Imaging P-glycoprotein Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with 11C-Metoclopramide PET

Viktoria Zoufal; Severin Mairinger; Mirjam Brackhan; Markus Krohn; Thomas Filip; Michael Sauberer; Johann Stanek; Thomas Wanek; Nicolas Tournier; Martin Bauer; Jens Pahnke; Oliver Langer

doi:10.2967/jnumed.119.237198

OtherBasic Science (Animal or Phantoms)

Imaging P-glycoprotein Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with ¹¹C-Metoclopramide PET

Viktoria Zoufal, Severin Mairinger, Mirjam Brackhan, Markus Krohn, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Wanek, Nicolas Tournier, Martin Bauer, Jens Pahnke and Oliver Langer

Journal of Nuclear Medicine December 2019, jnumed.119.237198; DOI: https://doi.org/10.2967/jnumed.119.237198

Viktoria Zoufal

1 AIT Austrian Institute of Technology GmbH, Austria;

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Severin Mairinger

1 AIT Austrian Institute of Technology GmbH, Austria;

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Mirjam Brackhan

2 University of Oslo, Norway;

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Markus Krohn

2 University of Oslo, Norway;

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Thomas Filip

1 AIT Austrian Institute of Technology GmbH, Austria;

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Michael Sauberer

1 AIT Austrian Institute of Technology GmbH, Austria;

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Johann Stanek

1 AIT Austrian Institute of Technology GmbH, Austria;

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Thomas Wanek

1 AIT Austrian Institute of Technology GmbH, Austria;

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Nicolas Tournier

3 CEA-SHFJ, France;

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Martin Bauer

4 Medical University of Vienna, Austria

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Jens Pahnke

2 University of Oslo, Norway;

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Oliver Langer

1 AIT Austrian Institute of Technology GmbH, Austria;

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ORCID record for Oliver Langer

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Journal of Nuclear Medicine

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May 1, 2025

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Imaging P-glycoprotein Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with ¹¹C-Metoclopramide PET

Viktoria Zoufal, Severin Mairinger, Mirjam Brackhan, Markus Krohn, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Wanek, Nicolas Tournier, Martin Bauer, Jens Pahnke, Oliver Langer

Journal of Nuclear Medicine Dec 2019, jnumed.119.237198; DOI: 10.2967/jnumed.119.237198

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Imaging P-glycoprotein Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with ¹¹C-Metoclopramide PET

Viktoria Zoufal, Severin Mairinger, Mirjam Brackhan, Markus Krohn, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Wanek, Nicolas Tournier, Martin Bauer, Jens Pahnke, Oliver Langer

Journal of Nuclear Medicine Dec 2019, jnumed.119.237198; DOI: 10.2967/jnumed.119.237198

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Keywords

Animal Imaging
Neurology
PET
11C-metoclopramide
APP/PS1-21 mice
Alzheimer disease
P-glycoprotein induction
beta-amyloid clearance

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Imaging P-glycoprotein Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with ¹¹C-Metoclopramide PET

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