Journal of Nuclear Medicine: 66 (6)

June 1, 2025; Volume 66,Issue 6

Editor’s Page

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Funding Reductions Threaten the Future of Medical Innovation
Johannes Czernin, Carolyn J. Anderson, Ramsey Derek Badawi, Henryk Barthel, Frank M. Bengel, Thomas Beyer, Irene Buvat, Jérémie Calais, Sharmila Dorbala, Alexander E. Drzezga, Ken Herrmann, Thomas A. Hope, Hossein Jadvar, David A. Mankoff, Heinrich R. Schelbert and Wolfgang A. Weber

Journal of Nuclear Medicine June 1, 2025, 66 (6) 829; DOI: https://doi.org/10.2967/jnumed.125.270157

Discussions with Leaders

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Stakeholders of Theranostics
Richard Zimmermann and Thomas Beyer

Journal of Nuclear Medicine June 1, 2025, 66 (6) 830-832; DOI: https://doi.org/10.2967/jnumed.125.270085

The State of the Art

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The Role of PSMA PET Parameters as Biomarkers for Response to PSMA-Targeted Radiopharmaceutical Therapy
Vishnu Murthy, Vinicius Ludwig, Andrei Gafita, Thomas A. Hope and Jeremie Calais

Journal of Nuclear Medicine June 1, 2025, 66 (6) 833-838; DOI: https://doi.org/10.2967/jnumed.124.268818

Continuing Education

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Approaches to Imaging Immune Activation Using PET
Ashwin Singh Parihar, Niharika Pant, Pedram Heidari, Lawrence Fong and Amir Iravani

Journal of Nuclear Medicine June 1, 2025, 66 (6) 839-847; DOI: https://doi.org/10.2967/jnumed.124.268289

Hot Topics

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Diagnostic Radiopharmaceutical Trial Design: Is It Time to Change Nomenclature?
Rodney J. Hicks

Journal of Nuclear Medicine June 1, 2025, 66 (6) 848-850; DOI: https://doi.org/10.2967/jnumed.125.269496

Focus on Molecular Imaging

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From Genome to Phenome: Opportunities and Challenges of Molecular Imaging
Mei Tian, Leroy Hood, Arturo Chiti, Markus Schwaiger, Satoshi Minoshima, Yasuyoshi Watanabe, Keon Wook Kang and Hong Zhang

Journal of Nuclear Medicine June 1, 2025, 66 (6) 851-855; DOI: https://doi.org/10.2967/jnumed.124.267660

Highlights

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2024 SNMMI Highlights Lecture: Cardiovascular Sciences
James T. Thackeray

Journal of Nuclear Medicine June 1, 2025, 66 (6) 856-861; DOI: https://doi.org/10.2967/jnumed.125.269988

Editorial

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FDA Approval of ¹⁸F-Flurpiridaz for PET: Stepping into a New Era of Myocardial Perfusion Imaging?
Thomas H. Schindler, Timothy M. Bateman, Daniel S. Berman, Panithaya Chareonthaitawee, Lorraine E. De Blanche, Vasken Dilsizian, Sharmila Dorbala, Robert J. Gropler, Leslee L. Shaw, Prem Soman, David E. Winchester, Hein J. Verberne, Sukhjeet Ahuja, Rob Beanlands, Marcelo Di Carli, Venkatesh L. Murthy, Terrence D. Ruddy and Ronald G. Schwartz

Journal of Nuclear Medicine June 1, 2025, 66 (6) 862-864; DOI: https://doi.org/10.2967/jnumed.124.269154

Oncology

Clinical
- FEATURED ARTICLE OF THE MONTH
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    CD70-Targeted [¹⁸F]RCCB6 Immuno-PET/CT Imaging in Patients with Nasopharyngeal Carcinoma: A Proof-of-Concept Study
    Binyu Shi, You Zhang, Shuo Wu, Dongsheng Xu, Qianyun Wu, Wenzhi Jia, Shuxian An, Cheng Wang, Yongrui Bai, Jianjun Liu, Junjun Zhou and Weijun Wei
    
