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Research ArticleBasic Science Investigation
Open Access

[123I]CC1: A PARP-Targeting, Auger Electron–Emitting Radiopharmaceutical for Radionuclide Therapy of Cancer

Chung Ying Chan, Zijun Chen, Florian Guibbal, Gemma Dias, Gianluca Destro, Edward O’Neill, Mathew Veal, Doreen Lau, Michael Mosley, Thomas C. Wilson, Véronique Gouverneur and Bart Cornelissen
Journal of Nuclear Medicine September 2023, jnumed.123.265429; DOI: https://doi.org/10.2967/jnumed.123.265429
Chung Ying Chan
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
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Zijun Chen
2Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and
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Florian Guibbal
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
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Gemma Dias
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
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Gianluca Destro
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
2Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and
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Edward O’Neill
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
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Mathew Veal
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
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Doreen Lau
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
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Michael Mosley
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
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Thomas C. Wilson
2Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and
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Véronique Gouverneur
2Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and
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Bart Cornelissen
1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
3Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Article Information

jnumed.123.265429
DOI 
https://doi.org/10.2967/jnumed.123.265429
PubMed 
37770109

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication January 13, 2023
  • Revision received May 24, 2023
  • Published online September 28, 2023.

Article Versions

  • You are currently viewing a previous version of this article (September 28, 2023 - 08:44).
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Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Chung Ying Chan1,
  2. Zijun Chen2,
  3. Florian Guibbal1,
  4. Gemma Dias1,
  5. Gianluca Destro1,2,
  6. Edward O’Neill1,
  7. Mathew Veal1,
  8. Doreen Lau1,
  9. Michael Mosley1,
  10. Thomas C. Wilson2,
  11. Véronique Gouverneur2 and
  12. Bart Cornelissen1,3
  1. 1MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom;
  2. 2Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom; and
  3. 3Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  1. For correspondence or reprints, contact Bart Cornelissen (bart.cornelissen{at}oncology.ox.ac.uk).
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Journal of Nuclear Medicine: 66 (5)
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[123I]CC1: A PARP-Targeting, Auger Electron–Emitting Radiopharmaceutical for Radionuclide Therapy of Cancer
Chung Ying Chan, Zijun Chen, Florian Guibbal, Gemma Dias, Gianluca Destro, Edward O’Neill, Mathew Veal, Doreen Lau, Michael Mosley, Thomas C. Wilson, Véronique Gouverneur, Bart Cornelissen
Journal of Nuclear Medicine Sep 2023, jnumed.123.265429; DOI: 10.2967/jnumed.123.265429

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[123I]CC1: A PARP-Targeting, Auger Electron–Emitting Radiopharmaceutical for Radionuclide Therapy of Cancer
Chung Ying Chan, Zijun Chen, Florian Guibbal, Gemma Dias, Gianluca Destro, Edward O’Neill, Mathew Veal, Doreen Lau, Michael Mosley, Thomas C. Wilson, Véronique Gouverneur, Bart Cornelissen
Journal of Nuclear Medicine Sep 2023, jnumed.123.265429; DOI: 10.2967/jnumed.123.265429
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Keywords

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