HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Figures Only Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Namdar, M. Articles by Kaufmann, P. A. Search for Related Content PubMed PubMed Citation Articles by Namdar, M. Articles by Kaufmann, P. A.

Integrated PET/CT for the Assessment of Coronary Artery Disease: A Feasibility Study

¹ Nuclear Cardiology Section, Division of Cardiology, University Hospital, Zurich, Switzerland
² Division of Nuclear Medicine, University Hospital, Zurich, Switzerland

	ABSTRACT

TOP ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION CONCLUSION REFERENCES

 
An accurate, noninvasive technique for the diagnosis of coronary artery disease (CAD) should provide complementary information on coronary anatomy and pathophysiologic lesion severity. We present, what is to our knowledge, the first clinical evaluation of integrated PET/CT for combined acquisition of coronary anatomy and perfusion. Methods: On an integrated PET/CT scanner, contrast-enhanced CT angiography (CTA) and rest/adenosine-stress myocardial perfusion scanning with ¹³N-ammonia were performed on 25 patients with CAD documented by coronary angiography. Contrast-enhanced CTA was performed with retrospective electrocardiography gating after injection of 150 mL of intravenous contrast medium. Decisions on whether to treat with revascularization (anatomic lesion plus ischemia) or conservatively (no lesion or no ischemia) based on PET/CT were compared with those based on PET plus coronary angiography. Results: Of the 100 coronary artery segments (left main, left anterior descending, left circumflex, and right in 25 patients), 7 (in 5 patients) were considered impossible to evaluate by CT because of rapid vessel movement but were correctly categorized by PET alone. In the remaining 93 segments, the sensitivity and specificity of PET/CT versus PET plus coronary angiography were 90% and 98%, respectively. Positive and negative predictive values were 82% and 99%, and accuracy was 97%. Conclusion: The data of this preliminary study suggest that PET/CT allows accurate noninvasive clinical decision making about CAD. Because of its high negative predictive value, PET/CT may play an important role in noninvasive selection of CAD patients for revascularization. Integration of higher-performance multislice spiral CT scanners into PET/CT hybrids will accelerate the clinical implementation of this technique.

Key Words: hybrid PET/CT • coronary angiography • coronary artery disease • PET • CT

	INTRODUCTION

TOP ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION CONCLUSION REFERENCES

 
Coronary angiography is at present the only accepted method for clinical imaging of coronary artery disease (CAD). Despite its cost, inconvenience to patients, and a small but distinct procedure-related morbidity (1.5%) and mortality (0.2%) rate, more than 1 million invasive diagnostic coronary angiography procedures are performed per year in the United States alone. Although coronary angiography is the standard imaging method, it is far from being perfect. Its accuracy is severely hampered by a significant intraobserver and interobserver variability in defining the anatomic relevance of stenoses (up to 50%) (1,2) as underlined by a poor correlation with postmortem coronary anatomy (3,4). In addition, angiographic findings are not able to predict the physiologic relevance of a coronary stenosis (2,5–8). Therefore, it has become clinical standard to require proof of ischemia by a noninvasive test before considering revascularization procedures (9,10).

Because between 20% and 40% of all diagnostic invasive coronary angiograms reveal clinically insignificant disease (11), noninvasive procedures have the potential to play an important role in avoiding unnecessary coronary angiography. Several strategies have been suggested for noninvasive coronary imaging, such as dichromatic synchrotron radiation (12), electron beam tomography (13), MRI (14,15), and multislice spiral CT (1–5,9,10,16).

We hypothesized that assessment of CAD with the combination of PET and contrast-enhanced CTA would noninvasively provide comprehensive information that allows accurate decisions on whether to treat with revascularization or conservatively.