    Journal of Nuclear Medicine June 1, 2025, 66 (6) 865-872; DOI: https://doi.org/10.2967/jnumed.125.269585
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  Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis
  Randy Yeh, Fresia Pareja, Parnian Shobeiri, Dara Ross, Vetri S. Jayaprakasam, Ali Aria Razmaria, Joshua Z. Drago, Audrey Mauguen, Serge K. Lyashchenko, Brian M. Zeglis, Jason S. Lewis and Gary A. Ulaner
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 873-879; DOI: https://doi.org/10.2967/jnumed.124.269227
Basic
- FEATURED BASIC SCIENCE ARTICLE
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    Targeting Extra Domain A of Fibronectin to Improve Noninvasive Detection of Triple-Negative Breast Cancer
    Justin S. Hachey, Tara D. Viray, Mattia Matasci, Domenico Ravazza, Dario Neri and Jason S. Lewis
    
    Journal of Nuclear Medicine June 1, 2025, 66 (6) 880-885; DOI: https://doi.org/10.2967/jnumed.124.268859

Theranostics and Radiopharmaceutical Therapies

Clinical
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  Determination of the Intralesional Distribution of Theranostic ¹²⁴I-Omburtamab Convection-Enhanced Delivery in Treatment of Diffuse Intrinsic Pontine Glioma
  Alexandre França Velo, Alexandra Giantini Larsen, John L. Humm, Pat Zanzonico, Sofia Haque, Mark Souweidane and Neeta Pandit-Taskar
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 886-891; DOI: https://doi.org/10.2967/jnumed.124.267995
- BRIEF COMMUNICATION
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    Prostate Cancer Recurrence Due to Isolated Testicular Metastases Detected by PSMA PET/CT
    Mateus de Oliveira Taveira, Ali Aria Razmaria, Heiko Schoder and Randy Yeh
    
    Journal of Nuclear Medicine June 1, 2025, 66 (6) 892-895; DOI: https://doi.org/10.2967/jnumed.124.269361
- BRIEF COMMUNICATION
  - Open Access
    First-in-Human Serum Stability Studies of [¹⁷⁷Lu]Lu-AMTG: A Step Toward Improved GRPR-Targeted Radiopharmaceutical Therapy
    Veronika Felber, Nadine Holzleitner, Markus Joksch, Tim Suhrbier, Gunhild von Amsberg, Sarah Schwarzenböck, Jens Kurth, Martin Heuschkel, Thomas Günther and Bernd J. Krause
    
    Journal of Nuclear Medicine June 1, 2025, 66 (6) 896-899; DOI: https://doi.org/10.2967/jnumed.124.269132
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  Multicycle Dosimetric Behavior and Dose–Effect Relationships in [¹⁷⁷Lu]Lu-DOTATATE Peptide Receptor Radionuclide Therapy
  Gunjan Kayal, Molly E. Roseland, Chang Wang, Kellen Fitzpatrick, David Mirando, Krithika Suresh, Ka Kit Wong and Yuni K. Dewaraja
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 900-908; DOI: https://doi.org/10.2967/jnumed.124.269389
Basic
- Open Access
  ¹⁶¹Tb Radioimmunotherapy as a Treatment for CD30-Positive Lymphomas
  Elisa Rioja-Blanco, Yara Banz, Christoph Schlapbach, Urban Novak, Tanja Chiorazzo, Nicole L. Bertschi, Peter Bernhardt, Pascal V. Grundler, Nicholas P. van der Meulen, Michal Grzmil, Roger Schibli and Martin Behe
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 909-915; DOI: https://doi.org/10.2967/jnumed.124.268805
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  ²¹²Bi-Macroaggregated Albumin Inhibited Mouse Melanoma Growth by Regulating Cell Cycle Checkpoint Markers Without Promoting Living Cell Repopulation
  Satyendra Kumar Singh, Nathan Kauffman, Isabelle Maria Lynch, Zeynep Meral Kunt, Kurt R. Zinn, Dalen Agnew and Jinda Fan
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 916-921; DOI: https://doi.org/10.2967/jnumed.124.269190

