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Criteria Definition New lesion Any new focal uptake of PSMA ligand • Higher than surrounding background • With tumor SUVmax > blood-pool SUVmax • Not present on baseline scan (tumor SUVmax < blood-pool SUVmax), with tumor uptake not attributable to physiologic uptake or pitfalls Any new malignant lesion detected on follow-up CT images independent of PSMA ligand uptake RECIP 1.0 RECIP-CR Absence of any PSMA uptake on follow-up PET scan RECIP-PR Significant reduction (quantitatively, ≥30%) in PSMA-VOL without appearance of new lesions RECIP-PD Significant increase (quantitatively, ≥20%) in PSMA-VOL with appearance of new lesions RECIP-SD None of the above CR = complete response; PR = partial response; PD = progressive disease; SD = stable disease.
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