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Table of Contents

March 1, 2023; Volume 64,Issue 3

This Month in JNM

  • You have access
    This Month in JNM
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 8A;

Editor's Page

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    The 177Lu-PSMA-617 (Pluvicto) Supply Problem Will Be Solved by Competition
    Johannes Czernin and Jeremie Calais
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 343; DOI: https://doi.org/10.2967/jnumed.123.265459

Discussions With Leaders

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    Focusing on Whole-Person Health
    Hélène Langevin and Ramsey Badawi
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 344-346; DOI: https://doi.org/10.2967/jnumed.123.265478

Hot Topics

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    Tackling the Last Mile: A Major Component to Successfully Establish Radioligand Therapy
    Kelsey L. Pomykala, Marcus Würker and Ken Herrmann
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 347-348; DOI: https://doi.org/10.2967/jnumed.122.264900

Editorial

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    Clinical Implementation of 177Lu-PSMA-617 in the United States: Lessons Learned and Ongoing Challenges
    Praful Ravi, Bridget Whelpley, Emma Kelly, Andrew Wolanski, Jolivette Ritzer, Matthew Robertson, Hina Shah, Alicia K. Morgans, Xiao X. Wei, Rajitha Sunkara, Mark Pomerantz, Mary-Ellen Taplin, Kerry L. Kilbridge, Atish D. Choudhury and Heather Jacene
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 349-350; DOI: https://doi.org/10.2967/jnumed.122.265194

Appropriate Use Criteria

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    Summary: Appropriate Use Criteria for Estrogen Receptor–Targeted PET Imaging with 16α-18F-Fluoro-17β-Fluoroestradiol
    Gary A. Ulaner, David A. Mankoff, Amy S. Clark, Amy M. Fowler, Hannah M. Linden, Lanell M. Peterson, Farrokh Dehdashti, Brenda F. Kurland, Joanne Mortimer, Jason Mouabbi, Dae Hyuk Moon and Elisabeth G.E. de Vries
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 351-354; DOI: https://doi.org/10.2967/jnumed.123.265420

Oncology

  • Clinical

    • Response Monitoring in Metastatic Breast Cancer: A Prospective Study Comparing <sup>18</sup>F-FDG PET/CT with Conventional CT
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      Response Monitoring in Metastatic Breast Cancer: A Prospective Study Comparing 18F-FDG PET/CT with Conventional CT
      Marianne Vogsen, Frederik Harbo, Nick M. Jakobsen, Henriette J. Nissen, Sara E. Dahlsgaard-Wallenius, Oke Gerke, Jeanette D. Jensen, Jon T. Asmussen, Anne Marie B. Jylling, Poul-Erik Braad, Werner Vach, Marianne Ewertz and Malene G. Hildebrandt
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 355-361; DOI: https://doi.org/10.2967/jnumed.121.263358
    • <sup>18</sup>F-FDG PET/CT Prediction of Treatment Outcomes in Human Papillomavirus–Positive, Locally Advanced Oropharyngeal Cancer Patients Receiving Deintensified Therapy: Results from NRG-HN002
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      18F-FDG PET/CT Prediction of Treatment Outcomes in Human Papillomavirus–Positive, Locally Advanced Oropharyngeal Cancer Patients Receiving Deintensified Therapy: Results from NRG-HN002
      Rathan M. Subramaniam, Lyudmila DeMora, Min Yao, Sue S. Yom, Maura Gillison, Jimmy J. Caudell, John Waldron, Ping Xia, Christine H. Chung, Minh Tam Truong, Michelle Echevarria, Jason W. Chan, Jessica L. Geiger, Loren Mell, Samantha Seaward, Wade L. Thorstad, Jonathan Jay Beitler, Khalil Sultanem, Diagjin Blakaj and Quynh-Thu Le
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 362-367; DOI: https://doi.org/10.2967/jnumed.122.264424
    • BRIEF COMMUNICATION

      • Novel <sup>68</sup>Ga-FAPI PET/CT Offers Oncologic Staging Without COVID-19 Vaccine–Related Pitfalls
        Open Access
        Novel 68Ga-FAPI PET/CT Offers Oncologic Staging Without COVID-19 Vaccine–Related Pitfalls
        Tristan T. Demmert, Ines Maric, Kelsey L. Pomykala, Katharina Lueckerath, Jens Siveke, Benedikt M. Schaarschmidt, Rainer Hamacher, Ken Herrmann and Wolfgang P. Fendler
        Journal of Nuclear Medicine March 1, 2023, 64 (3) 368-371; DOI: https://doi.org/10.2967/jnumed.122.264872