	MATERIALS AND METHODS

TOP ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION CONCLUSION REFERENCES

 
Study Population
Twenty-five consecutive patients (mean age, 62 y; range, 39–78 y; 22 men and 3 women) who had a history of CAD and underwent elective coronary angiography for recurrent chest pain were invited to participate in the study. A history of myocardial infarction, bypass graft surgery, or previous successful angioplasty was found in 13, 6, and 5 patients, respectively. A coronary artery stenosis was defined as relevant if a diameter reduction of up to 50% was documented by x-ray coronary angiography. Triple-vessel disease was found in 7, dual-vessel disease in 6, and single-vessel disease in 12 patients. All patients had sinus rhythm (mean heart rate, 68 beats per minute; range, 51–83 beats per minute) and were clinically stable. The interval between the coronary angiography and the PET/CT scan was less than 4 wk. Exclusion criteria were severe heart failure (left ventricular ejection fraction < 30%) and renal failure (serum creatinine level > 1.2 mg/dL). All patients had been referred for clinical reasons for a PET perfusion scan. Written informed consent for an additional CT scan was obtained from all patients before the study, which had been approved by the local ethics committee.

PET/CT Scanning
Images were acquired on a Discovery LS PET/CT scanner (GE Healthcare), an integration of an Advance NXi PET scanner with a LightSpeed Plus 4-row helical CT scanner.

The field of view for the multislice spiral CT angiographic study was localized by a scout scan from the carina to 1 cm below the inferoposterior wall of the heart. Afterward, a bolus of 15 mL of iopentol contrast agent (Imagopaque 300; Amersham Health) was injected intravenously and antecubitally at a speed of 3.5 mL/s, and after a delay of 10 s a sequence of 12 axial images was acquired. The interval between injection and peak enhancement in the aortic root was determined as transit time. All patients underwent contrast-enhanced CTA with 150 mL of contrast medium (3.5 mL/s) and simultaneous acquisition of 4 parallel slices. Images were acquired during a breath-hold after inspiration, and electrocardiography was recorded continuously.

This study was followed by a myocardial perfusion PET scan without moving the patient. All subjects received 700–900 MBq of ¹³N-ammonia into a peripheral vein by bolus injection while acquisition of the serial (9 x 10-s, 6 x 15-s, 3 x 20-s, 2 x 30-s, and 1 x 900-s frames) transaxial tomographic images of the heart was started and followed by a CT transmission scan for photon attenuation correction (17). After allowing for decay of the ¹³N, perfusion scanning was repeated during a standard infusion of intravenous adenosine at a rate of 0.14 mg/kg/min.

CT Image Reconstruction
CT raw data were reconstructed using a conventional multislice spiral CT algorithm. Cross-sectional images were then reconstructed at 1-mm intervals. Spiral data were collected from successive heartbeats by applying a filter function not only in the z direction (along the patients’ longitudinal axis) but also in the heart phase, using routine filtered backprojection for CT and applying retrospective electrocardiography gating. Several image sets were analyzed by moving the center of image acquisition from 60% toward the end of the cardiac cycle in increments of 10%. For each coronary artery, the dataset containing the fewest motion artifacts was chosen for further evaluation.

Image Fusion
The CT images were segmented on an image-by-image basis to eliminate all structures that would obstruct the view of the coronary arteries (i.e., chest wall, pulmonary vessels, and atrial appendages). Three-dimensional reconstructions of the multislice spiral CT scans were performed using the Advantage Windows software package (version 4.1; GE Healthcare), providing the coronary artery tree and the shape of the heart. Onto the myocardial surface as visualized by CT, the color-coded qualitative perfusion images obtained by PET were superimposed (Fig. 1). The images of the last 900-s frame were used to assess ischemia. A reversible defect during adenosine infusion, disappearing at rest, was considered to represent ischemia (Fig. 2).

View larger version (65K): [in this window] [in a new window]   FIGURE 1. Three-dimensional reconstruction of multislice spiral CT scan showing coronary artery tree and shape of heart, superimposed by color-coded qualitative stress perfusion image obtained by PET. Ammonia has been used as perfusion tracer; red indicates normal stress perfusion response in anterior and lateral segments of left ventricle.

View larger version (48K): [in this window] [in a new window]   FIGURE 2. (A) Contrast-enhanced CT angiogram showing stenotic lesion in left circumflex coronary artery with faint poststenotic flow (arrow). (B) Coronary angiogram showing same stenotic lesion (arrow). (C) Combined 3-dimensional reconstruction of multislice spiral CT scan showing coronary artery tree and shape of heart, superimposed by color-coded qualitative stress perfusion image obtained by PET. Blue indicates reversible perfusion defect (i.e., ischemia). Lesion described in A and B is hemodynamically relevant, as documented by reduced hyperemic response to adenosine stress in lateral wall (arrowheads).

