Research ArticleBasic Science Investigation
Identification of (R)-[18F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development
Yingfang He, Stefanie D. Krämer, Uwe Grether, Matthias B. Wittwer, Ludovic Collin, Bernd Kuhn, Andreas Topp, Dominik Heer, Fionn O’Hara, Michael Honer, Anto Pavlovic, Hans Richter, Martin Ritter, Didier Rombach, Claudia Keller, Luca Gobbi and Linjing Mu
Journal of Nuclear Medicine December 2023, jnumed.123.266426; DOI: https://doi.org/10.2967/jnumed.123.266426
Yingfang He
1Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland; and
Stefanie D. Krämer
1Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland; and
Uwe Grether
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Matthias B. Wittwer
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Ludovic Collin
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Bernd Kuhn
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Andreas Topp
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Dominik Heer
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Fionn O’Hara
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Michael Honer
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Anto Pavlovic
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Hans Richter
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Martin Ritter
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Didier Rombach
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Claudia Keller
1Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland; and
Luca Gobbi
2Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland
Linjing Mu
1Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland; and

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In this issue
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
Identification of (R)-[18F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development
Yingfang He, Stefanie D. Krämer, Uwe Grether, Matthias B. Wittwer, Ludovic Collin, Bernd Kuhn, Andreas Topp, Dominik Heer, Fionn O’Hara, Michael Honer, Anto Pavlovic, Hans Richter, Martin Ritter, Didier Rombach, Claudia Keller, Luca Gobbi, Linjing Mu
Journal of Nuclear Medicine Dec 2023, jnumed.123.266426; DOI: 10.2967/jnumed.123.266426
Identification of (R)-[18F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development
Yingfang He, Stefanie D. Krämer, Uwe Grether, Matthias B. Wittwer, Ludovic Collin, Bernd Kuhn, Andreas Topp, Dominik Heer, Fionn O’Hara, Michael Honer, Anto Pavlovic, Hans Richter, Martin Ritter, Didier Rombach, Claudia Keller, Luca Gobbi, Linjing Mu
Journal of Nuclear Medicine Dec 2023, jnumed.123.266426; DOI: 10.2967/jnumed.123.266426
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