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Journal of Nuclear Medicine

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Research ArticleClinical Investigation

Static and Dynamic 68Ga-FAPI PET/CT for the Detection of Malignant Transformation of Intraductal Papillary Mucinous Neoplasia of the Pancreas

Matthias Lang, Anna-Maria Spektor, Thomas Hielscher, Jorge Hoppner, Frederik M. Glatting, Felix Bicu, Thilo Hackert, Ulrike Heger, Thomas Pausch, Ewgenija Gutjahr, Hendrik Rathke, Frederik L. Giesel, Clemens Kratochwil, Christine Tjaden, Uwe Haberkorn and Manuel Röhrich
Journal of Nuclear Medicine February 2023, 64 (2) 244-251; DOI: https://doi.org/10.2967/jnumed.122.264361
Matthias Lang
1Department of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany;
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Anna-Maria Spektor
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
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Thomas Hielscher
3Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany;
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Jorge Hoppner
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
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Frederik M. Glatting
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
4Clinical Cooperation Unit Molecular and Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;
5Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany;
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Felix Bicu
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
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Thilo Hackert
1Department of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany;
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Ulrike Heger
1Department of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany;
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Thomas Pausch
1Department of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany;
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Ewgenija Gutjahr
6Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany;
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Hendrik Rathke
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
7Department of Nuclear Medicine, The Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;
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Frederik L. Giesel
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
8Department of Nuclear Medicine, University Hospital Düsseldorf, Düsseldorf, Germany;
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Clemens Kratochwil
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
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Christine Tjaden
1Department of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany;
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Uwe Haberkorn
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
9Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research DZL, Heidelberg, Germany; and
10Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Manuel Röhrich
2Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany;
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Journal of Nuclear Medicine: 64 (2)
Journal of Nuclear Medicine
Vol. 64, Issue 2
February 1, 2023
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Static and Dynamic 68Ga-FAPI PET/CT for the Detection of Malignant Transformation of Intraductal Papillary Mucinous Neoplasia of the Pancreas
Matthias Lang, Anna-Maria Spektor, Thomas Hielscher, Jorge Hoppner, Frederik M. Glatting, Felix Bicu, Thilo Hackert, Ulrike Heger, Thomas Pausch, Ewgenija Gutjahr, Hendrik Rathke, Frederik L. Giesel, Clemens Kratochwil, Christine Tjaden, Uwe Haberkorn, Manuel Röhrich
Journal of Nuclear Medicine Feb 2023, 64 (2) 244-251; DOI: 10.2967/jnumed.122.264361

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Static and Dynamic 68Ga-FAPI PET/CT for the Detection of Malignant Transformation of Intraductal Papillary Mucinous Neoplasia of the Pancreas
Matthias Lang, Anna-Maria Spektor, Thomas Hielscher, Jorge Hoppner, Frederik M. Glatting, Felix Bicu, Thilo Hackert, Ulrike Heger, Thomas Pausch, Ewgenija Gutjahr, Hendrik Rathke, Frederik L. Giesel, Clemens Kratochwil, Christine Tjaden, Uwe Haberkorn, Manuel Röhrich
Journal of Nuclear Medicine Feb 2023, 64 (2) 244-251; DOI: 10.2967/jnumed.122.264361
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Cited By...

  • Diagnostic Potential of Supplemental Static and Dynamic 68Ga-FAPI-46 PET for Primary 18F-FDG-Negative Pulmonary Lesions
  • Immunohistochemical FAP Expression Reflects 68Ga-FAPI PET Imaging Properties of Low- and High-Grade Intraductal Papillary Mucinous Neoplasms and Pancreatic Ductal Adenocarcinoma
  • Tumor Characterization by [68Ga]FAPI-46 PET/CT Can Improve Treatment Selection for Pancreatic Cancer Patients: An Interim Analysis of a Prospective Clinical Trial
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More in this TOC Section

  • First-in-Human Study of 18F-Labeled PET Tracer for Glutamate AMPA Receptor [18F]K-40: A Derivative of [11C]K-2
  • Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis
  • [11C]Carfentanil PET Whole-Body Imaging of μ-Opioid Receptors: A First in-Human Study
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Keywords

  • fibroblast activation protein
  • FAPI
  • PET
  • dynamic PET
  • cancer
  • PDAC
  • IPMN
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