Combined information on anatomy (coronary angiography or contrast-enhanced CTA) and perfusion (PET) was used in making decisions about revascularization or conservative treatment (Fig. 3). According to the respective guidelines (9,10), only the combination of significant stenosis plus evidence of ischemia (by PET) led the decision toward revascularization, whereas the combination of no stenosis plus no ischemia or stenosis without ischemia led the decision toward conservative treatment (Fig. 4). The results of the combined evaluation by PET plus coronary angiography served as the gold standard against which the combined evaluation by PET/CT was validated (Fig. 5).

View larger version (11K): [in this window] [in a new window]   FIGURE 3. Overview of morphologic findings (angiography and CT) and functional findings (PET). For all territories subtended by normal or stenotic coronary vessels, categoric information on ischemia as assessed by PET is given.

View larger version (13K): [in this window] [in a new window]   FIGURE 4. Diagnostic algorithm for clinical decision making. Only the combination of angiographically significant stenosis and evidence of ischemia (by PET) led the decision toward revascularization. Angio = angiography.

View larger version (11K): [in this window] [in a new window]   FIGURE 5. Clinical decision making according to findings of PET plus angiography (Angio) represents gold standard. Decisions made according to PET/CT findings were compared with gold standard. NPV = negative predictive value; PPV = positive predictive value.

	RESULTS

TOP ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION CONCLUSION REFERENCES

Contrast-Enhanced CTA Versus Coronary Angiography
Of the 100 coronary arteries (left main, left anterior descending, left circumflex, and right in 25 patients) and 12 bypass grafts, 7 segments (in 5 patients) were considered impossible to evaluate because of blurring (rapid vessel movement). The respective coronary artery territories, however, could successfully be evaluated using PET data.

After the 7% of segments that were not assessable by CT (left anterior descending, 4 times; left circumflex, 3 times) had been excluded from the primary analysis, contrast-enhanced CTA alone correctly detected the 1 substantial lesion of the left main coronary artery, 12 of the 14 lesions of the left anterior descending coronary artery, 7 of the 7 lesions of the left circumflex coronary artery, 7 of the 8 lesions of the right coronary artery, and the 1 bypass graft occlusion (sensitivity, 90%).

In the arteries that could be evaluated by CT angiography, the absence of significant lesions was correctly determined in 20 of 24 left main coronary arteries, in 8 of 11 left anterior descending coronary arteries, in 9 of 15 left circumflex coronary arteries, in 11 of 13 right coronary arteries, and in 12 of 12 patent bypass grafts (specificity, 75%). Most of the false-positive findings by CT were caused (at least in part) by artifacts due to calcifications, which are likely to affect contrast-enhanced CTA (performed with a 4-slice CT scanner) in a population with an average age of 62 y.

Combined Results: PET/CT Versus PET Plus Coronary Angiography
In 10 of the 13 patients with a history of myocardial infarction, PET documented a resting defect, which was located in the territory of an occluded artery in 9 patients and in the territory of a vessel with a high-grade stenosis in 1 patient. CT revealed the lesion in all of these patients. Furthermore, the location of the stress-induced perfusion defects corresponded to the site of the coronary stenosis as identified by CT angiography. The 3-dimensional volume–rendered view appeared particularly helpful for correlating the location of the lesion with the corresponding defect (Fig. 2).

Interestingly, for 13 of 23 lesions documented by coronary angiography and contrast-enhanced CTA, PET revealed no ischemia, providing no indication for revascularization. In addition, contrast-enhanced CTA found 7 false-positive lesions, which, however, were correctly assigned to "no revascularization" when the PET information was added (Fig. 4). The combination of PET plus coronary angiography classified 11 lesions as requiring, and 89 as not requiring, revascularization according to the predefined gold standard (i.e., anatomic lesion plus ischemia). For PET/CT, these numbers were 11 (sensitivity, 90%) and 82 (specificity, 98%), respectively. Positive and negative predictive values were 82% and 99%, respectively, resulting in an accuracy of 97% (Fig. 5). Table 1 compares the contrast-enhanced CTA findings with the CT findings and stress perfusion defects. As summarized in Figure 4, 10 segments had ischemia subtended by a stenotic coronary artery. Four of these had a proximal coronary lesion and a large stress perfusion defect, whereas 6 had a distal lesion and a small perfusion defect. Thirteen segments had a stenotic lesion documented by invasive angiography but no corresponding ischemia. Most of these false-negative PET findings occurred in patients with multivessel disease, a fact that may have contributed to the false-negative findings.

