In Vivo Visualization and Quantification of Brain Heat Shock Protein 90 with [11C]HSP990 in Healthy Aging and Neurodegeneration

Romy Cools; Koen Vermeulen; Eline Vonck; Veerle Baekelandt; Cassis Varlow; Valeria Narykina; Christopher Cawthorne; Koen Van Laere; Wim Vanduffel; Neil Vasdev; Guy Bormans

doi:10.2967/jnumed.124.268961

Article Information

jnumed.124.268961

DOI

https://doi.org/10.2967/jnumed.124.268961

PubMed

40306968

Published By

Society of Nuclear Medicine

Print ISSN

0161-5505

Online ISSN

2159-662X

History

Received for publication October 18, 2024
Accepted for publication March 24, 2025
Published online April 30, 2025.

© 2025 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: https://jnm.snmjournals.org/page/permissions.

Author Information

Romy Cools¹,
Koen Vermeulen²,
Eline Vonck³,
Veerle Baekelandt³,
Cassis Varlow⁴,
Valeria Narykina⁵,
Christopher Cawthorne⁶,
Koen Van Laere⁶,
Wim Vanduffel⁷,
Neil Vasdev⁴ and
Guy Bormans¹

¹Laboratory for Radiopharmaceutical Research, Department of Pharmacy and Pharmacologic Sciences, KU Leuven, Leuven, Belgium;
²Nuclear Medical Applications Institute, Belgian Nuclear Research Centre, Mol, Belgium;
³Laboratory for Neurobiology and Gene Therapy, Leuven Brain Institute, KU Leuven, Leuven, Belgium;
⁴Brain Health Imaging Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Canada;
⁵Switch Laboratory, Department of Cellular and Molecular Medicine, VIB-KU Leuven, Leuven, Belgium;
⁶Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium; and
⁷Laboratory for Neuro- and Psychophysiology, Department of Neuroscience, KU Leuven, Leuven, Belgium