Gao, Yunzhong Liu, Shengshou Hu, Yueqin Tian, Shaoxian Guo, Wei Fang
Journal of Nuclear Medicine Aug 2001, 42 (8) 1166-1173;

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Clinical Outcome of Patients with Previous Myocardial Infarction and Left Ventricular Dysfunction Assessed with Myocardial 99mTc-MIBI SPECT and 18F-FDG PET
Xiaoli Zhang, Xiu-Jie Liu, Qingyu Wu, Rongfang Shi, Ronglin Gao, Yunzhong Liu, Shengshou Hu, Yueqin Tian, Shaoxian Guo, Wei Fang
Journal of Nuclear Medicine Aug 2001, 42 (8) 1166-1173;
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  • Increasing Benefit From Revascularization Is Associated With Increasing Amounts of Myocardial Hibernation: A Substudy of the PARR-2 Trial
  • Long-Term Survival of Patients with Viable and Nonviable Aneurysms Assessed by 99mTc-MIBI SPECT and 18F-FDG PET: A Comparative Study of Medical and Surgical Treatment
  • Stunning, Hibernation, and Assessment of Myocardial Viability
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  • Comparison of Microsphere-Equivalent Blood Flow (15O-Water PET) and Relative Perfusion (99mTc-Tetrofosmin SPECT) in Myocardium Showing Metabolism-Perfusion Mismatch
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