	DISCUSSION

TOP ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION CONCLUSION REFERENCES

Previous studies either have concentrated on patients without coronary stenoses or have included a large share of patients without coronary stenoses (16,22). In view of this, the high negative predictive value despite the high pretest probability in our study population is particularly remarkable with regard to a potential future role of PET/CT as a screening test, that is, in an intermediate-pretest-probability population. In addition, all 7 false-positive lesions and the 7 coronaries that were not amenable to an evaluation by contrast-enhanced CTA because of motion artifacts were correctly classified after the PET information had been included. This synergistic effect further substantiates the great clinical benefit of integrated PET/CT. Contrast-enhanced CTA artifacts due to rapid coronary artery motion are a well-known shortcoming of multislice spiral CT (23–25) but can—at least in part—be outweighed by the information gained from the simultaneous PET scan.

The benefit of simultaneous noninvasive assessment of coronary anatomy and myocardial perfusion seems to lie in a substantially improved diagnostic confidence in deciding on the best therapeutic strategy. Elective interventional therapy can be planned carefully, contributing to avoid overuse of angioplasty and stent placement. This is extremely relevant, because overuse of expensive intravascular stents is a key driver of cost in invasive cardiology practice. When lesion anatomy appears unsuitable for angioplasty, bypass grafting can be considered directly without the need for further preoperative diagnostic coronary angiography, provided the contrast-enhanced CTA images are of adequate quality.

The present study had several shortcomings, which were mainly technical. The type of CT scanner used has been shown unable to produce consistently high-quality contrast-enhanced CTA images in most hands. However, the latest developments of multislice CT—faster gantry rotation speeds of 16 and more slices—will substantially improve image quality, specifically at higher heart rates (26). In addition, technical innovations will allow reduction of the radiation dose. The radiation dose of a CT scan has been extensively studied and was recently confirmed to be about 7 mSv by Nieman et al. (26). We did not measure the radiation dose in our imaging protocol, but as the scans are additive, one can readily calculate the total dose to be 7 mSv (contrast-enhanced CTA) + 2 x 1 mSv (PET scan) + 0.3 mSv (CT transmission scan) = 10–12 mSv, which is comparable to values found with invasive coronary angiography (3–10 mSv) (27). This radiation dose is still acceptable, considering the fact that many serial CT scans may have radiation doses as high as 20–30 mSv.

The relatively long breath-hold required constitutes another limitation. Because all our patients were receiving long-term ß-receptor antagonist treatment, heart rate was relatively low, although medication was withheld for the day of the study and we did not administer ß-receptor antagonists for heart rate control because of the possible effect on the adenosine-stress perfusion PET scan.

A major limitation of the present study was the small number of patients included. The patients were few because the study was designed to assess the feasibility of combined PET/CT, rather than its impact on clinical decision making.

	CONCLUSION

TOP ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION CONCLUSION REFERENCES

 
Combination of myocardial perfusion PET and multislice spiral contrast-enhanced CTA is a feasible and interesting approach for noninvasive complementary evaluation of morphologic and functional CAD. Besides being a noninvasive alternative, the PET/CT technique adds functional information on the pathophysiologic impact of a lesion, allowing accurate clinical decision making on the best therapeutic strategy. Certainly, the present findings must be considered preliminary in view of the small number of patients in this initial study. Therefore, firm conclusions about a potential role for integrated cardiac PET/CT in clinical decision making cannot be drawn from our results but must await further confirmation in larger trials. The encouraging results of this investigation, however, seem to justify further efforts to improve the accuracy of PET/CT for the detection of CAD by implementing higher-performance multislice spiral CT scanners into PET/CT hybrids. Such technical refinements may accelerate the clinical implementation of PET/CT.

	ACKNOWLEDGMENTS

 
This study was funded by a grant from the Swiss National Science Foundation (SNSF-professorship grants PP00A-68835 and 31-68386), from GE Healthcare, and from Amersham Health, Medical Diagnostics Europe. Mehdi Namdar and Thomas F. Hany contributed equally to this study.

