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Research ArticleSpecial Contribution

Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories

Tahir Yusufaly, Emilie Roncali, Julia Brosch-Lenz, Carlos Uribe, Abhinav K. Jha, Geoffrey Currie, Joyita Dutta, Georges El-Fakhri, Helena McMeekin, Neeta Pandit-Taskar, Jazmin Schwartz, Kuangyu Shi, Lidia Strigari, Habib Zaidi, Babak Saboury and Arman Rahmim
Journal of Nuclear Medicine February 2025, jnumed.124.267927; DOI: https://doi.org/10.2967/jnumed.124.267927
Tahir Yusufaly
1Division of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland;
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Emilie Roncali
2Department of Biomedical Engineering, University of California Davis, Davis, California;
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Julia Brosch-Lenz
3Institute of Nuclear Medicine, Glen Burnie, Maryland;
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Carlos Uribe
4Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada;
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Abhinav K. Jha
5Department of Biomedical Engineering and Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri;
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Geoffrey Currie
6School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia;
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Joyita Dutta
7Department of Biomedical Engineering, University of Massachusetts, Amherst, Massachusetts;
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Georges El-Fakhri
8Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut;
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Helena McMeekin
9Hermes Medical Solutions, London, United Kingdom;
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Neeta Pandit-Taskar
10Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
11Department of Radiology, Weill Cornell Medical College, New York, New York;
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Jazmin Schwartz
12Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York;
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Kuangyu Shi
13Department of Nuclear Medicine, University of Bern, Bern, Switzerland;
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Lidia Strigari
14Department of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy;
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Habib Zaidi
15Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland;
16Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands;
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Babak Saboury
17United Theranostics, Bethesda, Maryland; and
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Arman Rahmim
4Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada;
18Department of Physics, University of British Columbia, Vancouver, British Columbia, Canada
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Article Information

jnumed.124.267927
DOI 
https://doi.org/10.2967/jnumed.124.267927
PubMed 
39947910

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication April 22, 2024
  • Accepted for publication January 27, 2025
  • Published online February 13, 2025.

Article Versions

  • You are currently viewing a previous version of this article (February 13, 2025 - 11:50).
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Copyright & Usage 
© 2025 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Tahir Yusufaly1,
  2. Emilie Roncali2,
  3. Julia Brosch-Lenz3,
  4. Carlos Uribe4,
  5. Abhinav K. Jha5,
  6. Geoffrey Currie6,
  7. Joyita Dutta7,
  8. Georges El-Fakhri8,
  9. Helena McMeekin9,
  10. Neeta Pandit-Taskar10,11,
  11. Jazmin Schwartz12,
  12. Kuangyu Shi13,
  13. Lidia Strigari14,
  14. Habib Zaidi15,16,
  15. Babak Saboury17 and
  16. Arman Rahmim4,18
  1. 1Division of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland;
  2. 2Department of Biomedical Engineering, University of California Davis, Davis, California;
  3. 3Institute of Nuclear Medicine, Glen Burnie, Maryland;
  4. 4Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada;
  5. 5Department of Biomedical Engineering and Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri;
  6. 6School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia;
  7. 7Department of Biomedical Engineering, University of Massachusetts, Amherst, Massachusetts;
  8. 8Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut;
  9. 9Hermes Medical Solutions, London, United Kingdom;
  10. 10Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
  11. 11Department of Radiology, Weill Cornell Medical College, New York, New York;
  12. 12Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York;
  13. 13Department of Nuclear Medicine, University of Bern, Bern, Switzerland;
  14. 14Department of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy;
  15. 15Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland;
  16. 16Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands;
  17. 17United Theranostics, Bethesda, Maryland; and
  18. 18Department of Physics, University of British Columbia, Vancouver, British Columbia, Canada
  1. For correspondence or reprints, contact Tahir Yusufaly (tyusufa2{at}jhmi.edu).
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories
Tahir Yusufaly, Emilie Roncali, Julia Brosch-Lenz, Carlos Uribe, Abhinav K. Jha, Geoffrey Currie, Joyita Dutta, Georges El-Fakhri, Helena McMeekin, Neeta Pandit-Taskar, Jazmin Schwartz, Kuangyu Shi, Lidia Strigari, Habib Zaidi, Babak Saboury, Arman Rahmim
Journal of Nuclear Medicine Feb 2025, jnumed.124.267927; DOI: 10.2967/jnumed.124.267927

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Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Current Tools, Techniques, and Uncharted Territories
Tahir Yusufaly, Emilie Roncali, Julia Brosch-Lenz, Carlos Uribe, Abhinav K. Jha, Geoffrey Currie, Joyita Dutta, Georges El-Fakhri, Helena McMeekin, Neeta Pandit-Taskar, Jazmin Schwartz, Kuangyu Shi, Lidia Strigari, Habib Zaidi, Babak Saboury, Arman Rahmim
Journal of Nuclear Medicine Feb 2025, jnumed.124.267927; DOI: 10.2967/jnumed.124.267927
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  • Article
    • Abstract
    • REPURPOSING PHYSIOLOGICALLY BASED PHARMACOKINETICS (PBPK) INTO PHYSIOLOGICALLY BASED RADIOPHARMACOKINETICS (PBRPK) FOR PERSONALIZED RPT DOSIMETRY
    • RECALIBRATING EBRT RADIOBIOLOGY FOR MULTISCALE RPT DOSIMETRY
    • FORWARD-LOOKING VISION: CNO AS A BASIS FOR CROSS-SPECIALTY DIGITAL TWINS
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  • Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins
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