Theranostics

  • Clinical

    • PSMA-Directed Imaging and Therapy of Salivary Gland Tumors: A Single-Center Retrospective Study
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      PSMA-Directed Imaging and Therapy of Salivary Gland Tumors: A Single-Center Retrospective Study
      Caner Civan, Stefan Kasper, Christoph Berliner, Pedro Fragoso-Costa, Viktor Grünwald, Michael Pogorzelski, Benedikt Michael Schaarschmidt, Stephan Lang, David Kersting, Michael Nader, Katharina Lückerath, Ken Herrmann, Wolfgang P. Fendler and Manuel Weber
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 372-378; DOI: https://doi.org/10.2967/jnumed.122.264342
    • Comparison of <sup>68</sup>Ga-PSMA-617 PET/CT and <sup>68</sup>Ga-RM2 PET/CT in Patients with Localized Prostate Cancer Who Are Candidates for Radical Prostatectomy: A Prospective, Single-Arm, Single-Center, Phase II Study
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      Comparison of 68Ga-PSMA-617 PET/CT and 68Ga-RM2 PET/CT in Patients with Localized Prostate Cancer Who Are Candidates for Radical Prostatectomy: A Prospective, Single-Arm, Single-Center, Phase II Study
      Romain Schollhammer, Grégoire Robert, Julien Asselineau, Mokrane Yacoub, Delphine Vimont, Nicolas Balamoutoff, Franck Bladou, Antoine Bénard, Elif Hindié, Henri de Clermont Gallerande and Clément Morgat
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 379-385; DOI: https://doi.org/10.2967/jnumed.122.263889
    • FEATURED ARTICLE OF THE MONTH

      • PET Imaging of Fibroblast Activation Protein in Various Types of Cancer Using <sup>68</sup>Ga-FAP-2286: Comparison with <sup>18</sup>F-FDG and <sup>68</sup>Ga-FAPI-46 in a Single-Center, Prospective Study
        You have access
        PET Imaging of Fibroblast Activation Protein in Various Types of Cancer Using 68Ga-FAP-2286: Comparison with 18F-FDG and 68Ga-FAPI-46 in a Single-Center, Prospective Study
        Yizhen Pang, Liang Zhao, Tinghua Meng, Weizhi Xu, Qin Lin, Hua Wu, Jingjing Zhang, Xiaoyuan Chen, Long Sun and Haojun Chen
        Journal of Nuclear Medicine March 1, 2023, 64 (3) 386-394; DOI: https://doi.org/10.2967/jnumed.122.264544
    • Predicting Outcomes of Indeterminate Bone Lesions on <sup>18</sup>F-DCFPyL PSMA PET/CT Scans in the Setting of High-Risk Primary or Recurrent Prostate Cancer
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      Predicting Outcomes of Indeterminate Bone Lesions on 18F-DCFPyL PSMA PET/CT Scans in the Setting of High-Risk Primary or Recurrent Prostate Cancer
      Tim E. Phelps, Stephanie A. Harmon, Esther Mena, Liza Lindenberg, Joanna H. Shih, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke and Baris Turkbey
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 395-401; DOI: https://doi.org/10.2967/jnumed.122.264334
    • <sup>177</sup>Lu-PSMA-I&amp;T for Treatment of Metastatic Castration-Resistant Prostate Cancer: Prognostic Value of Scintigraphic and Clinical Biomarkers
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      177Lu-PSMA-I&T for Treatment of Metastatic Castration-Resistant Prostate Cancer: Prognostic Value of Scintigraphic and Clinical Biomarkers
      Amir Karimzadeh, Matthias Heck, Robert Tauber, Karina Knorr, Bernhard Haller, Calogero D’Alessandria, Wolfgang A. Weber, Matthias Eiber and Isabel Rauscher
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 402-409; DOI: https://doi.org/10.2967/jnumed.122.264402
    • <sup>177</sup>Lu-PSMA SPECT Quantitation at 6 Weeks (Dose 2) Predicts Short Progression-Free Survival for Patients Undergoing <sup>177</sup>Lu-PSMA-I&amp;T Therapy
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      177Lu-PSMA SPECT Quantitation at 6 Weeks (Dose 2) Predicts Short Progression-Free Survival for Patients Undergoing 177Lu-PSMA-I&T Therapy
      Nikeith John, Sarennya Pathmanandavel, Megan Crumbaker, William Counter, Bao Ho, Andrew O. Yam, Peter Wilson, Remy Niman, Maria Ayers, Aron Poole, Adam Hickey, Shikha Agrawal, Gary Perkins, Annukka Kallinen, Enid Eslick, Martin R. Stockler, Anthony M. Joshua, Andrew Nguyen and Louise Emmett
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 410-415; DOI: https://doi.org/10.2967/jnumed.122.264677