	FOOTNOTES

 
Received Sep. 3, 2004; revision accepted Feb. 26, 2005.

For correspondence or reprints contact: Philipp A. Kaufmann, MD, Nuclear Cardiology Section, Cardiovascular Center NUK C 32, University Hospital, Raemistrasse 100, CH-8091 Zurich, Switzerland.

E-mail: pak{at}usz.ch

	REFERENCES

TOP ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION CONCLUSION REFERENCES

 

1. Galbraith JE, Murphy ML, Desoyza N. Coronary angiogram interpretation: interobserver variability. JAMA. 1981;240:2053–2059.
2. White CW, Wright CB, Doty DB, et al. Does visual interpretation of the coronary arteriogram predict the physiologic importance of a coronary stenosis? N Engl J Med. 1984;310:819–824.[Abstract]
3. Vlodaver Z, Frech R, Van Tassel RA, Edwards JE. Correlation of the antemortem coronary arteriogram and the postmortem specimen. Circulation. 1973;47:162–169.[Abstract/Free Full Text]
4. Arnett EN, Isner JM, Redwood DR, et al. Coronary artery narrowing in coronary heart disease: comparison of cineangiographic and necropsy findings. Ann Intern Med. 1979;91:350–356.
5. Zijlstra F, van Ommeren J, Reiber JH, Serruys PW. Does the quantitative assessment of coronary artery dimensions predict the physiologic significance of a coronary stenosis? Circulation. 1987;75:1154–1161.[Abstract/Free Full Text]
6. Topol EJ, Nissen SE. Our preoccupation with coronary luminology: the dissociation between clinical and angiographic findings in ischemic heart disease. Circulation. 1995;92:2333–2342.[Abstract/Free Full Text]
7. Pijls NH, De BB, Peels K, et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med. 1996;334:1703–1708.[Abstract/Free Full Text]
8. Bech GJ, De Bruyne B, Bonnier HJ, et al. Long-term follow-up after deferral of percutaneous transluminal coronary angioplasty of intermediate stenosis on the basis of coronary pressure measurement. J Am Coll Cardiol. 1998;31:841–847.[Abstract/Free Full Text]
9. Smith SC Jr, Dove JT, Jacobs AK, et al. ACC/AHA guidelines of percutaneous coronary interventions (revision of the 1993 PTCA guidelines): executive summary—a report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty). J Am Coll Cardiol. 2001;37:2215–2239.[Free Full Text]
10. Klocke FJ, Baird MG, Lorell BH, et al. ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging: executive summary—a report of the American College of Cardiology/American Heart Association task force on practice guidelines (ACC/AHA/ASNC committee to revise the 1995 guidelines for the clinical use of cardiac radionuclide imaging). Circulation. 2003;108:1404–1418.[Free Full Text]
11. Achenbach S, Daniel WG. Noninvasive coronary angiography: an acceptable alternative? N Engl J Med. 2001;345:1909–1910.[Free Full Text]
12. Dill T, Job H, Dix WR, et al. Intravenous coronary angiography with synchrotron radiation [in German]. Z Kardiol. 2000;89.(suppl):27–33.
13. Achenbach S, Moshage W, Ropers D, Nossen J, Daniel WG. Value of electron-beam computed tomography for the noninvasive detection of high-grade coronary-artery stenoses and occlusions. N Engl J Med. 1998;339:1964–1971.[Abstract/Free Full Text]
14. Manning WJ, Li W, Edelman RR. A preliminary report comparing magnetic resonance coronary angiography with conventional angiography. N Engl J Med. 1993;328:828–832.[Abstract/Free Full Text]
15. Kim WY, Danias PG, Stuber M, et al. Coronary magnetic resonance angiography for the detection of coronary stenoses. N Engl J Med. 2001;345:1863–1869.[Abstract/Free Full Text]
16. Nieman K, Oudkerk M, Rensing BJ, et al. Coronary angiography with multi-slice computed tomography. Lancet. 2001;357:599–603.[Medline]
17. Koepfli P, Hany TF, Wyss CA, et al. CT attenuation correction for myocardial perfusion quantification using a PET/CT hybrid scanner. J Nucl Med. 2004;45:537–542.[Abstract/Free Full Text]
18. Topol EJ, Califf RM, George BS, et al. A randomized trial of immediate versus delayed elective angioplasty after intravenous tissue plasminogen activator in acute myocardial infarction. N Engl J Med. 1987;317:581–588.[Abstract]
19. Ellis SG, Topol EJ, George BS, et al. Recurrent ischemia without warning: analysis of risk factors for in-hospital ischemic events following successful thrombolysis with intravenous tissue plasminogen activator. Circulation. 1989;80:1159–1165.[Abstract/Free Full Text]
20. The TIMI study group: comparison of invasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction—results of the thrombolysis in myocardial infarction (TIMI) phase II trial. N Engl J Med. 1989;320:618–627.[Abstract]
21. Reiner JS, Lundergan CF, van den Brand M, et al. Early angiography cannot predict postthrombolytic coronary reocclusion: observations from the GUSTO angiographic study—global utilization of streptokinase and t-PA for occluded coronary arteries. J Am Coll Cardiol. 1994;24:1439–1444.[Abstract]
22. Achenbach S, Ulzheimer S, Baum U, et al. Noninvasive coronary angiography by retrospectively ECG-gated multislice spiral CT. Circulation. 2000;102:2823–2828.[Abstract/Free Full Text]
23. Achenbach S, Giesler T, Ropers D, et al. Detection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography. Circulation. 2001;103:2535–2538.[Abstract/Free Full Text]
24. Nieman K, Rensing BJ, van Geuns RJ, et al. Usefulness of multislice computed tomography for detecting obstructive coronary artery disease. Am J Cardiol. 2002;89:913–918.[Medline]
25. Rumberger JA. Noninvasive coronary angiography using computed tomography: ready to kick it up another notch? Circulation. 2002;106:2036–2038.[Free Full Text]
26. Nieman K, Cademartiri F, Lemos PA, et al. Reliable noninvasive coronary angiography using fast sub-millimeter multislice spiral computed tomography. Circulation. 2002;106:2051–2054.[Abstract/Free Full Text]
27. Morin RL, Gerber TC, McCollough CH. Radiation dose in computed tomography of the heart. Circulation. 2003;107:917–922.[Free Full Text]

