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Journal of Nuclear Medicine

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OtherBASIC SCIENCE INVESTIGATIONS

Quantification of Regional Myocardial Blood Flow Using Dynamic H215O PET and Factor Analysis

Ji Young Ahn, Dong Soo Lee, Jae Sung Lee, Seok-Ki Kim, Gi Jeong Cheon, Jeong Seok Yeo, Seung-Ai Shin, June-Key Chung and Myung Chul Lee
Journal of Nuclear Medicine May 2001, 42 (5) 782-787;
Ji Young Ahn
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Dong Soo Lee
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Jae Sung Lee
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Seok-Ki Kim
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Gi Jeong Cheon
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Jeong Seok Yeo
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Seung-Ai Shin
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June-Key Chung
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Myung Chul Lee
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  • FIGURE 1.
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    FIGURE 1.

    Schematic representation of processing steps of factor analysis to yield input function and regional myocardial TACs. LV = left ventricle; RV = right ventricle.

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    FIGURE 2.

    Right ventricular (RV) (A), left ventricular (LV) (B), and myocardial (C) factor images obtained from first step of factor analysis. All dynamic H215O PET studies gave consistent results.

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    FIGURE 3.

    Input functions by factor analysis and arterial sampling. Blood samples were drawn from radial arteries.

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    FIGURE 4.

    Representative TACs of left ventricle and myocardium. Curves were obtained by factor analysis (A) and ROI method (B).

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    FIGURE 5.

    Correlations between rMBF by factor analysis and rMBF by microsphere studies (r = 0.95; y = 0.95x + 0.26) (A) and between rMBF by ROI method and rMBF by microsphere studies (r = 0.93; y = 0.88x − 0.01) (B).

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    TABLE 1

    Differences in rMBFs Obtained by Factor Analysis, ROI Method, and Microsphere Studies

    MethodSeptalLateralInferiorAnterior
    Factor analysis*−0.07 ± 0.44−0.07 ± 0.55−0.25 ± 0.45−0.19 ± 0.43
    ROI method†0.14 ± 0.410.24 ± 0.440.24 ± 0.420.05 ± 0.45
    • ↵* Mean (±SD) difference between rMBF by microsphere studies and rMBF by factor analysis.

    • ↵† Mean (±SD) difference between rMBF by microsphere studies and rMBF by ROI method.

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Journal of Nuclear Medicine
Vol. 42, Issue 5
May 1, 2001
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Quantification of Regional Myocardial Blood Flow Using Dynamic H215O PET and Factor Analysis
Ji Young Ahn, Dong Soo Lee, Jae Sung Lee, Seok-Ki Kim, Gi Jeong Cheon, Jeong Seok Yeo, Seung-Ai Shin, June-Key Chung, Myung Chul Lee
Journal of Nuclear Medicine May 2001, 42 (5) 782-787;

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Quantification of Regional Myocardial Blood Flow Using Dynamic H215O PET and Factor Analysis
Ji Young Ahn, Dong Soo Lee, Jae Sung Lee, Seok-Ki Kim, Gi Jeong Cheon, Jeong Seok Yeo, Seung-Ai Shin, June-Key Chung, Myung Chul Lee
Journal of Nuclear Medicine May 2001, 42 (5) 782-787;
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  • Generation of Parametric Image of Regional Myocardial Blood Flow Using H215O Dynamic PET and a Linear Least-Squares Method
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