Endocrinology

Clinical
- BRIEF COMMUNICATION
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    Initial Experience with Dual-Time-Point [¹⁸F]Flurpiridaz PET/CT for Localization of Parathyroid Adenomas in Primary Hyperparathyroidism
    Thorsten Derlin, Dennis Kleine-Döpke, Lavinia Neubert, Tobias L. Ross, Bastian P. Ringe, Moritz Schmelzle and Frank M. Bengel
    
    Journal of Nuclear Medicine June 1, 2025, 66 (6) 922-925; DOI: https://doi.org/10.2967/jnumed.124.269387

Neurology

Clinical
- Open Access
  [¹⁸F]Florzolotau PET for the Differential Diagnosis of Parkinsonism in Patients with Suspected 4-Repeat Tauopathies
  Joachim Brumberg, Nils Schröter, Ganna Blazhenets, M. Aymen Omrane, Christian Volz, Cornelius Weiller, Michel Rijntjes, Lars Frings, Sabine Hellwig, Wolfgang H. Jost and Philipp T. Meyer
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 926-931; DOI: https://doi.org/10.2967/jnumed.124.268956
- Open Access
  First-in-Human Study of ¹⁸F-Labeled PET Tracer for Glutamate AMPA Receptor [¹⁸F]K-40: A Derivative of [¹¹C]K-2
  Sadamitsu Ichijo, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Tomoyuki Miyazaki, Tsuyoshi Eiro, Yuuki Takada, Ryunosuke Iai, Akane Sano, Masaki Sonoda, Yutaro Takayama, Yuichi Kimura and Takuya Takahashi
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 932-939; DOI: https://doi.org/10.2967/jnumed.124.269405
Basic
- Open Access
  In Vivo Visualization and Quantification of Brain Heat Shock Protein 90 with [¹¹C]HSP990 in Healthy Aging and Neurodegeneration
  Romy Cools, Koen Vermeulen, Eline Vonck, Veerle Baekelandt, Cassis Varlow, Valeria Narykina, Christopher Cawthorne, Koen Van Laere, Wim Vanduffel, Neil Vasdev and Guy Bormans
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 940-947; DOI: https://doi.org/10.2967/jnumed.124.268961

AI/Advanced Image Analysis

Clinical
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  An External, Independent Validation of an O-(2-[¹⁸F]Fluoroethyl)-l-Tyrosine PET Automatic Segmentation Network on a Single-Center, Prospective Dataset of Patients with Glioblastoma
  Nathaniel Barry, Jake Kendrick, Pejman Rowshanfarzad, Ghulam Mubashar Hassan, Roslyn J. Francis, Nicholas Bucknell, Eng-Siew Koh, Andrew M. Scott, Martin A. Ebert, Robin Gutsche, Keith George Ciantar, Norbert Galldiks, Karl-Josef Langen and Philipp Lohmann
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 948-953; DOI: https://doi.org/10.2967/jnumed.124.268925

Physics and Instrumentation

Clinical
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  Is Long–Axial-Field-of-View PET/CT Cost-Effective? An International Health–Economic Analysis
  Ian Alberts, Stuart More, Karen Knapp, Riccardo Mei, Stefano Fanti, Clemens Mingels, Lorenzo Nardo, Nii Boye Hammond, Harish Nagaraj, Axel Rominger, Gary J.R. Cook and Don Wilson
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 954-960; DOI: https://doi.org/10.2967/jnumed.124.269203
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  Feasibility of Ultra-Low-Activity ¹⁸F-FDG PET/CT Imaging Using a Long–Axial-Field-of-View PET/CT System
  Charlotte L.C. Smith, Gerben J. C. Zwezerijnen, Marijke E. den Hollander, Josée M. Zijlstra, C. Willemien Menke-van der Houven van Oordt, Idris Bahce, Maqsood Yaqub and Ronald Boellaard
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 961-966; DOI: https://doi.org/10.2967/jnumed.124.269272
- BRIEF COMMUNICATION
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    Feasibility of an Ultra-Low-Dose PET Scan Protocol with CT-Based and LSO-TX–Based Attenuation Correction Using a Long–Axial-Field-of-View PET/CT Scanner
    Hasan Sari, Mohammadreza Teimoorisichani, Marco Viscione, Clemens Mingels, Robert Seifert, Kuangyu Shi, Michael Morris, Eliot Siegel, Babak Saboury, Thomas Pyka and Axel Rominger
    
