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OtherClinical Investigations (Human)

Tau PET imaging with 18F-PI-2620 in patients with Alzheimer's disease and healthy controls: a first-in-human study

Andre Mueller, Santiago Bullich, Olivier Barret, Jennifer Madonia, Mathias Berndt, Caroline Papin, Audrey Perrotin, Norman Koglin, Heiko Kroth, Andrea Pfeifer, Gilles Tamagnan, John P Seibyl, Kenneth Marek, Susan de Santi, Ludger M Dinkelborg and Andrew W Stephens
Journal of Nuclear Medicine November 2019, jnumed.119.236224; DOI: https://doi.org/10.2967/jnumed.119.236224
Andre Mueller
1 Life Molecular Imaging GmbH, Germany;
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Santiago Bullich
1 Life Molecular Imaging GmbH, Germany;
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Olivier Barret
2 Invicro LLC, United States;
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Jennifer Madonia
2 Invicro LLC, United States;
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Mathias Berndt
1 Life Molecular Imaging GmbH, Germany;
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Caroline Papin
1 Life Molecular Imaging GmbH, Germany;
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Audrey Perrotin
1 Life Molecular Imaging GmbH, Germany;
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Norman Koglin
3 Life Molecular Imaging GmbH, Germany;
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Heiko Kroth
4 AC Immune SA, Switzerland;
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Andrea Pfeifer
4 AC Immune SA, Switzerland;
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Gilles Tamagnan
2 Invicro LLC, United States;
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John P Seibyl
2 Invicro LLC, United States;
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Kenneth Marek
2 Invicro LLC, United States;
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Susan de Santi
5 Life Molecular Imaging Inc, United States
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Ludger M Dinkelborg
1 Life Molecular Imaging GmbH, Germany;
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Andrew W Stephens
1 Life Molecular Imaging GmbH, Germany;
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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Tau PET imaging with 18F-PI-2620 in patients with Alzheimer's disease and healthy controls: a first-in-human study
Andre Mueller, Santiago Bullich, Olivier Barret, Jennifer Madonia, Mathias Berndt, Caroline Papin, Audrey Perrotin, Norman Koglin, Heiko Kroth, Andrea Pfeifer, Gilles Tamagnan, John P Seibyl, Kenneth Marek, Susan de Santi, Ludger M Dinkelborg, Andrew W Stephens
Journal of Nuclear Medicine Nov 2019, jnumed.119.236224; DOI: 10.2967/jnumed.119.236224

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Tau PET imaging with 18F-PI-2620 in patients with Alzheimer's disease and healthy controls: a first-in-human study
Andre Mueller, Santiago Bullich, Olivier Barret, Jennifer Madonia, Mathias Berndt, Caroline Papin, Audrey Perrotin, Norman Koglin, Heiko Kroth, Andrea Pfeifer, Gilles Tamagnan, John P Seibyl, Kenneth Marek, Susan de Santi, Ludger M Dinkelborg, Andrew W Stephens
Journal of Nuclear Medicine Nov 2019, jnumed.119.236224; DOI: 10.2967/jnumed.119.236224
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Cited By...

  • In Vivo Head-to-Head Comparison of [18F]GTP1 with [18F]MK-6240 and [18F]PI-2620 in Alzheimer Disease
  • Assessment and staging of A/T/N with a single dynamic [18F]PI-2620 recording
  • Diagnostic Reference Levels in PET Imaging at Chulabhorn Hospital, Thailand
  • Quantitative PET imaging and modeling of molecular blood-brain barrier permeability
  • Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer's Disease
  • One-Year Longitudinal Changes in Tau Accumulation on [18F]PI-2620 PET in the Alzheimer Spectrum
  • [18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration
  • Fibril Paint to detect Amyloids and determine Fibril Length
  • PRedicting the EVolution of SubjectIvE Cognitive Decline to Alzheimers Disease With machine learning: the PREVIEW study protocol
  • Individual regional associations between A{beta}-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies
  • Stacked binding of a small molecule PET tracer to Alzheimers tau paired helical filaments
  • Multimodality Imaging in Primary Progressive Aphasia
  • An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with 18F-PM-PBB3 (18F-APN-1607)
  • TauIQ: A Canonical Image Based Algorithm to Quantify Tau PET Scans
  • In vivo visualization of propagating {alpha}-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05
  • Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers
  • Evaluation of Dosimetry, Quantitative Methods, and Test-Retest Variability of 18F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain
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Keywords

  • Neurology
  • PET/CT
  • radiopharmaceuticals
  • Alzheimer’s disease
  • PET
  • PI-2620
  • Positron Emission Tomography
  • tau
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