Collagen Hybridizing Peptide–Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis

Azmi A. Ahmad; Mean Ghim; Gunjan Kukreja; Afarin Neishabouri; Zhengxing Zhang; Jie Li; Mani Salarian; Jakub Toczek; Kiran Gona; Keshvad Hedayatyanfard; Tian Morrison; Jiasheng Zhang; Yiyun Henry Huang; Chi Liu; S. Michael Yu; Mehran M. Sadeghi

doi:10.2967/jnumed.124.268832

Research ArticleBasic Science Investigation

Collagen Hybridizing Peptide–Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis

Azmi A. Ahmad, Mean Ghim, Gunjan Kukreja, Afarin Neishabouri, Zhengxing Zhang, Jie Li, Mani Salarian, Jakub Toczek, Kiran Gona, Keshvad Hedayatyanfard, Tian Morrison, Jiasheng Zhang, Yiyun Henry Huang, Chi Liu, S. Michael Yu and Mehran M. Sadeghi

Journal of Nuclear Medicine February 2025, jnumed.124.268832; DOI: https://doi.org/10.2967/jnumed.124.268832

Azmi A. Ahmad

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Mean Ghim

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Gunjan Kukreja

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Afarin Neishabouri

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Zhengxing Zhang

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Jie Li

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

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Mani Salarian

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Jakub Toczek

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Kiran Gona

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Keshvad Hedayatyanfard

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Tian Morrison

3Department of Biomedical Engineering and Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, Utah; and

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Jiasheng Zhang

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Yiyun Henry Huang

4Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut

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Chi Liu

4Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut

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S. Michael Yu

3Department of Biomedical Engineering and Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, Utah; and

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Mehran M. Sadeghi

1Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;

2Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut;

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Journal of Nuclear Medicine

Vol. 66, Issue 5

May 1, 2025

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Collagen Hybridizing Peptide–Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis

Journal of Nuclear Medicine Feb 2025, jnumed.124.268832; DOI: 10.2967/jnumed.124.268832

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Collagen Hybridizing Peptide–Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis

Journal of Nuclear Medicine Feb 2025, jnumed.124.268832; DOI: 10.2967/jnumed.124.268832

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Keywords

Molecular imaging
pulmonary fibrosis
collagen
SPECT/CT

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