Research ArticleFocus on Molecular Imaging

Imaging Agents for PET of Inflammatory Bowel Disease: A Review

Farzaneh Rezazadeh, Aidan P. Kilcline and Nerissa T. Viola
Journal of Nuclear Medicine November 2023, jnumed.123.265935; DOI: https://doi.org/10.2967/jnumed.123.265935

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Immuno-PET imaging of cell-surface molecules. (A) Immuno-PET directed to CD4+ T cells for imaging colitis. Representative CT and PET/CT images of healthy and DSS-induced colitis mice were acquired 20 h after injection of [89Zr]Zr-mal-DFO-GK1.5 cys-diabody. Colon of DSS-treated mice showed high uptake of radiotracer, whereas healthy control mice showed little to no uptake in colon. (B) PET imaging of system xC– in mice given DSS (top panel) using [18F]FSPG shows increased tracer uptake in colon (white arrows). Inflammation (black arrows) in the distal colon, sigmoid colon, and rectum (middle panel) was delineated by same tracer in 55-y-old male UC patient, as shown in maximum-intensity projection images. Axial PET images (bottom, left) provide semiquantitative measurement of tracer uptake, which correlates with endoscopic image of colon (bottom, right). (C) [89Zr]Zr-α-CD11b PET imaging of colonic inflammation. Shown are representative PET images of DSS and healthy mice after injection of radiotracer. Increased uptake of [89Zr]Zr-α-CD11b was observed in inflamed colon compared with control. ALN = axillary lymph node; B = bone; Bl = bladder; CLN = cervical lymph node; ILN = inguinal lymph node; Ki = kidney; Li = liver; MIP = maximum-intensity projection; MLN = mesenteric lymph node; Pa = pancreas; PLN = popliteal lymph node; Sp= spleen; St = stomach; Ur = ureter. (Reprinted from (5,12,13).)

  • FIGURE 2.
    FIGURE 2.

    Immuno-PET imaging of inflammatory cytokines in IBD. (A) Immuno-PET imaging of TNF-α in colitis mice. Shown are representative PET images of control, DSS-treated, and blocked DSS-treated mice at different time points after injection of [89Zr]Zr-DFO-infliximab. Tracer clearly delineated inflamed colon as early as 2 h after injection. (Reprinted with permission of (14).) (B) [89Zr]Zr-a-IL-1β PET imaging of colonic inflammation. Shown are representative PET images of DSS and healthy mice acquired 24 h after injection of tracer. (Reprinted from (5).) (C) Immuno-PET/CT imaging of IL-12/23p40 in healthy and DSS-treated mice. Shown are representative PET/CT (maximum-intensity projection) images of healthy and colitis mice acquired at 24 and 48 h after injection of [89Zr]Zr-DFO-anti-IL-12/23p40. Tracer clearly delineated intestinal inflammation. (Reprinted from (34).) Li = liver.

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