    Journal of Nuclear Medicine June 1, 2025, 66 (6) 967-972; DOI: https://doi.org/10.2967/jnumed.124.268380
Translational
- Open Access
  Quantitative Total-Body Imaging of Blood Flow with High-Temporal-Resolution Early Dynamic ¹⁸F-FDG PET Kinetic Modeling
  Kevin J. Chung, Abhijit J. Chaudhari, Lorenzo Nardo, Terry Jones, Moon S. Chen, Ramsey D. Badawi, Simon R. Cherry and Guobao Wang
  
  Journal of Nuclear Medicine June 1, 2025, 66 (6) 973-980; DOI: https://doi.org/10.2967/jnumed.124.268706

The Illustrated Post

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Safety and Efficacy of 20 Cycles of [¹⁷⁷Lu]Lu-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer
Kerry E. Jewell, James P. Buteau, Elizabeth Medhurst, Edmond M. Kwan, Shahneen Sandhu, Arun A. Azad and Michael S. Hofman

Journal of Nuclear Medicine June 1, 2025, 66 (6) 981-982; DOI: https://doi.org/10.2967/jnumed.124.269447

Letters to the Editor

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Patient-Specific Dosimetry-Driven PRRT: Time to Move Forward!
Emmanuel Deshayes, Ioannis Karfis, Lore Santoro, Magdalena Mileva, Rachele Danieli, Kévin Hebert, Marco Maccauro, Carlo Chiesa and Manuel Bardiès

Journal of Nuclear Medicine June 1, 2025, 66 (6) 983; DOI: https://doi.org/10.2967/jnumed.124.268880
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[⁶⁸Ga]Ga-RAYZ-8009: A Peptide PET Tracer for Targeting HCC in Humans
Yue Zhang, Jiangtao Yue, Xuhong Yang, Guanghai Fei, Yicheng Ni and Yue Li

Journal of Nuclear Medicine June 1, 2025, 66 (6) 984; DOI: https://doi.org/10.2967/jnumed.124.269294
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The Randomized, Phase 2 Trial LuCAP Study
Murat Tuncel, Gürsan Kaya, Oğuz Kodaz, Cem Türkan and Meltem Çağlar Tuncalı

Journal of Nuclear Medicine June 1, 2025, 66 (6) 984-985; DOI: https://doi.org/10.2967/jnumed.125.269549
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Reply to “The Randomized, Phase 2 LuCAP Study”
Swayamjeet Satapathy and Ashwani Sood

Journal of Nuclear Medicine June 1, 2025, 66 (6) 986; DOI: https://doi.org/10.2967/jnumed.125.270026
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FDA Reconsiders Rules Around Radiation Dosimetry for First-in-Human Studies of Investigational PET Radiopharmaceuticals
Marianna Dakanali, Steven S. Zigler, Sally W. Schwarz, Michael L. Nickels, Reiko Oyama, Henry F. VanBrocklin and Peter J. H. Scott

Journal of Nuclear Medicine June 1, 2025, 66 (6) 986-988; DOI: https://doi.org/10.2967/jnumed.125.269885
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Business Model Beats Science and Logic: Dosimetry and Paucity of Its Use
Michael D.F. Goldenberg, Taranjit S. Gill and Jitesh Dhingra

Journal of Nuclear Medicine June 1, 2025, 66 (6) 988; DOI: https://doi.org/10.2967/jnumed.125.269865

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Table of Contents

Editor’s Page

Discussions with Leaders

The State of the Art

Continuing Education

Hot Topics

Focus on Molecular Imaging

Highlights

Editorial

Oncology

Clinical

FEATURED ARTICLE OF THE MONTH

Basic

FEATURED BASIC SCIENCE ARTICLE

Theranostics and Radiopharmaceutical Therapies

Clinical

BRIEF COMMUNICATION

BRIEF COMMUNICATION

Basic

Endocrinology

Clinical

BRIEF COMMUNICATION

Neurology

Clinical

Basic

AI/Advanced Image Analysis

Clinical

Physics and Instrumentation

Clinical

BRIEF COMMUNICATION

Translational

The Illustrated Post

Letters to the Editor

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