Research ArticleBasic Science Investigation
Designed Ankyrin Repeat Protein–Mediated Peptide Nucleic Acid–Based Pretargeting: A Proof-of-Principle Study
Maryam Oroujeni, Kristina Westerlund, Eleftherios Papalanis, Alexander van Deventer, Yongsheng Liu, Jacob Clinton, Zhengyue Wang, Ivan Zelepukin, Anna Orlova, Vladimir Tolmachev and Amelie Eriksson Karlström
Journal of Nuclear Medicine May 2025, jnumed.125.269533; DOI: https://doi.org/10.2967/jnumed.125.269533
Maryam Oroujeni
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;
Kristina Westerlund
2Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden; and
Eleftherios Papalanis
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;
Alexander van Deventer
2Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden; and
Yongsheng Liu
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;
Jacob Clinton
2Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden; and
Zhengyue Wang
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;
Ivan Zelepukin
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;
Anna Orlova
3Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
Vladimir Tolmachev
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;
Amelie Eriksson Karlström
2Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden; and

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Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
Designed Ankyrin Repeat Protein–Mediated Peptide Nucleic Acid–Based Pretargeting: A Proof-of-Principle Study
Maryam Oroujeni, Kristina Westerlund, Eleftherios Papalanis, Alexander van Deventer, Yongsheng Liu, Jacob Clinton, Zhengyue Wang, Ivan Zelepukin, Anna Orlova, Vladimir Tolmachev, Amelie Eriksson Karlström
Journal of Nuclear Medicine May 2025, jnumed.125.269533; DOI: 10.2967/jnumed.125.269533
Designed Ankyrin Repeat Protein–Mediated Peptide Nucleic Acid–Based Pretargeting: A Proof-of-Principle Study
Maryam Oroujeni, Kristina Westerlund, Eleftherios Papalanis, Alexander van Deventer, Yongsheng Liu, Jacob Clinton, Zhengyue Wang, Ivan Zelepukin, Anna Orlova, Vladimir Tolmachev, Amelie Eriksson Karlström
Journal of Nuclear Medicine May 2025, jnumed.125.269533; DOI: 10.2967/jnumed.125.269533
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