Cardiovascular

  • Clinical

    • Exploring Vessel Wall Biology In Vivo by Ultrasensitive Total-Body PET
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      Exploring Vessel Wall Biology In Vivo by Ultrasensitive Total-Body PET
      Thorsten Derlin, Benjamin A. Spencer, Martin Mamach, Yasser Abdelhafez, Lorenzo Nardo, Ramsey D. Badawi, Simon R. Cherry and Frank M. Bengel
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 416-422; DOI: https://doi.org/10.2967/jnumed.122.264550

Pulmonary

  • Clinical

    • PET Imaging of Neutrophil Elastase with <sup>11</sup>C-GW457427 in Acute Respiratory Distress Syndrome in Pigs
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      PET Imaging of Neutrophil Elastase with 11C-GW457427 in Acute Respiratory Distress Syndrome in Pigs
      Emmi Puuvuori, Elena Chiodaroli, Sergio Estrada, Pierre Cheung, Norbert Lubenow, Jonathan Sigfridsson, Hampus Romelin, Sofie Ingvast, Mathias Elgland, Francesco Liggieri, Olle Korsgren, Gaetano Perchiazzi, Olof Eriksson and Gunnar Antoni
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 423-429; DOI: https://doi.org/10.2967/jnumed.122.264306

Neurology

  • Clinical

    • <sup>68</sup>Ga-DOTA PET for Diagnosis of Spinal Cerebrospinal Fluid Leaks
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      68Ga-DOTA PET for Diagnosis of Spinal Cerebrospinal Fluid Leaks
      Petros Evangelou, Mohamed Aymen Omrane, Johannes Thurow, Michael Mix, Christian Fung, Niklas Lützen, Ganna Blazhenets, Horst Urbach, Jürgen Beck and Philipp T. Meyer
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 430-436; DOI: https://doi.org/10.2967/jnumed.122.264059
    • A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer’s Disease Continuum
      Open Access
      A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer’s Disease Continuum
      Emma M. Coomans, Inge M.W. Verberk, Rik Ossenkoppele, Sander C.J. Verfaillie, Denise Visser, Mariam Gouda, Hayel Tuncel, Emma E. Wolters, Tessa Timmers, Albert D. Windhorst, Sandeep S.V. Golla, Philip Scheltens, Wiesje M. van, der Flier, Bart N.M. van Berckel and Charlotte E. Teunissen
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 437-443; DOI: https://doi.org/10.2967/jnumed.122.264279
    • A Visual Interpretation Algorithm for Assessing Brain Tauopathy with <sup>18</sup>F-MK-6240 PET
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      A Visual Interpretation Algorithm for Assessing Brain Tauopathy with 18F-MK-6240 PET
      John P. Seibyl, Jonathan M. DuBois, Annie Racine, Jessica Collins, Qi Guo, Dustin Wooten, Eddie Stage, David Cheng, Roger N. Gunn, Lilly Porat, Alex Whittington, Phillip H. Kuo, Masanori Ichise, Robert Comley, Laurent Martarello and Cristian Salinas
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 444-451; DOI: https://doi.org/10.2967/jnumed.122.264371
    • Open Access
      The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of [18F]MK6240 Tau PET in Target Regions
      Cécile Tissot, Stijn Servaes, Firoza Z. Lussier, João Pedro Ferrari-Souza, Joseph Therriault, Pâmela C.L. Ferreira, Gleb Bezgin, Bruna Bellaver, Douglas Teixeira Leffa, Sulantha S. Mathotaarachchi, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita-Poltronetti, Yi-Ting Wang, Jaime Fernandez-Arias, Andrea L. Benedet, Eduardo R. Zimmer, Jean-Paul Soucy, Dana L. Tudorascu, Annie D. Cohen, Madeleine Sharp, Serge Gauthier, Gassan Massarweh, Brian Lopresti, William E. Klunk, Suzanne L. Baker, Victor L. Villemagne, Pedro Rosa-Neto and Tharick A. Pascoal
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 452-459; DOI: https://doi.org/10.2967/jnumed.122.264434
    • Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy
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      Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy
      Cassis Varlow and Neil Vasdev
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 460-465; DOI: https://doi.org/10.2967/jnumed.122.264404
  • Basic

    • Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of 3,4-Methylenedioxymethamphetamine
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      Neurovascular Uncoupling: Multimodal Imaging Delineates the Acute Effects of 3,4-Methylenedioxymethamphetamine
      Tudor M. Ionescu, Mario Amend, Tadashi Watabe, Jun Hatazawa, Andreas Maurer, Gerald Reischl, Bernd J. Pichler, Hans F. Wehrl and Kristina Herfert
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 466-471; DOI: https://doi.org/10.2967/jnumed.122.264391

