Multicycle Dosimetric Behavior and Dose–Effect Relationships in [177Lu]Lu-DOTATATE Peptide Receptor Radionuclide Therapy

Gunjan Kayal; Molly E. Roseland; Chang Wang; Kellen Fitzpatrick; David Mirando; Krithika Suresh; Ka Kit Wong; Yuni K. Dewaraja

doi:10.2967/jnumed.124.269389

Research ArticleClinical Investigation

Multicycle Dosimetric Behavior and Dose–Effect Relationships in [¹⁷⁷Lu]Lu-DOTATATE Peptide Receptor Radionuclide Therapy

Gunjan Kayal, Molly E. Roseland, Chang Wang, Kellen Fitzpatrick, David Mirando, Krithika Suresh, Ka Kit Wong and Yuni K. Dewaraja

Journal of Nuclear Medicine April 2025, jnumed.124.269389; DOI: https://doi.org/10.2967/jnumed.124.269389

Gunjan Kayal

1Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan;

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Molly E. Roseland

1Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan;

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Chang Wang

2Departments of Biostatistics and Radiation Oncology, University of Michigan, Ann Arbor, Michigan; and

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Kellen Fitzpatrick

1Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan;

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David Mirando

3MIM Software, GE HealthCare, Cleveland, Ohio

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Krithika Suresh

2Departments of Biostatistics and Radiation Oncology, University of Michigan, Ann Arbor, Michigan; and

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Ka Kit Wong

1Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan;

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Yuni K. Dewaraja

1Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan;

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jnumed.124.269389

DOI

https://doi.org/10.2967/jnumed.124.269389

PubMed

40274371

Published By

Society of Nuclear Medicine

Print ISSN

0161-5505

Online ISSN

2159-662X

History

Received for publication December 18, 2024
Accepted for publication March 12, 2025
Published online April 24, 2025.

Author Information

Gunjan Kayal¹,
Molly E. Roseland¹,
Chang Wang²,
Kellen Fitzpatrick¹,
David Mirando³,
Krithika Suresh²,
Ka Kit Wong¹ and
Yuni K. Dewaraja¹

¹Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan;
²Departments of Biostatistics and Radiation Oncology, University of Michigan, Ann Arbor, Michigan; and
³MIM Software, GE HealthCare, Cleveland, Ohio

For correspondence or reprints, contact Yuni Dewaraja (yuni{at}umich.edu).

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Multicycle Dosimetric Behavior and Dose–Effect Relationships in [¹⁷⁷Lu]Lu-DOTATATE Peptide Receptor Radionuclide Therapy

Gunjan Kayal, Molly E. Roseland, Chang Wang, Kellen Fitzpatrick, David Mirando, Krithika Suresh, Ka Kit Wong, Yuni K. Dewaraja

Journal of Nuclear Medicine Apr 2025, jnumed.124.269389; DOI: 10.2967/jnumed.124.269389

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Multicycle Dosimetric Behavior and Dose–Effect Relationships in [¹⁷⁷Lu]Lu-DOTATATE Peptide Receptor Radionuclide Therapy

Gunjan Kayal, Molly E. Roseland, Chang Wang, Kellen Fitzpatrick, David Mirando, Krithika Suresh, Ka Kit Wong, Yuni K. Dewaraja

Journal of Nuclear Medicine Apr 2025, jnumed.124.269389; DOI: 10.2967/jnumed.124.269389

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Keywords

177Lu-DOTATATE
dosimetry
radiopharmaceutical therapy
theranostics
dose toxicity

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Multicycle Dosimetric Behavior and Dose–Effect Relationships in [¹⁷⁷Lu]Lu-DOTATATE Peptide Receptor Radionuclide Therapy

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