This article has been cited by other articles:

				H Kuehl, H Eggebrecht, T Boes, G Antoch, S Rosenbaum, S Ladd, A Bockisch, J Barkhausen, and R Erbel Detection of inflammation in patients with acute aortic syndrome: comparison of FDG-PET/CT imaging and serological markers of inflammation Heart, November 1, 2008; 94(11): 1472 - 1477. [Abstract] [Full Text] [PDF]

				A. K. Buck, S. Nekolla, S. Ziegler, A. Beer, B. J. Krause, K. Herrmann, K. Scheidhauer, H.-J. Wester, E. J. Rummeny, M. Schwaiger, et al. SPECT/CT J. Nucl. Med., August 1, 2008; 49(8): 1305 - 1319. [Abstract] [Full Text] [PDF]

				S. Schroeder, S. Achenbach, F. Bengel, C. Burgstahler, F. Cademartiri, P. de Feyter, R. George, P. Kaufmann, A. F. Kopp, J. Knuuti, et al. Cardiac computed tomography: indications, applications, limitations, and training requirements: Report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology Eur. Heart J., February 2, 2008; 29(4): 531 - 556. [Abstract] [Full Text] [PDF]

				L. Husmann, I. Valenta, O. Gaemperli, O. Adda, V. Treyer, C. A. Wyss, P. Veit-Haibach, F. Tatsugami, G. K. von Schulthess, and P. A. Kaufmann Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating Eur. Heart J., January 2, 2008; 29(2): 191 - 197. [Abstract] [Full Text] [PDF]

				M. Dewey, B. Hamm, H-P. Dubel, and W. Rutsch Multislice computed tomography coronary angiography for triaging patients with positive radionuclide myocardial perfusion imaging QJM, January 1, 2008; 101(1): 65 - 67. [Full Text] [PDF]

				G. T. Wilson, P. Gopalakrishnan, and T. Tak Noninvasive Cardiac Imaging with Computed Tomography Clin. Med. Res., October 1, 2007; 5(3): 165 - 171. [Abstract] [Full Text] [PDF]

