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Research ArticleFEATURED ARTICLE OF THE MONTH

PET Imaging of Fibroblast Activation Protein in Various Types of Cancer Using 68Ga-FAP-2286: Comparison with 18F-FDG and 68Ga-FAPI-46 in a Single-Center, Prospective Study

Yizhen Pang, Liang Zhao, Tinghua Meng, Weizhi Xu, Qin Lin, Hua Wu, Jingjing Zhang, Xiaoyuan Chen, Long Sun and Haojun Chen
Journal of Nuclear Medicine March 2023, 64 (3) 386-394; DOI: https://doi.org/10.2967/jnumed.122.264544
Yizhen Pang
1Department of Nuclear Medicine and Minnan PET Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;
2Department of Radiation Oncology, First Affiliated Hospital of Xiamen University, Xiamen, China;
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Liang Zhao
1Department of Nuclear Medicine and Minnan PET Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;
2Department of Radiation Oncology, First Affiliated Hospital of Xiamen University, Xiamen, China;
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Tinghua Meng
1Department of Nuclear Medicine and Minnan PET Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;
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Weizhi Xu
1Department of Nuclear Medicine and Minnan PET Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;
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Qin Lin
2Department of Radiation Oncology, First Affiliated Hospital of Xiamen University, Xiamen, China;
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Hua Wu
1Department of Nuclear Medicine and Minnan PET Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;
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Jingjing Zhang
3Department of Diagnostic Radiology, National University of Singapore, Singapore;
4Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
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Xiaoyuan Chen
4Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
5Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore; and
6Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Long Sun
1Department of Nuclear Medicine and Minnan PET Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;
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Haojun Chen
1Department of Nuclear Medicine and Minnan PET Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;
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Article Information

vol. 64 no. 3 386-394
DOI 
https://doi.org/10.2967/jnumed.122.264544
PubMed 
36215571

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 20, 2022
  • Revision received August 30, 2022
  • Published online March 2, 2023.

Article Versions

  • previous version (September 2, 2022 - 05:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Yizhen Pang*,1,2,
  2. Liang Zhao*,1,2,
  3. Tinghua Meng*,1,
  4. Weizhi Xu1,
  5. Qin Lin2,
  6. Hua Wu1,
  7. Jingjing Zhang3,4,
  8. Xiaoyuan Chen4,5,6,
  9. Long Sun1 and
  10. Haojun Chen1
  1. 1Department of Nuclear Medicine and Minnan PET Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;
  2. 2Department of Radiation Oncology, First Affiliated Hospital of Xiamen University, Xiamen, China;
  3. 3Department of Diagnostic Radiology, National University of Singapore, Singapore;
  4. 4Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
  5. 5Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore; and
  6. 6Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  1. For correspondence or reprints, contact Haojun Chen (leochen0821{at}foxmail.com), Long Sun (13178352662{at}163.com), or Xiaoyuan Chen (chen.shawn{at}nus.edu.sg).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 64 (3)
Journal of Nuclear Medicine
Vol. 64, Issue 3
March 1, 2023
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PET Imaging of Fibroblast Activation Protein in Various Types of Cancer Using 68Ga-FAP-2286: Comparison with 18F-FDG and 68Ga-FAPI-46 in a Single-Center, Prospective Study
Yizhen Pang, Liang Zhao, Tinghua Meng, Weizhi Xu, Qin Lin, Hua Wu, Jingjing Zhang, Xiaoyuan Chen, Long Sun, Haojun Chen
Journal of Nuclear Medicine Mar 2023, 64 (3) 386-394; DOI: 10.2967/jnumed.122.264544

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PET Imaging of Fibroblast Activation Protein in Various Types of Cancer Using 68Ga-FAP-2286: Comparison with 18F-FDG and 68Ga-FAPI-46 in a Single-Center, Prospective Study
Yizhen Pang, Liang Zhao, Tinghua Meng, Weizhi Xu, Qin Lin, Hua Wu, Jingjing Zhang, Xiaoyuan Chen, Long Sun, Haojun Chen
Journal of Nuclear Medicine Mar 2023, 64 (3) 386-394; DOI: 10.2967/jnumed.122.264544
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  • SNMMI Procedure Standard/EANM Practice Guideline for Fibroblast Activation Protein (FAP) PET
  • 68Ga-FAP-2286 PET of Solid Tumors: Biodistribution, Dosimetry, and Comparison with 18F-FDG
  • Initial Experience with 68Ga-FAP-2286 PET Imaging in Patients with Urothelial Cancer
  • Clinical Evaluation of 68Ga-FAPI-RGD for Imaging of Fibroblast Activation Protein and Integrin {alpha}v{beta}3 in Various Cancer Types
  • Clinical Evaluation of 68Ga-FAPI-RGD for Imaging of Fibroblast Activation Protein and Integrin {alpha}v{beta}3 in Various Cancer Types
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Keywords

  • fibroblast activation protein
  • FAP-2286
  • FAPI-46
  • PET/CT
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