MITIGATE-NeoBOMB1, a Phase I/IIa Study to Evaluate Safety, Pharmacokinetics and Preliminary Imaging of 68Ga-NeoBOMB1, a Gastrin-releasing Peptide Receptor Antagonist, in GIST Patients

Leonhard Gruber; Luis David Jimenez-Franco; Clemens Decristoforo; Christian Uprimny; Gerhard Glatting; Peter Hohenberger; Stefan O. Schoenberg; Wolfgang Reindl; Fransesca Orlandi; Maurizio Mariani; Werner Jaschke; Irene Johanna Virgolini

doi:10.2967/jnumed.119.238808

OtherClinical Investigations (Human)

MITIGATE-NeoBOMB1, a Phase I/IIa Study to Evaluate Safety, Pharmacokinetics and Preliminary Imaging of ⁶⁸Ga-NeoBOMB1, a Gastrin-releasing Peptide Receptor Antagonist, in GIST Patients

Leonhard Gruber, Luis David Jimenez-Franco, Clemens Decristoforo, Christian Uprimny, Gerhard Glatting, Peter Hohenberger, Stefan O. Schoenberg, Wolfgang Reindl, Fransesca Orlandi, Maurizio Mariani, Werner Jaschke and Irene Johanna Virgolini

Journal of Nuclear Medicine April 2020, jnumed.119.238808; DOI: https://doi.org/10.2967/jnumed.119.238808

Leonhard Gruber

1 Medical University Innsbruck, Department of Radiology, Austria;

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Luis David Jimenez-Franco

2 Medical Radiation Physics/Radiation Protection, Universitaetsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Germany;

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Clemens Decristoforo

3 Medical University Innsbruck, Department of Nuclear Medicine, Austria;

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Christian Uprimny

3 Medical University Innsbruck, Department of Nuclear Medicine, Austria;

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Gerhard Glatting

4 Medical Radiation Physics/Radiation Protection, Universitaetsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany, Germany;

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Peter Hohenberger

5 Division of Surgical Oncology and Thoracic Surgery, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Germany;

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Stefan O. Schoenberg

6 Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Germany;

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Wolfgang Reindl

7 Klinikum Mannheim II, Medizinische Klinik, Mannheim, Germany, Germany;

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Fransesca Orlandi

8 Advanced Accelerator Applications, 10010 Colleretto Giacosa TO, Italy, Italy;

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Maurizio Mariani

8 Advanced Accelerator Applications, 10010 Colleretto Giacosa TO, Italy, Italy;

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Werner Jaschke

9 Department of Radiology, Medical University Innsbruck, Austria, Austria

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Irene Johanna Virgolini

3 Medical University Innsbruck, Department of Nuclear Medicine, Austria;

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May 1, 2025

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MITIGATE-NeoBOMB1, a Phase I/IIa Study to Evaluate Safety, Pharmacokinetics and Preliminary Imaging of ⁶⁸Ga-NeoBOMB1, a Gastrin-releasing Peptide Receptor Antagonist, in GIST Patients

Journal of Nuclear Medicine Apr 2020, jnumed.119.238808; DOI: 10.2967/jnumed.119.238808

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MITIGATE-NeoBOMB1, a Phase I/IIa Study to Evaluate Safety, Pharmacokinetics and Preliminary Imaging of ⁶⁸Ga-NeoBOMB1, a Gastrin-releasing Peptide Receptor Antagonist, in GIST Patients

Journal of Nuclear Medicine Apr 2020, jnumed.119.238808; DOI: 10.2967/jnumed.119.238808

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Keywords

Molecular imaging
Oncology: GI
PET/CT
radiotracer tissue kinetics
68Ga-NeoBOMB1
GIST
GRPR
PET
Phase I/IIa study

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MITIGATE-NeoBOMB1, a Phase I/IIa Study to Evaluate Safety, Pharmacokinetics and Preliminary Imaging of ⁶⁸Ga-NeoBOMB1, a Gastrin-releasing Peptide Receptor Antagonist, in GIST Patients

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