				M. Coceani and A. L'Abbate Role of delayed enhancement MRI in patients with acute coronary syndrome and unobstructed coronary arteries Eur. Heart J., October 1, 2007; 28(19): 2416 - 2417. [Full Text] [PDF]

				O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann Cardiac Image Fusion from Stand-Alone SPECT and CT: Clinical Experience J. Nucl. Med., May 1, 2007; 48(5): 696 - 703. [Abstract] [Full Text] [PDF]

				W. Wijns Anatomic-Functional Imaging by Single-Photon Emission Computed Tomography/Computed Tomography as the Cornerstone of Diagnosis and Treatment for Coronary Patients: A Glimpse Into the (Near) Future? J. Am. Coll. Cardiol., March 13, 2007; 49(10): 1068 - 1070. [Full Text] [PDF]

				S. Rispler, Z. Keidar, E. Ghersin, A. Roguin, A. Soil, R. Dragu, D. Litmanovich, A. Frenkel, D. Aronson, A. Engel, et al. Integrated Single-Photon Emission Computed Tomography and Computed Tomography Coronary Angiography for the Assessment of Hemodynamically Significant Coronary Artery Lesions J. Am. Coll. Cardiol., March 13, 2007; 49(10): 1059 - 1067. [Abstract] [Full Text] [PDF]

				J J Bax, R S Beanlands, F J Klocke, J Knuuti, A A Lammertsma, M A Schaefers, H R Schelbert, G K Von Schulthess, L J Shaw, G Z Yang, et al. Diagnostic and clinical perspectives of fusion imaging in cardiology: is the total greater than the sum of its parts? Heart, January 1, 2007; 93(1): 16 - 22. [Abstract] [Full Text] [PDF]

				B. Wagner, M. Anton, S. G. Nekolla, S. Reder, J. Henke, S. Seidl, R. Hegenloh, M. Miyagawa, R. Haubner, M. Schwaiger, et al. Noninvasive Characterization of Myocardial Molecular Interventions by Integrated Positron Emission Tomography and Computed Tomography J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2107 - 2115. [Abstract] [Full Text] [PDF]

				T. Schepis, O. Gaemperli, P. Koepfli, I. Valenta, K. Strobel, A. Brunner, S. Leschka, L. Desbiolles, L. Husmann, H. Alkadhi, et al. Comparison of 64-Slice CT with Gated SPECT for Evaluation of Left Ventricular Function J. Nucl. Med., August 1, 2006; 47(8): 1288 - 1294. [Abstract] [Full Text] [PDF]

				G. K. von Schulthess, H. C. Steinert, and T. F. Hany Integrated PET/CT: Current Applications and Future Directions Radiology, February 1, 2006; 238(2): 405 - 422. [Abstract] [Full Text] [PDF]

				O. Rimoldi, K. P. Schafers, R. Boellaard, F. Turkheimer, L. Stegger, M. P. Law, A. A. Lammerstma, and P. G. Camici Quantification of Subendocardial and Subepicardial Blood Flow Using 15O-Labeled Water and PET: Experimental Validation J. Nucl. Med., January 1, 2006; 47(1): 163 - 172. [Abstract] [Full Text] [PDF]

				T. R. DeGrado, M. T. Kitapci, S. Wang, J. Ying, and G. D. Lopaschuk Validation of 18F-Fluoro-4-Thia-Palmitate as a PET Probe for Myocardial Fatty Acid Oxidation: Effects of Hypoxia and Composition of Exogenous Fatty Acids J. Nucl. Med., January 1, 2006; 47(1): 173 - 181. [Abstract] [Full Text] [PDF]

				M. Schwaiger, S. Ziegler, and S. G. Nekolla PET/CT: Challenge for Nuclear Cardiology J. Nucl. Med., October 1, 2005; 46(10): 1664 - 1678. [Abstract] [Full Text] [PDF]

				W. Wijns The Diagnosis of Coronary Artery Disease: In Search of a "One-Stop Shop"? J. Nucl. Med., June 1, 2005; 46(6): 904 - 905. [Full Text] [PDF]

This Article Abstract Figures Only Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Namdar, M. Articles by Kaufmann, P. A. Search for Related Content PubMed PubMed Citation Articles by Namdar, M. Articles by Kaufmann, P. A.