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OtherClinical Investigations (Human)

Synthesis and Preliminary Evaluation of Phenyl 4-123I-iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer’s Disease Pathology

Ian R Macdonald, George Andrew Reid, Ian R Pottie, Earl Martin and Sultan Darvesh
Journal of Nuclear Medicine November 2015, jnumed.115.162032; DOI: https://doi.org/10.2967/jnumed.115.162032
Ian R Macdonald
1 Dalhousie University, Canada;
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George Andrew Reid
1 Dalhousie University, Canada;
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Ian R Pottie
2 Mount Saint Vincent University, Canada
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Earl Martin
2 Mount Saint Vincent University, Canada
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Sultan Darvesh
1 Dalhousie University, Canada;
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Article Information

jnumed.115.162032
DOI 
https://doi.org/10.2967/jnumed.115.162032
PubMed 
26541777

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Published online November 5, 2015.

Article Versions

  • You are currently viewing a previous version of this article (November 5, 2015 - 06:07).
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Copyright & Usage 
Copyright © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Ian R Macdonald1,
  2. George Andrew Reid1,
  3. Ian R Pottie2,
  4. Earl Martin2 and
  5. Sultan Darvesh1
  1. 1 Dalhousie University, Canada;
  2. 2 Mount Saint Vincent University, Canada
  1. For correspondence or reprints contact: Sultan Darvesh, Dalhousie University, Room 1308, Camp Hill Veterans' Memorial, 5955 Veterans' Memorial Lane, Halifax, Nova Scotia B3H 2E1, Canada. E-mail: sultan.darvesh@dal.ca

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Cited By...

  • 12 Citations
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer’s Disease
    Ian R. Macdonald, Selena P. Maxwell, George A. Reid, Meghan K. Cash, Drew R. DeBay, Sultan Darvesh, Debomoy Lahiri
    Journal of Alzheimer’s Disease 2017 58 2
  • Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT
    Brian P. Rempel, Eric W. Price, Christopher P. Phenix
    Molecular Imaging 2017 16
  • Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease
    Drew R. DeBay, George A. Reid, Ian R. Pottie, Earl Martin, Chris V. Bowen, Sultan Darvesh
    Alzheimer's & Dementia: Translational Research & Clinical Interventions 2017 3 2
  • Imaging Butyrylcholinesterase in Multiple Sclerosis
    M. W. D. Thorne, M. K. Cash, G. A. Reid, D. E. Burley, D. Luke, I. R. Pottie, S. Darvesh
    Molecular Imaging and Biology 2021 23 1
  • Neuroprotective, neurite enhancing, and cholinesterase inhibitory effects of Lamiaceae family essential oils in Alzheimer’s disease model
    Win Ning Chen, Kar Wei Chin, Kim San Tang, Snezana Agatonovic-Kustrin, Keng Yoon Yeong
    Journal of Herbal Medicine 2023 41
  • Synthesis and Initial Characterization of a Selective, Pseudo‐irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer
    Christian Gentzsch, Matthias Hoffmann, Yasuhiro Ohshima, Naoko Nose, Xinyu Chen, Takahiro Higuchi, Michael Decker
    ChemMedChem 2021 16 9
  • Biometals in Alzheimer disease: emerging therapeutic and diagnostic potential of molybdenum and iodine
    Benson O. A. Botchway, Xuehong Liu, Yu Zhou, Marong Fang
    Journal of Translational Medicine 2023 21 1
  • Cholinesterases in normal and Alzheimer's disease primary olfactory gyrus
    H. Hamodat, M. K. Cash, J. D. Fisk, S. Darvesh
    Neuropathology and Applied Neurobiology 2017 43 7
  • Synthesis and Initial Characterization of a Reversible, Selective 18F-Labeled Radiotracer for Human Butyrylcholinesterase
    Christian Gentzsch, Xinyu Chen, Philipp Spatz, Urban Košak, Damijan Knez, Naoko Nose, Stanislav Gobec, Takahiro Higuchi, Michael Decker
    Molecular Imaging and Biology 2021 23 4
  • Solvents and detergents compatible with enzyme kinetic studies of cholinesterases
    Dane Sands, Andrew Davis, Scott Banfield, Ian R. Pottie, Sultan Darvesh
    Chemico-Biological Interactions 2023 383

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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
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Synthesis and Preliminary Evaluation of Phenyl 4-123I-iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer’s Disease Pathology
Ian R Macdonald, George Andrew Reid, Ian R Pottie, Earl Martin, Sultan Darvesh
Journal of Nuclear Medicine Nov 2015, jnumed.115.162032; DOI: 10.2967/jnumed.115.162032

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Synthesis and Preliminary Evaluation of Phenyl 4-123I-iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer’s Disease Pathology
Ian R Macdonald, George Andrew Reid, Ian R Pottie, Earl Martin, Sultan Darvesh
Journal of Nuclear Medicine Nov 2015, jnumed.115.162032; DOI: 10.2967/jnumed.115.162032
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Keywords

  • autoradiography
  • Neurology
  • radiochemistry
  • Acetylcholinesterase
  • Alzheimer's disease
  • Butyrylcholinesterase
  • Carbamate
  • single photon emission computed tomography
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