AI/Advanced Image Analysis

  • Translational

    • Deep Learning–Based Attenuation Correction Improves Diagnostic Accuracy of Cardiac SPECT
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      Deep Learning–Based Attenuation Correction Improves Diagnostic Accuracy of Cardiac SPECT
      Aakash D. Shanbhag, Robert J.H. Miller, Konrad Pieszko, Mark Lemley, Paul Kavanagh, Attila Feher, Edward J. Miller, Albert J. Sinusas, Philipp A. Kaufmann, Donghee Han, Cathleen Huang, Joanna X. Liang, Daniel S. Berman, Damini Dey and Piotr J. Slomka
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 472-478; DOI: https://doi.org/10.2967/jnumed.122.264429

Physics And Instrumentation

  • Basic

    • FEATURED BASIC SCIENCE ARTICLE

      • Development of a Lensless Radiomicroscope for Cellular-Resolution Radionuclide Imaging
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        Development of a Lensless Radiomicroscope for Cellular-Resolution Radionuclide Imaging
        Justin S. Klein, Tae Jin Kim and Guillem Pratx
        Journal of Nuclear Medicine March 1, 2023, 64 (3) 479-484; DOI: https://doi.org/10.2967/jnumed.122.264021

Radiopharmaceuticals

  • Clinical

    • Adverse Clinical Events at the Injection Site Are Exceedingly Rare After Reported Radiopharmaceutical Extravasation in Patients Undergoing <sup>99m</sup>Tc-MDP Whole-Body Bone Scintigraphy: A 12-Year Experience
      Open Access
      Adverse Clinical Events at the Injection Site Are Exceedingly Rare After Reported Radiopharmaceutical Extravasation in Patients Undergoing 99mTc-MDP Whole-Body Bone Scintigraphy: A 12-Year Experience
      Ashwin Singh Parihar, Lisa R. Schmidt, John Crandall, Farrokh Dehdashti and Richard L. Wahl
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 485-490; DOI: https://doi.org/10.2967/jnumed.122.264994
    • INVITED PERSPECTIVE

      • You have access
        Extravasation of Diagnostic Radiopharmaceuticals: A Wolf in Sheep’s Clothing?
        Jochem A.J. van der Pol and Felix M. Mottaghy
        Journal of Nuclear Medicine March 1, 2023, 64 (3) 491-492; DOI: https://doi.org/10.2967/jnumed.122.265038

Radiobiology/Dosimetry

  • Basic

    • A Realistic Multiregion Mouse Kidney Dosimetry Model to Support the Preclinical Evaluation of Potential Nephrotoxicity of Radiopharmaceutical Therapy
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      A Realistic Multiregion Mouse Kidney Dosimetry Model to Support the Preclinical Evaluation of Potential Nephrotoxicity of Radiopharmaceutical Therapy
      Clarita Saldarriaga Vargas, Lara Struelens, Matthias D’Huyvetter, Vicky Caveliers and Peter Covens
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 493-499; DOI: https://doi.org/10.2967/jnumed.122.264453

Illustrated Post

  • Clinical

    • You have access
      Progression or Response: New Liver Lesions in a Patient with Responding Hodgkin Lymphoma
      Ashwin Singh Parihar, Adeel Haq, Richard L. Wahl and Amin H. Jahromi
      Journal of Nuclear Medicine March 1, 2023, 64 (3) 500; DOI: https://doi.org/10.2967/jnumed.122.264995

Letters to the Editor

  • Open Access
    Theranostic Digital Twins: An Indispensable Prerequisite for Personalized Cancer Care
    Julia Brosch-Lenz, Carlos Uribe, Arman Rahmim and Babak Saboury
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 501; DOI: https://doi.org/10.2967/jnumed.122.264929

Departments

  • You have access
    This Month in JNM
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 8A;
  • You have access
    Erratum
    Journal of Nuclear Medicine March 1, 2023, 64 (3) 490;
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In this issue

Journal of Nuclear Medicine: 64 (3)
Journal of Nuclear Medicine
Vol. 64, Issue 3
March 1, 2023
  • Table of Contents
  • Table of Contents (PDF)
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  • Index by author
  • Complete Issue (PDF)

Issue highlights

  • PET Imaging of Fibroblast Activation Protein in Various Types of Cancer Using 68Ga-FAP-2286: Comparison with 18F-FDG and 68Ga-FAPI-46 in a Single-Center, Prospective Study
  • Development of a Lensless Radiomicroscope for Cellular-Resolution Radionuclide Imaging
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  • First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
  • Performance Evaluation of the uEXPLORER Total-Body PET/CT Scanner Based on NEMA NU 2-2018 with Additional Tests to Characterize PET Scanners with a Long Axial Field of View
  • Slow but Evident Recovery from Neocortical Dysfunction and Cognitive Impairment in a Series of Chronic COVID-19 Patients
  • Tumor Response to Radiopharmaceutical Therapies: The Knowns and the Unknowns
  • Is FDG maximum standardized uptake value (SUV max) of primary breast cancer can predict axillary lymph node metastasis?
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